BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

629 related articles for article (PubMed ID: 17510057)

  • 21. Intestinal cell kinase (ICK) promotes activation of mTOR complex 1 (mTORC1) through phosphorylation of Raptor Thr-908.
    Wu D; Chapman JR; Wang L; Harris TE; Shabanowitz J; Hunt DF; Fu Z
    J Biol Chem; 2012 Apr; 287(15):12510-9. PubMed ID: 22356909
    [TBL] [Abstract][Full Text] [Related]  

  • 22. PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling.
    Woo SY; Kim DH; Jun CB; Kim YM; Haar EV; Lee SI; Hegg JW; Bandhakavi S; Griffin TJ; Kim DH
    J Biol Chem; 2007 Aug; 282(35):25604-12. PubMed ID: 17599906
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth.
    Acosta-Jaquez HA; Keller JA; Foster KG; Ekim B; Soliman GA; Feener EP; Ballif BA; Fingar DC
    Mol Cell Biol; 2009 Aug; 29(15):4308-24. PubMed ID: 19487463
    [TBL] [Abstract][Full Text] [Related]  

  • 24. cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity.
    Xie J; Ponuwei GA; Moore CE; Willars GB; Tee AR; Herbert TP
    Cell Signal; 2011 Dec; 23(12):1927-35. PubMed ID: 21763421
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation.
    Foster KG; Acosta-Jaquez HA; Romeo Y; Ekim B; Soliman GA; Carriere A; Roux PP; Ballif BA; Fingar DC
    J Biol Chem; 2010 Jan; 285(1):80-94. PubMed ID: 19864431
    [TBL] [Abstract][Full Text] [Related]  

  • 26. The dynamic mechanism of 4E-BP1 recognition and phosphorylation by mTORC1.
    Böhm R; Imseng S; Jakob RP; Hall MN; Maier T; Hiller S
    Mol Cell; 2021 Jun; 81(11):2403-2416.e5. PubMed ID: 33852892
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Dual inhibition of phosphatidylinositol 3-kinase/Akt and mammalian target of rapamycin signaling in human nonsmall cell lung cancer cells by a dietary flavonoid fisetin.
    Khan N; Afaq F; Khusro FH; Mustafa Adhami V; Suh Y; Mukhtar H
    Int J Cancer; 2012 Apr; 130(7):1695-705. PubMed ID: 21618507
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Mechanistic target of rapamycin complex 1 (mTORC1)-mediated phosphorylation is governed by competition between substrates for interaction with raptor.
    Dennis MD; Kimball SR; Jefferson LS
    J Biol Chem; 2013 Jan; 288(1):10-9. PubMed ID: 23184952
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins.
    Wang X; Beugnet A; Murakami M; Yamanaka S; Proud CG
    Mol Cell Biol; 2005 Apr; 25(7):2558-72. PubMed ID: 15767663
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Curcumin disrupts the Mammalian target of rapamycin-raptor complex.
    Beevers CS; Chen L; Liu L; Luo Y; Webster NJ; Huang S
    Cancer Res; 2009 Feb; 69(3):1000-8. PubMed ID: 19176385
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Raptor, a binding partner of target of rapamycin.
    Yonezawa K; Tokunaga C; Oshiro N; Yoshino K
    Biochem Biophys Res Commun; 2004 Jan; 313(2):437-41. PubMed ID: 14684181
    [TBL] [Abstract][Full Text] [Related]  

  • 32. PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.
    Sancak Y; Thoreen CC; Peterson TR; Lindquist RA; Kang SA; Spooner E; Carr SA; Sabatini DM
    Mol Cell; 2007 Mar; 25(6):903-15. PubMed ID: 17386266
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Target of rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1.
    Beugnet A; Wang X; Proud CG
    J Biol Chem; 2003 Oct; 278(42):40717-22. PubMed ID: 12912989
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40.
    Vander Haar E; Lee SI; Bandhakavi S; Griffin TJ; Kim DH
    Nat Cell Biol; 2007 Mar; 9(3):316-23. PubMed ID: 17277771
    [TBL] [Abstract][Full Text] [Related]  

  • 35. A role for Raptor phosphorylation in the mechanical activation of mTOR signaling.
    Frey JW; Jacobs BL; Goodman CA; Hornberger TA
    Cell Signal; 2014 Feb; 26(2):313-22. PubMed ID: 24239769
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.
    Hara K; Maruki Y; Long X; Yoshino K; Oshiro N; Hidayat S; Tokunaga C; Avruch J; Yonezawa K
    Cell; 2002 Jul; 110(2):177-89. PubMed ID: 12150926
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Altered nutrient response of mTORC1 as a result of changes in REDD1 expression: effect of obesity vs. REDD1 deficiency.
    Williamson DL; Li Z; Tuder RM; Feinstein E; Kimball SR; Dungan CM
    J Appl Physiol (1985); 2014 Aug; 117(3):246-56. PubMed ID: 24876363
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
    Yang H; Jiang X; Li B; Yang HJ; Miller M; Yang A; Dhar A; Pavletich NP
    Nature; 2017 Dec; 552(7685):368-373. PubMed ID: 29236692
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation.
    Carrière A; Cargnello M; Julien LA; Gao H; Bonneil E; Thibault P; Roux PP
    Curr Biol; 2008 Sep; 18(17):1269-77. PubMed ID: 18722121
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin.
    Toschi A; Lee E; Xu L; Garcia A; Gadir N; Foster DA
    Mol Cell Biol; 2009 Mar; 29(6):1411-20. PubMed ID: 19114562
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 32.