279 related articles for article (PubMed ID: 17552508)
1. Design and synthesis of classical and nonclassical 6-arylthio-2,4-diamino-5-ethylpyrrolo[2,3-d]pyrimidines as antifolates.
Gangjee A; Zeng Y; Talreja T; McGuire JJ; Kisliuk RL; Queener SF
J Med Chem; 2007 Jun; 50(13):3046-53. PubMed ID: 17552508
[TBL] [Abstract][Full Text] [Related]
2. Dual inhibitors of thymidylate synthase and dihydrofolate reductase as antitumor agents: design, synthesis, and biological evaluation of classical and nonclassical pyrrolo[2,3-d]pyrimidine antifolates(1).
Gangjee A; Jain HD; Phan J; Lin X; Song X; McGuire JJ; Kisliuk RL
J Med Chem; 2006 Feb; 49(3):1055-65. PubMed ID: 16451071
[TBL] [Abstract][Full Text] [Related]
3. 2,4-Diamino-5-methyl-6-substituted arylthio-furo[2,3-d]pyrimidines as novel classical and nonclassical antifolates as potential dual thymidylate synthase and dihydrofolate reductase inhibitors.
Gangjee A; Jain HD; Phan J; Guo X; Queener SF; Kisliuk RL
Bioorg Med Chem; 2010 Jan; 18(2):953-61. PubMed ID: 20056546
[TBL] [Abstract][Full Text] [Related]
4. Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid and N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid as dual inhibitors of dihydrofolate reductase and thymidylate synthase and as potential antitumor agents.
Gangjee A; Lin X; Kisliuk RL; McGuire JJ
J Med Chem; 2005 Nov; 48(23):7215-22. PubMed ID: 16279780
[TBL] [Abstract][Full Text] [Related]
5. The effect of 5-alkyl modification on the biological activity of pyrrolo[2,3-d]pyrimidine containing classical and nonclassical antifolates as inhibitors of dihydrofolate reductase and as antitumor and/or antiopportunistic infection agents.
Gangjee A; Jain HD; Queener SF; Kisliuk RL
J Med Chem; 2008 Aug; 51(15):4589-600. PubMed ID: 18605720
[TBL] [Abstract][Full Text] [Related]
6. Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines.
Gangjee A; Vidwans A; Elzein E; McGuire JJ; Queener SF; Kisliuk RL
J Med Chem; 2001 Jun; 44(12):1993-2003. PubMed ID: 11384244
[TBL] [Abstract][Full Text] [Related]
7. 2,4-diamino-5-deaza-6-substituted pyrido[2,3-d]pyrimidine antifolates as potent and selective nonclassical inhibitors of dihydrofolate reductases.
Gangjee A; Vasudevan A; Queener SF; Kisliuk RL
J Med Chem; 1996 Mar; 39(7):1438-46. PubMed ID: 8691474
[TBL] [Abstract][Full Text] [Related]
8. Design, synthesis, and X-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent.
Gangjee A; Yu J; McGuire JJ; Cody V; Galitsky N; Kisliuk RL; Queener SF
J Med Chem; 2000 Oct; 43(21):3837-51. PubMed ID: 11052789
[TBL] [Abstract][Full Text] [Related]
9. Synthesis and biological activities of tricyclic conformationally restricted tetrahydropyrido annulated furo[2,3-d]pyrimidines as inhibitors of dihydrofolate reductases.
Gangjee A; Elzein E; Queener SF; McGuire JJ
J Med Chem; 1998 Apr; 41(9):1409-16. PubMed ID: 9554874
[TBL] [Abstract][Full Text] [Related]
10. Design, synthesis, and biological evaluation of classical and nonclassical 2-amino-4-oxo-5-substituted-6-methylpyrrolo[3,2-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors.
Gangjee A; Li W; Yang J; Kisliuk RL
J Med Chem; 2008 Jan; 51(1):68-76. PubMed ID: 18072727
[TBL] [Abstract][Full Text] [Related]
11. Nonclassical 2,4-diamino-5-aryl-6-ethylpyrimidine antifolates: activity as inhibitors of dihydrofolate reductase from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents.
Robson C; Meek MA; Grunwaldt JD; Lambert PA; Queener SF; Schmidt D; Griffin RJ
J Med Chem; 1997 Sep; 40(19):3040-8. PubMed ID: 9301666
[TBL] [Abstract][Full Text] [Related]
12. New 2,4-diamino-5-(2',5'-substituted benzyl)pyrimidines as potential drugs against opportunistic infections of AIDS and other immune disorders. Synthesis and species-dependent antifolate activity.
Rosowsky A; Forsch RA; Sibley CH; Inderlied CB; Queener SF
J Med Chem; 2004 Mar; 47(6):1475-86. PubMed ID: 14998335
[TBL] [Abstract][Full Text] [Related]
13. 6-Substituted 2,4-diaminopyrido[3,2-d]pyrimidine analogues of piritrexim as inhibitors of dihydrofolate reductase from rat liver, Pneumocystis carinii, and Toxoplasma gondii and as antitumor agents.
Gangjee A; Zhu Y; Queener SF
J Med Chem; 1998 Nov; 41(23):4533-41. PubMed ID: 9804692
[TBL] [Abstract][Full Text] [Related]
14. Synthesis and biological evaluation of 2,4-diamino-6-(arylaminomethyl)pyrido[2,3-d]pyrimidines as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase and as antiopportunistic infection and antitumor agents.
Gangjee A; Adair OO; Queener SF
J Med Chem; 2003 Nov; 46(23):5074-82. PubMed ID: 14584957
[TBL] [Abstract][Full Text] [Related]
15. Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents.
Gangjee A; Li W; Kisliuk RL; Cody V; Pace J; Piraino J; Makin J
J Med Chem; 2009 Aug; 52(15):4892-902. PubMed ID: 19719239
[TBL] [Abstract][Full Text] [Related]
16. Synthesis of 5-methyl-5-deaza nonclassical antifolates as inhibitors of dihydrofolate reductases and as potential antipneumocystis, antitoxoplasma, and antitumor agents.
Gangjee A; Shi J; Queener SF; Barrows LR; Kisliuk RL
J Med Chem; 1993 Oct; 36(22):3437-43. PubMed ID: 8230134
[TBL] [Abstract][Full Text] [Related]
17. Design, synthesis, and antifolate activity of new analogues of piritrexim and other diaminopyrimidine dihydrofolate reductase inhibitors with omega-carboxyalkoxy or omega-carboxy-1-alkynyl substitution in the side chain.
Chan DC; Fu H; Forsch RA; Queener SF; Rosowsky A
J Med Chem; 2005 Jun; 48(13):4420-31. PubMed ID: 15974594
[TBL] [Abstract][Full Text] [Related]
18. Targeting dihydrofolate reductase: Design, synthesis and biological evaluation of novel 6-substituted pyrrolo[2,3-d]pyrimidines as nonclassical antifolates and as potential antitumor agents.
Gao T; Zhang C; Shi X; Guo R; Zhang K; Gu J; Li L; Li S; Zheng Q; Cui M; Cui M; Gao X; Liu Y; Wang L
Eur J Med Chem; 2019 Sep; 178():329-340. PubMed ID: 31200235
[TBL] [Abstract][Full Text] [Related]
19. Inhibition of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductases by 2,4-diamino-5-[2-methoxy-5-(omega-carboxyalkyloxy)benzyl]pyrimidines: marked improvement in potency relative to trimethoprim and species selectivity relative to piritrexim.
Rosowsky A; Forsch RA; Queener SF
J Med Chem; 2002 Jan; 45(1):233-41. PubMed ID: 11754594
[TBL] [Abstract][Full Text] [Related]
20. Design, synthesis, and biological activities of classical N-[4-[2-(2-amino-4-ethylpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid and its 6-methyl derivative as potential dual inhibitors of thymidylate synthase and dihydrofolate reductase and as potential antitumor agents.
Gangjee A; Yu J; Kisliuk RL; Haile WH; Sobrero G; McGuire JJ
J Med Chem; 2003 Feb; 46(4):591-600. PubMed ID: 12570380
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
