245 related articles for article (PubMed ID: 17555301)
1. Allosteric mechanisms in cytochrome P450 3A4 studied by high-pressure spectroscopy: pivotal role of substrate-induced changes in the accessibility and degree of hydration of the heme pocket.
Davydov DR; Baas BJ; Sligar SG; Halpert JR
Biochemistry; 2007 Jul; 46(26):7852-64. PubMed ID: 17555301
[TBL] [Abstract][Full Text] [Related]
2. Conformational heterogeneity of cytochrome P450 3A4 revealed by high pressure spectroscopy.
Davydov DR; Halpert JR; Renaud JP; Hui Bon Hoa G
Biochem Biophys Res Commun; 2003 Dec; 312(1):121-30. PubMed ID: 14630029
[TBL] [Abstract][Full Text] [Related]
3. The thermodynamic landscape of testosterone binding to cytochrome P450 3A4: ligand binding and spin state equilibria.
Roberts AG; Campbell AP; Atkins WM
Biochemistry; 2005 Feb; 44(4):1353-66. PubMed ID: 15667229
[TBL] [Abstract][Full Text] [Related]
4. Resolution of multiple substrate binding sites in cytochrome P450 3A4: the stoichiometry of the enzyme-substrate complexes probed by FRET and Job's titration.
Fernando H; Halpert JR; Davydov DR
Biochemistry; 2006 Apr; 45(13):4199-209. PubMed ID: 16566594
[TBL] [Abstract][Full Text] [Related]
5. Allosteric transitions in cytochrome P450eryF explored with pressure-perturbation spectroscopy, lifetime FRET, and a novel fluorescent substrate, Fluorol-7GA.
Davydov DR; Davydova NY; Halpert JR
Biochemistry; 2008 Oct; 47(43):11348-59. PubMed ID: 18831537
[TBL] [Abstract][Full Text] [Related]
6. Pyrene.pyrene complexes at the active site of cytochrome P450 3A4: evidence for a multiple substrate binding site.
Dabrowski MJ; Schrag ML; Wienkers LC; Atkins WM
J Am Chem Soc; 2002 Oct; 124(40):11866-7. PubMed ID: 12358527
[TBL] [Abstract][Full Text] [Related]
7. An electrostatically driven conformational transition is involved in the mechanisms of substrate binding and cooperativity in cytochrome P450eryF.
Davydov DR; Botchkareva AE; Kumar S; He YQ; Halpert JR
Biochemistry; 2004 Jun; 43(21):6475-85. PubMed ID: 15157081
[TBL] [Abstract][Full Text] [Related]
8. Role of subunit interactions in P450 oligomers in the loss of homotropic cooperativity in the cytochrome P450 3A4 mutant L211F/D214E/F304W.
Fernando H; Davydov DR; Chin CC; Halpert JR
Arch Biochem Biophys; 2007 Apr; 460(1):129-40. PubMed ID: 17274942
[TBL] [Abstract][Full Text] [Related]
9. Dynamics of protein-bound water in the heme domain of P450BM3 studied by high-pressure spectroscopy: comparison with P450cam and P450 2B4.
Davydov DR; Hui Bon Hoa G; Peterson JA
Biochemistry; 1999 Jan; 38(2):751-61. PubMed ID: 9888815
[TBL] [Abstract][Full Text] [Related]
10. Mechanism of interactions of alpha-naphthoflavone with cytochrome P450 3A4 explored with an engineered enzyme bearing a fluorescent probe.
Tsalkova TN; Davydova NY; Halpert JR; Davydov DR
Biochemistry; 2007 Jan; 46(1):106-19. PubMed ID: 17198380
[TBL] [Abstract][Full Text] [Related]
11. A large-scale allosteric transition in cytochrome P450 3A4 revealed by luminescence resonance energy transfer (LRET).
Sineva EV; Rumfeldt JA; Halpert JR; Davydov DR
PLoS One; 2013; 8(12):e83898. PubMed ID: 24376769
[TBL] [Abstract][Full Text] [Related]
12. Heme-pocket-hydration change during the inactivation of cytochrome P-450camphor by hydrostatic pressure.
Di Primo C; Hui Bon Hoa G; Douzou P; Sligar SG
Eur J Biochem; 1992 Oct; 209(2):583-8. PubMed ID: 1425665
[TBL] [Abstract][Full Text] [Related]
13. The use of isomeric testosterone dimers to explore allosteric effects in substrate binding to cytochrome P450 CYP3A4.
Denisov IG; Mak PJ; Grinkova YV; Bastien D; Bérubé G; Sligar SG; Kincaid JR
J Inorg Biochem; 2016 May; 158():77-85. PubMed ID: 26774838
[TBL] [Abstract][Full Text] [Related]
14. The one-electron autoxidation of human cytochrome P450 3A4.
Denisov IG; Grinkova YV; McLean MA; Sligar SG
J Biol Chem; 2007 Sep; 282(37):26865-26873. PubMed ID: 17650504
[TBL] [Abstract][Full Text] [Related]
15. Energetics of heterotropic cooperativity between alpha-naphthoflavone and testosterone binding to CYP3A4.
Roberts AG; Atkins WM
Arch Biochem Biophys; 2007 Jul; 463(1):89-101. PubMed ID: 17459328
[TBL] [Abstract][Full Text] [Related]
16. Cooperativity in cytochrome P450 3A4: linkages in substrate binding, spin state, uncoupling, and product formation.
Denisov IG; Baas BJ; Grinkova YV; Sligar SG
J Biol Chem; 2007 Mar; 282(10):7066-76. PubMed ID: 17213193
[TBL] [Abstract][Full Text] [Related]
17. Flexibility of human cytochrome P450 enzymes: molecular dynamics and spectroscopy reveal important function-related variations.
Hendrychová T; Anzenbacherová E; Hudeček J; Skopalík J; Lange R; Hildebrandt P; Otyepka M; Anzenbacher P
Biochim Biophys Acta; 2011 Jan; 1814(1):58-68. PubMed ID: 20656072
[TBL] [Abstract][Full Text] [Related]
18. Coexpression of genetically engineered fused enzyme between yeast NADPH-P450 reductase and human cytochrome P450 3A4 and human cytochrome b5 in yeast.
Hayashi K; Sakaki T; Kominami S; Inouye K; Yabusaki Y
Arch Biochem Biophys; 2000 Sep; 381(1):164-70. PubMed ID: 11019832
[TBL] [Abstract][Full Text] [Related]
19. Electron transfer in the complex of membrane-bound human cytochrome P450 3A4 with the flavin domain of P450BM-3: the effect of oligomerization of the heme protein and intermittent modulation of the spin equilibrium.
Davydov DR; Sineva EV; Sistla S; Davydova NY; Frank DJ; Sligar SG; Halpert JR
Biochim Biophys Acta; 2010 Mar; 1797(3):378-90. PubMed ID: 20026040
[TBL] [Abstract][Full Text] [Related]
20. Conformational Mobility in Cytochrome P450 3A4 Explored by Pressure-Perturbation EPR Spectroscopy.
Davydov DR; Yang Z; Davydova N; Halpert JR; Hubbell WL
Biophys J; 2016 Apr; 110(7):1485-1498. PubMed ID: 27074675
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
