260 related articles for article (PubMed ID: 17525473)
1. Protective efficacy of hGSTM1-1 against B[a]P and (+)- or (-)-B[a]P-7,8-dihydrodiol cytotoxicity, mutagenicity, and macromolecular adducts in V79 cells coexpressing hCYP1A1.
Kushman ME; Kabler SL; Ahmad S; Doehmer J; Morrow CS; Townsend AJ
Toxicol Sci; 2007 Sep; 99(1):51-7. PubMed ID: 17525473
[TBL] [Abstract][Full Text] [Related]
2. Expression of human glutathione S-transferase P1 confers resistance to benzo[a]pyrene or benzo[a]pyrene-7,8-dihydrodiol mutagenesis, macromolecular alkylation and formation of stable N2-Gua-BPDE adducts in stably transfected V79MZ cells co-expressing hCYP1A1.
Kushman ME; Kabler SL; Fleming MH; Ravoori S; Gupta RC; Doehmer J; Morrow CS; Townsend AJ
Carcinogenesis; 2007 Jan; 28(1):207-14. PubMed ID: 16885195
[TBL] [Abstract][Full Text] [Related]
3. Cytotoxicity and mutagenicity of dibenzo[a,l]pyrene and (+/-)-dibenzo[a,l]pyrene-11,12-dihydrodiol in V79MZ cells co-expressing either hCYP1A1 or hCYP1B1 together with human glutathione-S-transferase A1.
Kushman ME; Kabler SL; Ahmad S; Doehmer J; Morrow CS; Townsend AJ
Mutat Res; 2007 Nov; 624(1-2):80-7. PubMed ID: 17509623
[TBL] [Abstract][Full Text] [Related]
4. Cytotoxicity and mutagenicity of 5-methylchrysene and its 1,2-dihydrodiol in V79MZ cells modified to express human CYP1A1 or CYP1B1, in the presence or absence of human GSTP1 coexpression.
Ahmad S; Kabler SL; Rudd L; Amin S; Doehmer J; Morrow CS; Townsend AJ
Toxicol Lett; 2008 Dec; 183(1-3):99-104. PubMed ID: 18992797
[TBL] [Abstract][Full Text] [Related]
5. Differential protection by human glutathione S-transferase P1 against cytotoxicity of benzo[a]pyrene, dibenzo[a,l]pyrene, or their dihydrodiol metabolites, in bi-transgenic cell lines that co-express rat versus human cytochrome P4501A1.
Kabler SL; Seidel A; Jacob J; Doehmer J; Morrow CS; Townsend AJ
Chem Biol Interact; 2009 May; 179(2-3):240-6. PubMed ID: 19330882
[TBL] [Abstract][Full Text] [Related]
6. Mutagenic response of the endogenous hprt gene and lacI transgene in benzo[a]pyrene-treated Big Blue B6C3F1 mice.
Skopek TR; Kort KL; Marino DR; Mittal LV; Umbenhauer DR; Laws GM; Adams SP
Environ Mol Mutagen; 1996; 28(4):376-84. PubMed ID: 8991066
[TBL] [Abstract][Full Text] [Related]
7. The relationship between benzo(a)pyrene diol-epoxide-DNA adducts and mutagenicity in the CHO/HPGRT assay.
Recio L; Shugart LR; Hsie AW
Fundam Appl Toxicol; 1987 Feb; 8(2):243-52. PubMed ID: 3104121
[TBL] [Abstract][Full Text] [Related]
8. Hypoxia diminishes the detoxification of the environmental mutagen benzo[a]pyrene.
Schults MA; Sanen K; Godschalk RW; Theys J; van Schooten FJ; Chiu RK
Mutagenesis; 2014 Nov; 29(6):481-7. PubMed ID: 25199627
[TBL] [Abstract][Full Text] [Related]
9. Benzo(a)pyrene diolepoxide (BPDE)-DNA adduct levels in leukocytes of smokers in relation to polymorphism of CYP1A1, GSTM1, GSTP1, GSTT1, and mEH.
Lodovici M; Luceri C; Guglielmi F; Bacci C; Akpan V; Fonnesu ML; Boddi V; Dolara P
Cancer Epidemiol Biomarkers Prev; 2004 Aug; 13(8):1342-8. PubMed ID: 15298956
[TBL] [Abstract][Full Text] [Related]
10. Metabolic activation of the (+)-S,S- and (-)-R,R-enantiomers of trans-11,12-dihydroxy-11,12-dihydrodibenzo[a,l]pyrene: stereoselectivity, DNA adduct formation, and mutagenicity in Chinese hamster V79 cells.
Luch A; Seidel A; Glatt H; Platt KL
Chem Res Toxicol; 1997 Oct; 10(10):1161-70. PubMed ID: 9348439
[TBL] [Abstract][Full Text] [Related]
11. Differential mutagenicity and cytotoxicity of (+/-)-benzo[a]pyrene-trans-7,8-dihydrodiol and (+/-)-anti-benzo[a]pyrene-trans-7,8-dihydrodiol-9,10-epoxide in genetically engineered human fibroblasts.
Quan T; Reiners JJ; Culp SJ; Richter P; States JC
Mol Carcinog; 1995 Feb; 12(2):91-102. PubMed ID: 7662121
[TBL] [Abstract][Full Text] [Related]
12. Differential protection against benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced DNA damage in HepG2 cells stably transfected with allelic variants of pi class human glutathione S-transferase.
Hu X; Herzog C; Zimniak P; Singh SV
Cancer Res; 1999 May; 59(10):2358-62. PubMed ID: 10344744
[TBL] [Abstract][Full Text] [Related]
13. Sustained induction of cytochrome P4501A1 in human hepatoma cells by co-exposure to benzo[a]pyrene and 7H-dibenzo[c,g]carbazole underlies the synergistic effects on DNA adduct formation.
Gábelová A; Poláková V; Prochazka G; Kretová M; Poloncová K; Regendová E; Luciaková K; Segerbäck D
Toxicol Appl Pharmacol; 2013 Aug; 271(1):1-12. PubMed ID: 23639521
[TBL] [Abstract][Full Text] [Related]
14. Modeling the metabolic competency of glutathione S-transferases using genetically modified cell lines.
Townsend AJ; Kabler SL; Doehmer J; Morrow CS
Toxicology; 2002 Dec; 181-182():265-9. PubMed ID: 12505323
[TBL] [Abstract][Full Text] [Related]
15. A comparative investigation of DNA adducts, DNA strand breaks and gene mutations induced by benzo[a]pyrene and (+/-)-anti-benzo[a]pyrene-7,8-diol 9,10-oxide in cultured human cells.
Hanelt S; Helbig R; Hartmann A; Lang M; Seidel A; Speit G
Mutat Res; 1997 Apr; 390(1-2):179-88. PubMed ID: 9150767
[TBL] [Abstract][Full Text] [Related]
16. Modulative effects of metabolic effectors on benzo(a)pyrene-induced cytotoxicity and mutagenicity in mammalian cells.
Hsie AW; Recio L
Toxicol Ind Health; 1994; 10(3):181-9. PubMed ID: 7855867
[TBL] [Abstract][Full Text] [Related]
17. Molecular characterization of mutation and comparison of mutation profiles in the hprt gene of Chinese hamster ovary cells treated with benzo[a]pyrene trans-7,8-diol-anti-9,10-epoxide, 1-nitrobenzo[a]pyrene trans-7,8-diol-anti-9,10-epoxide, and 3-nitrobenzo[a]pyrene trans-7,8- diol-anti-9,10-epoxide.
Zhan DJ; Heflich RH; Fu PP
Environ Mol Mutagen; 1996; 27(1):19-29. PubMed ID: 8625944
[TBL] [Abstract][Full Text] [Related]
18. Modulation of the cytotoxicity and mutagenicity of benzo[a]pyrene and benzo[a]pyrene 7,8-diol by glutathione and glutathione S-transferases in mammalian cells (CHO/HGPRT assay).
Recio L; Hsie AW
Mutat Res; 1987 Jun; 178(2):257-69. PubMed ID: 3587256
[TBL] [Abstract][Full Text] [Related]
19. Roles of individual human cytochrome P-450 enzymes in the bioactivation of benzo(a)pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons.
Shimada T; Martin MV; Pruess-Schwartz D; Marnett LJ; Guengerich FP
Cancer Res; 1989 Nov; 49(22):6304-12. PubMed ID: 2509067
[TBL] [Abstract][Full Text] [Related]
20. Glycine N-methyltransferase tumor susceptibility gene in the benzo(a)pyrene-detoxification pathway.
Chen SY; Lin JR; Darbha R; Lin P; Liu TY; Chen YM
Cancer Res; 2004 May; 64(10):3617-23. PubMed ID: 15150120
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]