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2. A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis. Doebele RC; Schulze-Hoepfner FT; Hong J; Chlenski A; Zeitlin BD; Goel K; Gomes S; Liu Y; Abe MK; Nor JE; Lingen MW; Rosner MR Blood; 2009 Nov; 114(20):4592-600. PubMed ID: 19710505 [TBL] [Abstract][Full Text] [Related]
3. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. de Rooij J; Zwartkruis FJ; Verheijen MH; Cool RH; Nijman SM; Wittinghofer A; Bos JL Nature; 1998 Dec; 396(6710):474-7. PubMed ID: 9853756 [TBL] [Abstract][Full Text] [Related]
4. Cyclic AMP signaling as a mediator of vasculogenic mimicry in aggressive human melanoma cells in vitro. Lissitzky JC; Parriaux D; Ristorcelli E; Vérine A; Lombardo D; Verrando P Cancer Res; 2009 Feb; 69(3):802-9. PubMed ID: 19176384 [TBL] [Abstract][Full Text] [Related]
5. Cilostazol Induces PGI2 Production via Activation of the Downstream Epac-1/Rap1 Signaling Cascade to Increase Intracellular Calcium by PLCε and to Activate p44/42 MAPK in Human Aortic Endothelial Cells. Hashimoto A; Tanaka M; Takeda S; Ito H; Nagano K PLoS One; 2015; 10(7):e0132835. PubMed ID: 26181635 [TBL] [Abstract][Full Text] [Related]
6. Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor. Rangarajan S; Enserink JM; Kuiperij HB; de Rooij J; Price LS; Schwede F; Bos JL J Cell Biol; 2003 Feb; 160(4):487-93. PubMed ID: 12578910 [TBL] [Abstract][Full Text] [Related]
7. cAMP/EPAC Signaling Enables ETV2 to Induce Endothelial Cells with High Angiogenesis Potential. Kim JJ; Kim DH; Lee JY; Lee BC; Kang I; Kook MG; Kong D; Choi SW; Woo HM; Kim DI; Kang KS Mol Ther; 2020 Feb; 28(2):466-478. PubMed ID: 31864907 [TBL] [Abstract][Full Text] [Related]
8. Regulation of decidualization in human endometrial stromal cells through exchange protein directly activated by cyclic AMP (Epac). Kusama K; Yoshie M; Tamura K; Kodaka Y; Hirata A; Sakurai T; Bai H; Imakawa K; Nishi H; Isaka K; Nagai T; Nagao T; Tachikawa E Placenta; 2013 Mar; 34(3):212-21. PubMed ID: 23352189 [TBL] [Abstract][Full Text] [Related]
9. EPAC activation inhibits acetaldehyde-induced activation and proliferation of hepatic stellate cell via Rap1. Yang Y; Yang F; Wu X; Lv X; Li J Can J Physiol Pharmacol; 2016 May; 94(5):498-507. PubMed ID: 26854595 [TBL] [Abstract][Full Text] [Related]
10. EPAC-RAP1 Axis-Mediated Switch in the Response of Primary and Metastatic Melanoma to Cyclic AMP. Rodríguez CI; Castro-Pérez E; Prabhakar K; Block L; Longley BJ; Wisinski JA; Kimple ME; Setaluri V Mol Cancer Res; 2017 Dec; 15(12):1792-1802. PubMed ID: 28851815 [TBL] [Abstract][Full Text] [Related]
11. The RAP1 guanine nucleotide exchange factor Epac2 couples cyclic AMP and Ras signals at the plasma membrane. Li Y; Asuri S; Rebhun JF; Castro AF; Paranavitana NC; Quilliam LA J Biol Chem; 2006 Feb; 281(5):2506-14. PubMed ID: 16316996 [TBL] [Abstract][Full Text] [Related]
12. Cyclic adenosine 5'-monophosphate-stimulated neurotensin secretion is mediated through Rap1 downstream of both Epac and protein kinase A signaling pathways. Li J; O'Connor KL; Cheng X; Mei FC; Uchida T; Townsend CM; Evers BM Mol Endocrinol; 2007 Jan; 21(1):159-71. PubMed ID: 17068197 [TBL] [Abstract][Full Text] [Related]
13. Exchange protein activated by cyclic AMP (Epac)-mediated induction of suppressor of cytokine signaling 3 (SOCS-3) in vascular endothelial cells. Sands WA; Woolson HD; Milne GR; Rutherford C; Palmer TM Mol Cell Biol; 2006 Sep; 26(17):6333-46. PubMed ID: 16914720 [TBL] [Abstract][Full Text] [Related]
14. cAMP-Epac2-mediated activation of Rap1 in developing male germ cells: RA-RhoGAP as a possible direct down-stream effector. Aivatiadou E; Ripolone M; Brunetti F; Berruti G Mol Reprod Dev; 2009 Apr; 76(4):407-16. PubMed ID: 18937323 [TBL] [Abstract][Full Text] [Related]
15. Insights into exchange factor directly activated by cAMP (EPAC) as potential target for cancer treatment. Kumar N; Prasad P; Jash E; Saini M; Husain A; Goldman A; Sehrawat S Mol Cell Biochem; 2018 Oct; 447(1-2):77-92. PubMed ID: 29417338 [TBL] [Abstract][Full Text] [Related]
16. Epac1-Rap1 signaling regulates monocyte adhesion and chemotaxis. Lorenowicz MJ; van Gils J; de Boer M; Hordijk PL; Fernandez-Borja M J Leukoc Biol; 2006 Dec; 80(6):1542-52. PubMed ID: 16940330 [TBL] [Abstract][Full Text] [Related]
17. Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis. Branham MT; Bustos MA; De Blas GA; Rehmann H; Zarelli VE; Treviño CL; Darszon A; Mayorga LS; Tomes CN J Biol Chem; 2009 Sep; 284(37):24825-39. PubMed ID: 19546222 [TBL] [Abstract][Full Text] [Related]
18. Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway. Fukuhara S; Sakurai A; Sano H; Yamagishi A; Somekawa S; Takakura N; Saito Y; Kangawa K; Mochizuki N Mol Cell Biol; 2005 Jan; 25(1):136-46. PubMed ID: 15601837 [TBL] [Abstract][Full Text] [Related]
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20. Protein Kinase A-independent Ras Protein Activation Cooperates with Rap1 Protein to Mediate Activation of the Extracellular Signal-regulated Kinases (ERK) by cAMP. Li Y; Dillon TJ; Takahashi M; Earley KT; Stork PJ J Biol Chem; 2016 Oct; 291(41):21584-21595. PubMed ID: 27531745 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]