231 related articles for article (PubMed ID: 17512197)
1. Synthesis and SAR of selective benzothiophene, benzofuran, and indole-based peroxisome proliferator-activated receptor delta agonists.
Filzen GF; Bratton L; Cheng XM; Erasga N; Geyer A; Lee C; Lu G; Pulaski J; Sorenson RJ; Unangst PC; Trivedi BK; Xu X
Bioorg Med Chem Lett; 2007 Jul; 17(13):3630-5. PubMed ID: 17512197
[TBL] [Abstract][Full Text] [Related]
2. Discovery of highly potent and selective benzyloxybenzyl-based peroxisome proliferator-activator receptor (PPAR) delta agonists.
Bratton LD; Filzen GF; Geyer A; Hoffman JK; Lu G; Pulaski J; Trivedi BK; Unangst PC; Xu X
Bioorg Med Chem Lett; 2007 Jul; 17(13):3624-9. PubMed ID: 17498950
[TBL] [Abstract][Full Text] [Related]
3. Design, synthesis, and evaluation of potent, structurally novel peroxisome proliferator-activated receptor (PPAR) delta-selective agonists.
Kasuga J; Nakagome I; Aoyama A; Sako K; Ishizawa M; Ogura M; Makishima M; Hirono S; Hashimoto Y; Miyachi H
Bioorg Med Chem; 2007 Aug; 15(15):5177-90. PubMed ID: 17532641
[TBL] [Abstract][Full Text] [Related]
4. Sulfonylthiadiazoles with an unusual binding mode as partial dual peroxisome proliferator-activated receptor (PPAR) γ/δ agonists with high potency and in vivo efficacy.
Keil S; Matter H; Schönafinger K; Glien M; Mathieu M; Marquette JP; Michot N; Haag-Diergarten S; Urmann M; Wendler W
ChemMedChem; 2011 Apr; 6(4):633-53. PubMed ID: 21400663
[TBL] [Abstract][Full Text] [Related]
5. Design, synthesis, and evaluation of a novel series of alpha-substituted phenylpropanoic acid derivatives as human peroxisome proliferator-activated receptor (PPAR) alpha/delta dual agonists for the treatment of metabolic syndrome.
Kasuga J; Yamasaki D; Araya Y; Nakagawa A; Makishima M; Doi T; Hashimoto Y; Miyachi H
Bioorg Med Chem; 2006 Dec; 14(24):8405-14. PubMed ID: 16996742
[TBL] [Abstract][Full Text] [Related]
6. Discovery and SAR of para-alkylthiophenoxyacetic acids as potent and selective PPARdelta agonists.
Zhang R; Deangelis A; Wang A; Sieber-McMaster E; Li X; Russell R; Pelton P; Xu J; Zhu P; Zhou L; Demarest K; Murray WV; Kuo GH
Bioorg Med Chem Lett; 2009 Feb; 19(4):1101-4. PubMed ID: 19168353
[TBL] [Abstract][Full Text] [Related]
7. Minor structural modifications convert a selective PPARalpha agonist into a potent, highly selective PPARdelta agonist.
Weigand S; Bischoff H; Dittrich-Wengenroth E; Heckroth H; Lang D; Vaupel A; Woltering M
Bioorg Med Chem Lett; 2005 Oct; 15(20):4619-23. PubMed ID: 16115765
[TBL] [Abstract][Full Text] [Related]
8. Design and synthesis of alkoxyindolyl-3-acetic acid analogs as peroxisome proliferator-activated receptor-γ/δ agonists.
Gim HJ; Li H; Lee E; Ryu JH; Jeon R
Bioorg Med Chem Lett; 2013 Jan; 23(2):513-7. PubMed ID: 23265886
[TBL] [Abstract][Full Text] [Related]
9. Novel bisaryl substituted thiazoles and oxazoles as highly potent and selective peroxisome proliferator-activated receptor delta agonists.
Epple R; Cow C; Xie Y; Azimioara M; Russo R; Wang X; Wityak J; Karanewsky DS; Tuntland T; Nguyêñ-Trân VT; Cuc Ngo C; Huang D; Saez E; Spalding T; Gerken A; Iskandar M; Seidel HM; Tian SS
J Med Chem; 2010 Jan; 53(1):77-105. PubMed ID: 19928766
[TBL] [Abstract][Full Text] [Related]
10. Synthesis and identification of [1,2,4]thiadiazole derivatives as a new series of potent and orally active dual agonists of peroxisome proliferator-activated receptors alpha and delta.
Shen L; Zhang Y; Wang A; Sieber-McMaster E; Chen X; Pelton P; Xu JZ; Yang M; Zhu P; Zhou L; Reuman M; Hu Z; Russell R; Gibbs AC; Ross H; Demarest K; Murray WV; Kuo GH
J Med Chem; 2007 Aug; 50(16):3954-63. PubMed ID: 17608467
[TBL] [Abstract][Full Text] [Related]
11. Synthesis and structure-activity relationships of thiadiazole-derivatives as potent and orally active peroxisome proliferator-activated receptors alpha/delta dual agonists.
Shen L; Zhang Y; Wang A; Sieber-McMaster E; Chen X; Pelton P; Xu JZ; Yang M; Zhu P; Zhou L; Reuman M; Hu Z; Russell R; Gibbs AC; Ross H; Demarest K; Murray WV; Kuo GH
Bioorg Med Chem; 2008 Mar; 16(6):3321-41. PubMed ID: 18155554
[TBL] [Abstract][Full Text] [Related]
12. Design and synthesis of novel and potent amide linked PPARgamma/delta dual agonists.
Shi Q; Canada EJ; Xu Y; Warshawsky AM; Etgen GJ; Broderick CL; Clutinger CK; Irwin LA; Laurila ME; Montrose-Rafizadeh C; Oldham BA; Wang M; Winneroski LL; Xie C; York JS; Yumibe NP; Zink RW; Mantlo N
Bioorg Med Chem Lett; 2007 Dec; 17(24):6744-9. PubMed ID: 18029178
[TBL] [Abstract][Full Text] [Related]
13. Novel indole-based peroxisome proliferator-activated receptor agonists: design, SAR, structural biology, and biological activities.
Mahindroo N; Huang CF; Peng YH; Wang CC; Liao CC; Lien TW; Chittimalla SK; Huang WJ; Chai CH; Prakash E; Chen CP; Hsu TA; Peng CH; Lu IL; Lee LH; Chang YW; Chen WC; Chou YC; Chen CT; Goparaju CM; Chen YS; Lan SJ; Yu MC; Chen X; Chao YS; Wu SY; Hsieh HP
J Med Chem; 2005 Dec; 48(26):8194-208. PubMed ID: 16366601
[TBL] [Abstract][Full Text] [Related]
14. Indanylacetic acid derivatives carrying 4-thiazolyl-phenoxy tail groups, a new class of potent PPAR alpha/gamma/delta pan agonists: synthesis, structure-activity relationship, and in vivo efficacy.
Rudolph J; Chen L; Majumdar D; Bullock WH; Burns M; Claus T; Dela Cruz FE; Daly M; Ehrgott FJ; Johnson JS; Livingston JN; Schoenleber RW; Shapiro J; Yang L; Tsutsumi M; Ma X
J Med Chem; 2007 Mar; 50(5):984-1000. PubMed ID: 17274610
[TBL] [Abstract][Full Text] [Related]
15. Improvement of the transactivation activity of phenylpropanoic acid-type peroxisome proliferator-activated receptor pan agonists: effect of introduction of fluorine at the linker part.
Kasuga J; Oyama T; Hirakawa Y; Makishima M; Morikawa K; Hashimoto Y; Miyachi H
Bioorg Med Chem Lett; 2008 Aug; 18(16):4525-8. PubMed ID: 18662876
[TBL] [Abstract][Full Text] [Related]
16. Recent progress in research on peroxisome proliferator-activated receptor alpha-selective ligands.
Miyachi H
IDrugs; 2004 Aug; 7(8):746-54. PubMed ID: 15334308
[TBL] [Abstract][Full Text] [Related]
17. Selective peroxisome proliferator-activated receptor δ isosteric selenium agonists as potent anti-atherogenic agents in vivo.
Chin J; Hong JY; Lee J; Hwang H; Ko H; Choi H; Hahn D; Ko J; Nam SJ; Tak J; Ham J; Kang H
Bioorg Med Chem Lett; 2010 Dec; 20(24):7239-42. PubMed ID: 21074432
[TBL] [Abstract][Full Text] [Related]
18. Design, synthesis, and biological evaluation of novel potent and selective alphavbeta3/alphavbeta5 integrin dual inhibitors with improved bioavailability. Selection of the molecular core.
Marugán JJ; Manthey C; Anaclerio B; Lafrance L; Lu T; Markotan T; Leonard KA; Crysler C; Eisennagel S; Dasgupta M; Tomczuk B
J Med Chem; 2005 Feb; 48(4):926-34. PubMed ID: 15715463
[TBL] [Abstract][Full Text] [Related]
19. Design and synthesis of substituted phenylpropanoic acid derivatives as human peroxisome proliferator-activated receptor alpha/delta dual agonists.
Kasuga J; Makishima M; Hashimoto Y; Miyachi H
Bioorg Med Chem Lett; 2006 Feb; 16(3):554-8. PubMed ID: 16275077
[TBL] [Abstract][Full Text] [Related]
20. Structure-based design of indole propionic acids as novel PPARalpha/gamma co-agonists.
Kuhn B; Hilpert H; Benz J; Binggeli A; Grether U; Humm R; Märki HP; Meyer M; Mohr P
Bioorg Med Chem Lett; 2006 Aug; 16(15):4016-20. PubMed ID: 16737814
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
