These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

191 related articles for article (PubMed ID: 17505108)

  • 1. Structure-assisted discovery of Variola major H1 phosphatase inhibitors.
    Phan J; Tropea JE; Waugh DS
    Acta Crystallogr D Biol Crystallogr; 2007 Jun; 63(Pt 6):698-704. PubMed ID: 17505108
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structural basis for specificity in the poxvirus topoisomerase.
    Perry K; Hwang Y; Bushman FD; Van Duyne GD
    Mol Cell; 2006 Aug; 23(3):343-54. PubMed ID: 16885024
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The structural basis for the selectivity of benzotriazole inhibitors of PTP1B.
    Scapin G; Patel SB; Becker JW; Wang Q; Desponts C; Waddleton D; Skorey K; Cromlish W; Bayly C; Therien M; Gauthier JY; Li CS; Lau CK; Ramachandran C; Kennedy BP; Asante-Appiah E
    Biochemistry; 2003 Oct; 42(39):11451-9. PubMed ID: 14516196
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Overproduction, purification, and biochemical characterization of the dual specificity H1 protein phosphatase encoded by variola major virus.
    Tropea JE; Phan J; Waugh DS
    Protein Expr Purif; 2006 Nov; 50(1):31-6. PubMed ID: 16793284
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor.
    Liu G; Xin Z; Pei Z; Hajduk PJ; Abad-Zapatero C; Hutchins CW; Zhao H; Lubben TH; Ballaron SJ; Haasch DL; Kaszubska W; Rondinone CM; Trevillyan JM; Jirousek MR
    J Med Chem; 2003 Sep; 46(20):4232-5. PubMed ID: 13678400
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery.
    Evdokimov AG; Pokross M; Walter R; Mekel M; Cox B; Li C; Bechard R; Genbauffe F; Andrews R; Diven C; Howard B; Rastogi V; Gray J; Maier M; Peters KG
    Acta Crystallogr D Biol Crystallogr; 2006 Dec; 62(Pt 12):1435-45. PubMed ID: 17139078
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structure-based optimization of benzoic acids as inhibitors of protein tyrosine phosphatase 1B and low molecular weight protein tyrosine phosphatase.
    Maccari R; Ottanà R; Ciurleo R; Paoli P; Manao G; Camici G; Laggner C; Langer T
    ChemMedChem; 2009 Jun; 4(6):957-62. PubMed ID: 19288492
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design of inhibitors of thymidylate kinase from Variola virus as new selective drugs against smallpox.
    Guimarães AP; de Souza FR; Oliveira AA; Gonçalves AS; de Alencastro RB; Ramalho TC; França TC
    Eur J Med Chem; 2015 Feb; 91():72-90. PubMed ID: 25458183
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structure-based design and discovery of protein tyrosine phosphatase inhibitors incorporating novel isothiazolidinone heterocyclic phosphotyrosine mimetics.
    Combs AP; Yue EW; Bower M; Ala PJ; Wayland B; Douty B; Takvorian A; Polam P; Wasserman Z; Zhu W; Crawley ML; Pruitt J; Sparks R; Glass B; Modi D; McLaughlin E; Bostrom L; Li M; Galya L; Blom K; Hillman M; Gonneville L; Reid BG; Wei M; Becker-Pasha M; Klabe R; Huber R; Li Y; Hollis G; Burn TC; Wynn R; Liu P; Metcalf B
    J Med Chem; 2005 Oct; 48(21):6544-8. PubMed ID: 16220970
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Inhibitors of protein tyrosine phosphatases: next-generation drugs?
    Bialy L; Waldmann H
    Angew Chem Int Ed Engl; 2005 Jun; 44(25):3814-39. PubMed ID: 15900534
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Unraveling the structure of the variola topoisomerase IB-DNA complex: a possible new twist on smallpox therapy.
    Osheroff N
    Mol Interv; 2006 Oct; 6(5):245-8. PubMed ID: 17035663
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Monocyclic thiophenes as protein tyrosine phosphatase 1B inhibitors: capturing interactions with Asp48.
    Wan ZK; Lee J; Xu W; Erbe DV; Joseph-McCarthy D; Follows BC; Zhang YL
    Bioorg Med Chem Lett; 2006 Sep; 16(18):4941-5. PubMed ID: 16806920
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery of novel Cdc25 phosphatase inhibitors with micromolar activity based on the structure-based virtual screening.
    Park H; Bahn YJ; Jung SK; Jeong DG; Lee SH; Seo I; Yoon TS; Kim SJ; Ryu SE
    J Med Chem; 2008 Sep; 51(18):5533-41. PubMed ID: 18714978
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors.
    Moretto AF; Kirincich SJ; Xu WX; Smith MJ; Wan ZK; Wilson DP; Follows BC; Binnun E; Joseph-McCarthy D; Foreman K; Erbe DV; Zhang YL; Tam SK; Tam SY; Lee J
    Bioorg Med Chem; 2006 Apr; 14(7):2162-77. PubMed ID: 16303309
    [TBL] [Abstract][Full Text] [Related]  

  • 15. High-resolution structure of the Yersinia pestis protein tyrosine phosphatase YopH in complex with a phosphotyrosyl mimetic-containing hexapeptide.
    Phan J; Lee K; Cherry S; Tropea JE; Burke TR; Waugh DS
    Biochemistry; 2003 Nov; 42(45):13113-21. PubMed ID: 14609321
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structure-based design of protein tyrosine phosphatase-1B inhibitors.
    Black E; Breed J; Breeze AL; Embrey K; Garcia R; Gero TW; Godfrey L; Kenny PW; Morley AD; Minshull CA; Pannifer AD; Read J; Rees A; Russell DJ; Toader D; Tucker J
    Bioorg Med Chem Lett; 2005 May; 15(10):2503-7. PubMed ID: 15863305
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Fragment-based lead discovery using X-ray crystallography.
    Hartshorn MJ; Murray CW; Cleasby A; Frederickson M; Tickle IJ; Jhoti H
    J Med Chem; 2005 Jan; 48(2):403-13. PubMed ID: 15658854
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site.
    Wilson DP; Wan ZK; Xu WX; Kirincich SJ; Follows BC; Joseph-McCarthy D; Foreman K; Moretto A; Wu J; Zhu M; Binnun E; Zhang YL; Tam M; Erbe DV; Tobin J; Xu X; Leung L; Shilling A; Tam SY; Mansour TS; Lee J
    J Med Chem; 2007 Sep; 50(19):4681-98. PubMed ID: 17705360
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Peptidomimetic therapeutic agents targeting the protease enzyme of the human immunodeficiency virus and hepatitis C virus.
    Tsantrizos YS
    Acc Chem Res; 2008 Oct; 41(10):1252-63. PubMed ID: 18681464
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structure-based virtual screening approach to the discovery of novel inhibitors of eyes absent 2 phosphatase with various metal chelating moieties.
    Park H; Jung SK; Yu KR; Kim JH; Kim YS; Ko JH; Park BC; Kim SJ
    Chem Biol Drug Des; 2011 Oct; 78(4):642-50. PubMed ID: 21777393
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.