BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

162 related articles for article (PubMed ID: 17534577)

  • 1. In vitro chemosensitivity of freshly explanted tumor cells to pemetrexed is correlated with target gene expression.
    Hanauske AR; Eismann U; Oberschmidt O; Pospisil H; Hoffmann S; Hanauske-Abel H; Ma D; Chen V; Paoletti P; Niyikiza C
    Invest New Drugs; 2007 Oct; 25(5):417-23. PubMed ID: 17534577
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Reduced folate carrier and folylpolyglutamate synthetase, but not thymidylate synthase predict survival in pemetrexed-treated patients suffering from malignant pleural mesothelioma.
    Mairinger F; Vollbrecht C; Halbwedl I; Hatz M; Stacher E; Gülly C; Quehenberger F; Stephan-Falkenau S; Kollmeier J; Roth A; Mairinger T; Popper H
    J Thorac Oncol; 2013 May; 8(5):644-53. PubMed ID: 23449276
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Pemetrexed: mRNA expression of the target genes TS, GARFT and DHFR correlates with the in vitro chemosensitivity of human solid tumors.
    Eismann U; Oberschmidt O; Ehnert M; Fleeth J; Lüdtke FE; Struck S; Schulz L; Blatter J; Lahn MM; Ma D; Niyikiza C; Paoletti P; Hanauske AR
    Int J Clin Pharmacol Ther; 2005 Dec; 43(12):567-9. PubMed ID: 16372519
    [No Abstract]   [Full Text] [Related]  

  • 4. A phase II trial of pemetrexed in advanced breast cancer: clinical response and association with molecular target expression.
    Gomez HL; Santillana SL; Vallejos CS; Velarde R; Sanchez J; Wang X; Bauer NL; Hockett RD; Chen VJ; Niyikiza C; Hanauske AR
    Clin Cancer Res; 2006 Feb; 12(3 Pt 1):832-8. PubMed ID: 16467096
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Association between expression of thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase and efficacy of pemetrexed in advanced non-small cell lung cancer.
    Shimizu T; Nakanishi Y; Nakagawa Y; Tsujino I; Takahashi N; Nemoto N; Hashimoto S
    Anticancer Res; 2012 Oct; 32(10):4589-96. PubMed ID: 23060591
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Pharmacogenomic assessment of outcomes of pemetrexed-treated patients with adenocarcinoma of the lung.
    Jung M; Lee CH; Park HS; Lee JH; Kang YA; Kim SK; Chang J; Kim DJ; Rha SY; Kim JH; Cho BC
    Yonsei Med J; 2013 Jul; 54(4):854-64. PubMed ID: 23709418
    [TBL] [Abstract][Full Text] [Related]  

  • 7. LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes.
    Shih C; Chen VJ; Gossett LS; Gates SB; MacKellar WC; Habeck LL; Shackelford KA; Mendelsohn LG; Soose DJ; Patel VF; Andis SL; Bewley JR; Rayl EA; Moroson BA; Beardsley GP; Kohler W; Ratnam M; Schultz RM
    Cancer Res; 1997 Mar; 57(6):1116-23. PubMed ID: 9067281
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Establishment of pemetrexed-resistant non-small cell lung cancer cell lines.
    Zhang D; Ochi N; Takigawa N; Tanimoto Y; Chen Y; Ichihara E; Hotta K; Tabata M; Tanimoto M; Kiura K
    Cancer Lett; 2011 Oct; 309(2):228-35. PubMed ID: 21742432
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Preclinical cellular pharmacology of LY231514 (MTA): a comparison with methotrexate, LY309887 and raltitrexed for their effects on intracellular folate and nucleoside triphosphate pools in CCRF-CEM cells.
    Chen VJ; Bewley JR; Andis SL; Schultz RM; Iversen PW; Shih C; Mendelsohn LG; Seitz DE; Tonkinson JL
    Br J Cancer; 1998; 78 Suppl 3(Suppl 3):27-34. PubMed ID: 9717988
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Molecular mechanisms underlying the synergistic interaction of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, with the multitargeted antifolate pemetrexed in non-small-cell lung cancer cells.
    Giovannetti E; Lemos C; Tekle C; Smid K; Nannizzi S; Rodriguez JA; Ricciardi S; Danesi R; Giaccone G; Peters GJ
    Mol Pharmacol; 2008 Apr; 73(4):1290-300. PubMed ID: 18187583
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Induction of resistance to the multitargeted antifolate Pemetrexed (ALIMTA) in WiDr human colon cancer cells is associated with thymidylate synthase overexpression.
    Sigmond J; Backus HH; Wouters D; Temmink OH; Jansen G; Peters GJ
    Biochem Pharmacol; 2003 Aug; 66(3):431-8. PubMed ID: 12907242
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Molecular, biochemical, and cellular pharmacology of pemetrexed.
    Goldman ID; Zhao R
    Semin Oncol; 2002 Dec; 29(6 Suppl 18):3-17. PubMed ID: 12571805
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Significance of thymidylate synthase for resistance to pemetrexed in lung cancer.
    Ozasa H; Oguri T; Uemura T; Miyazaki M; Maeno K; Sato S; Ueda R
    Cancer Sci; 2010 Jan; 101(1):161-6. PubMed ID: 19811498
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Translational research with pemetrexed in breast cancer.
    Hanauske AR
    Oncology (Williston Park); 2004 Nov; 18(13 Suppl 8):66-9. PubMed ID: 15655941
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Thymidylate synthase and dihydrofolate reductase expression in non-small cell lung carcinoma: the association with treatment efficacy of pemetrexed.
    Chen CY; Chang YL; Shih JY; Lin JW; Chen KY; Yang CH; Yu CJ; Yang PC
    Lung Cancer; 2011 Oct; 74(1):132-8. PubMed ID: 21367480
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Protection of hematopoietic stem cells from pemetrexed toxicity by retroviral gene transfer with a mutant dihydrofolate reductase-mutant thymidylate synthase fusion gene.
    Capiaux GM; Budak-Alpdogan T; Alpdogan O; Bornmann W; Takebe N; Banerjee D; Maley F; Bertino JR
    Cancer Gene Ther; 2004 Dec; 11(12):767-73. PubMed ID: 15359285
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Decreased expression of the reduced folate carrier and folypolyglutamate synthetase is the basis for acquired resistance to the pemetrexed antifolate (LY231514) in an L1210 murine leukemia cell line.
    Wang Y; Zhao R; Goldman ID
    Biochem Pharmacol; 2003 Apr; 65(7):1163-70. PubMed ID: 12663051
    [TBL] [Abstract][Full Text] [Related]  

  • 18. TS, DHFR and GARFT expression in non-squamous cell carcinoma of NSCLC and malignant pleural mesothelioma patients treated with pemetrexed.
    Uramoto H; Onitsuka T; Shimokawa H; Hanagiri T
    Anticancer Res; 2010 Oct; 30(10):4309-15. PubMed ID: 21036757
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Cytotoxic effects of pemetrexed in gastric cancer cells.
    Kim JH; Lee KW; Jung Y; Kim TY; Ham HS; Jong HS; Jung KH; Im SA; Kim TY; Kim NK; Bang YJ
    Cancer Sci; 2005 Jun; 96(6):365-71. PubMed ID: 15958060
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines.
    Nannizzi S; Veal GJ; Giovannetti E; Mey V; Ricciardi S; Ottley CJ; Del Tacca M; Danesi R
    Cancer Chemother Pharmacol; 2010 Aug; 66(3):547-58. PubMed ID: 20020129
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.