These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

491 related articles for article (PubMed ID: 17524419)

  • 1. Crystal structures of tRNA-guanine transglycosylase (TGT) in complex with novel and potent inhibitors unravel pronounced induced-fit adaptations and suggest dimer formation upon substrate binding.
    Stengl B; Meyer EA; Heine A; Brenk R; Diederich F; Klebe G
    J Mol Biol; 2007 Jul; 370(3):492-511. PubMed ID: 17524419
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Flexible adaptations in the structure of the tRNA-modifying enzyme tRNA-guanine transglycosylase and their implications for substrate selectivity, reaction mechanism and structure-based drug design.
    Brenk R; Stubbs MT; Heine A; Reuter K; Klebe G
    Chembiochem; 2003 Oct; 4(10):1066-77. PubMed ID: 14523925
    [TBL] [Abstract][Full Text] [Related]  

  • 3. An integrative approach combining noncovalent mass spectrometry, enzyme kinetics and X-ray crystallography to decipher Tgt protein-protein and protein-RNA interaction.
    Ritschel T; Atmanene C; Reuter K; Van Dorsselaer A; Sanglier-Cianferani S; Klebe G
    J Mol Biol; 2009 Nov; 393(4):833-47. PubMed ID: 19627989
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mutagenesis and crystallographic studies of Zymomonas mobilis tRNA-guanine transglycosylase reveal aspartate 102 as the active site nucleophile.
    Romier C; Reuter K; Suck D; Ficner R
    Biochemistry; 1996 Dec; 35(49):15734-9. PubMed ID: 8961936
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Chemical trapping and crystal structure of a catalytic tRNA guanine transglycosylase covalent intermediate.
    Xie W; Liu X; Huang RH
    Nat Struct Biol; 2003 Oct; 10(10):781-8. PubMed ID: 12949492
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A new target for shigellosis: rational design and crystallographic studies of inhibitors of tRNA-guanine transglycosylase.
    Grädler U; Gerber HD; Goodenough-Lashua DM; Garcia GA; Ficner R; Reuter K; Stubbs MT; Klebe G
    J Mol Biol; 2001 Feb; 306(3):455-67. PubMed ID: 11178905
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Crystal structure analysis and in silico pKa calculations suggest strong pKa shifts of ligands as driving force for high-affinity binding to TGT.
    Ritschel T; Hoertner S; Heine A; Diederich F; Klebe G
    Chembiochem; 2009 Mar; 10(4):716-27. PubMed ID: 19199329
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Crystal structure of archaeosine tRNA-guanine transglycosylase.
    Ishitani R; Nureki O; Fukai S; Kijimoto T; Nameki N; Watanabe M; Kondo H; Sekine M; Okada N; Nishimura S; Yokoyama S
    J Mol Biol; 2002 May; 318(3):665-77. PubMed ID: 12054814
    [TBL] [Abstract][Full Text] [Related]  

  • 9. How to replace the residual solvation shell of polar active site residues to achieve nanomolar inhibition of tRNA-guanine transglycosylase.
    Ritschel T; Kohler PC; Neudert G; Heine A; Diederich F; Klebe G
    ChemMedChem; 2009 Dec; 4(12):2012-23. PubMed ID: 19894214
    [TBL] [Abstract][Full Text] [Related]  

  • 10. From lin-benzoguanines to lin-benzohypoxanthines as ligands for Zymomonas mobilis tRNA-guanine transglycosylase: replacement of protein-ligand hydrogen bonding by importing water clusters.
    Barandun LJ; Immekus F; Kohler PC; Tonazzi S; Wagner B; Wendelspiess S; Ritschel T; Heine A; Kansy M; Klebe G; Diederich F
    Chemistry; 2012 Jul; 18(30):9246-57. PubMed ID: 22736391
    [TBL] [Abstract][Full Text] [Related]  

  • 11. High-affinity inhibitors of Zymomonas mobilis tRNA-guanine transglycosylase through convergent optimization.
    Barandun LJ; Immekus F; Kohler PC; Ritschel T; Heine A; Orlando P; Klebe G; Diederich F
    Acta Crystallogr D Biol Crystallogr; 2013 Sep; 69(Pt 9):1798-807. PubMed ID: 23999303
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Investigation of specificity determinants in bacterial tRNA-guanine transglycosylase reveals queuine, the substrate of its eucaryotic counterpart, as inhibitor.
    Biela I; Tidten-Luksch N; Immekus F; Glinca S; Nguyen TX; Gerber HD; Heine A; Klebe G; Reuter K
    PLoS One; 2013; 8(5):e64240. PubMed ID: 23704982
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Soaking suggests "alternative facts": Only co-crystallization discloses major ligand-induced interface rearrangements of a homodimeric tRNA-binding protein indicating a novel mode-of-inhibition.
    Ehrmann FR; Stojko J; Metz A; Debaene F; Barandun LJ; Heine A; Diederich F; Cianférani S; Reuter K; Klebe G
    PLoS One; 2017; 12(4):e0175723. PubMed ID: 28419165
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Crystallographic study of inhibitors of tRNA-guanine transglycosylase suggests a new structure-based pharmacophore for virtual screening.
    Brenk R; Meyer EA; Reuter K; Stubbs MT; Garcia GA; Diederich F; Klebe G
    J Mol Biol; 2004 Apr; 338(1):55-75. PubMed ID: 15050823
    [TBL] [Abstract][Full Text] [Related]  

  • 15. tRNA-guanine transglycosylase from Escherichia coli. Overexpression, purification and quaternary structure.
    Garcia GA; Koch KA; Chong S
    J Mol Biol; 1993 May; 231(2):489-97. PubMed ID: 8323579
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Mutagenesis and crystallographic studies of Zymomonas mobilis tRNA-guanine transglycosylase to elucidate the role of serine 103 for enzymatic activity.
    Grädler U; Ficner R; Garcia GA; Stubbs MT; Klebe G; Reuter K
    FEBS Lett; 1999 Jul; 454(1-2):142-6. PubMed ID: 10413112
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Virtual screening for submicromolar leads of tRNA-guanine transglycosylase based on a new unexpected binding mode detected by crystal structure analysis.
    Brenk R; Naerum L; Grädler U; Gerber HD; Garcia GA; Reuter K; Stubbs MT; Klebe G
    J Med Chem; 2003 Mar; 46(7):1133-43. PubMed ID: 12646024
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Mechanism and substrate specificity of tRNA-guanine transglycosylases (TGTs): tRNA-modifying enzymes from the three different kingdoms of life share a common catalytic mechanism.
    Stengl B; Reuter K; Klebe G
    Chembiochem; 2005 Nov; 6(11):1926-39. PubMed ID: 16206323
    [TBL] [Abstract][Full Text] [Related]  

  • 19. X-ray absorption spectroscopy of the zinc site in tRNA-guanine transglycosylase from Escherichia coli.
    Garcia GA; Tierney DL; Chong S; Clark K; Penner-Hahn JE
    Biochemistry; 1996 Mar; 35(9):3133-9. PubMed ID: 8608154
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Crystal structure of tRNA-guanine transglycosylase: RNA modification by base exchange.
    Romier C; Reuter K; Suck D; Ficner R
    EMBO J; 1996 Jun; 15(11):2850-7. PubMed ID: 8654383
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 25.