BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

189 related articles for article (PubMed ID: 17498648)

  • 1. Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila.
    Lee SB; Kim W; Lee S; Chung J
    Biochem Biophys Res Commun; 2007 Jun; 358(2):534-9. PubMed ID: 17498648
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Knockdown transgenic Lrrk Drosophila resists paraquat-induced locomotor impairment and neurodegeneration: A therapeutic strategy for Parkinson's disease.
    Quintero-Espinosa D; Jimenez-Del-Rio M; Velez-Pardo C
    Brain Res; 2017 Feb; 1657():253-261. PubMed ID: 28041945
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The Drosophila hep pathway mediates Lrrk2-induced neurodegeneration.
    Yang D; Thomas JM; Li T; Lee Y; Liu Z; Smith WW
    Biochem Cell Biol; 2018 Aug; 96(4):441-449. PubMed ID: 29268033
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Genetic dissection reveals that Akt is the critical kinase downstream of LRRK2 to phosphorylate and inhibit FOXO1, and promotes neuron survival.
    Chuang CL; Lu YN; Wang HC; Chang HY
    Hum Mol Genet; 2014 Nov; 23(21):5649-58. PubMed ID: 24916379
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The role of tyrosine hydroxylase-dopamine pathway in Parkinson's disease pathogenesis.
    Zhou ZD; Saw WT; Ho PGH; Zhang ZW; Zeng L; Chang YY; Sun AXY; Ma DR; Wang HY; Zhou L; Lim KL; Tan EK
    Cell Mol Life Sci; 2022 Nov; 79(12):599. PubMed ID: 36409355
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Vps35 in cooperation with LRRK2 regulates synaptic vesicle endocytosis through the endosomal pathway in Drosophila.
    Inoshita T; Arano T; Hosaka Y; Meng H; Umezaki Y; Kosugi S; Morimoto T; Koike M; Chang HY; Imai Y; Hattori N
    Hum Mol Genet; 2017 Aug; 26(15):2933-2948. PubMed ID: 28482024
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Novel ethyl methanesulfonate (EMS)-induced null alleles of the Drosophila homolog of LRRK2 reveal a crucial role in endolysosomal functions and autophagy in vivo.
    Dodson MW; Leung LK; Lone M; Lizzio MA; Guo M
    Dis Model Mech; 2014 Dec; 7(12):1351-63. PubMed ID: 25288684
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Effects of sevoflurane on leucine-rich repeat kinase 2-associated Drosophila model of Parkinson's disease.
    Shan Z; Cai S; Zhang T; Kuang L; Wang Q; Xiu H; Wen J; Gu H; Xu K
    Mol Med Rep; 2015 Mar; 11(3):2062-70. PubMed ID: 25406035
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Thiol peroxidases ameliorate LRRK2 mutant-induced mitochondrial and dopaminergic neuronal degeneration in Drosophila.
    Angeles DC; Ho P; Chua LL; Wang C; Yap YW; Ng C; Zhou Zd; Lim KL; Wszolek ZK; Wang HY; Tan EK
    Hum Mol Genet; 2014 Jun; 23(12):3157-65. PubMed ID: 24459295
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning.
    Dodson MW; Zhang T; Jiang C; Chen S; Guo M
    Hum Mol Genet; 2012 Mar; 21(6):1350-63. PubMed ID: 22171073
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila.
    Imai Y; Gehrke S; Wang HQ; Takahashi R; Hasegawa K; Oota E; Lu B
    EMBO J; 2008 Sep; 27(18):2432-43. PubMed ID: 18701920
    [TBL] [Abstract][Full Text] [Related]  

  • 12. LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis.
    Matta S; Van Kolen K; da Cunha R; van den Bogaart G; Mandemakers W; Miskiewicz K; De Bock PJ; Morais VA; Vilain S; Haddad D; Delbroek L; Swerts J; Chávez-Gutiérrez L; Esposito G; Daneels G; Karran E; Holt M; Gevaert K; Moechars DW; De Strooper B; Verstreken P
    Neuron; 2012 Sep; 75(6):1008-21. PubMed ID: 22998870
    [TBL] [Abstract][Full Text] [Related]  

  • 13. LRRK2 kinase activity mediates toxic interactions between genetic mutation and oxidative stress in a Drosophila model: suppression by curcumin.
    Yang D; Li T; Liu Z; Arbez N; Yan J; Moran TH; Ross CA; Smith WW
    Neurobiol Dis; 2012 Sep; 47(3):385-92. PubMed ID: 22668778
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Activation of FoxO by LRRK2 induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila.
    Kanao T; Venderova K; Park DS; Unterman T; Lu B; Imai Y
    Hum Mol Genet; 2010 Oct; 19(19):3747-58. PubMed ID: 20624856
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration.
    Tsika E; Kannan M; Foo CS; Dikeman D; Glauser L; Gellhaar S; Galter D; Knott GW; Dawson TM; Dawson VL; Moore DJ
    Neurobiol Dis; 2014 Nov; 71():345-58. PubMed ID: 25174890
    [TBL] [Abstract][Full Text] [Related]  

  • 16. LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction.
    Lee S; Liu HP; Lin WY; Guo H; Lu B
    J Neurosci; 2010 Dec; 30(50):16959-69. PubMed ID: 21159966
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Motor Impairments and Dopaminergic Defects Caused by Loss of Leucine-Rich Repeat Kinase Function in Mice.
    Huang G; Bloodgood DW; Kang J; Shahapal A; Chen P; Kaganovsky K; Kim JI; Ding JB; Shen J
    J Neurosci; 2022 Jun; 42(23):4755-4765. PubMed ID: 35534227
    [TBL] [Abstract][Full Text] [Related]  

  • 18. LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson's disease.
    Yao C; El Khoury R; Wang W; Byrd TA; Pehek EA; Thacker C; Zhu X; Smith MA; Wilson-Delfosse AL; Chen SG
    Neurobiol Dis; 2010 Oct; 40(1):73-81. PubMed ID: 20382224
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A Drosophila model for LRRK2-linked parkinsonism.
    Liu Z; Wang X; Yu Y; Li X; Wang T; Jiang H; Ren Q; Jiao Y; Sawa A; Moran T; Ross CA; Montell C; Smith WW
    Proc Natl Acad Sci U S A; 2008 Feb; 105(7):2693-8. PubMed ID: 18258746
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The synaptic function of LRRK2.
    Lee S; Imai Y; Gehrke S; Liu S; Lu B
    Biochem Soc Trans; 2012 Oct; 40(5):1047-51. PubMed ID: 22988863
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.