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2. Use of pharmacoperones to reveal GPCR structural changes associated with constitutive activation and trafficking. Janovick JA; Conn PM Methods Enzymol; 2010; 485():277-92. PubMed ID: 21050923 [TBL] [Abstract][Full Text] [Related]
3. Human loss-of-function gonadotropin-releasing hormone receptor mutants retain wild-type receptors in the endoplasmic reticulum: molecular basis of the dominant-negative effect. Brothers SP; Cornea A; Janovick JA; Conn PM Mol Endocrinol; 2004 Jul; 18(7):1787-97. PubMed ID: 15105440 [TBL] [Abstract][Full Text] [Related]
4. Therapeutic rescue of misfolded mutants: validation of primary high throughput screens for identification of pharmacoperone drugs. Janovick JA; Park BS; Conn PM PLoS One; 2011; 6(7):e22784. PubMed ID: 21818389 [TBL] [Abstract][Full Text] [Related]
5. Rescue of hypogonadotropic hypogonadism-causing and manufactured GnRH receptor mutants by a specific protein-folding template: misrouted proteins as a novel disease etiology and therapeutic target. Janovick JA; Maya-Nunez G; Conn PM J Clin Endocrinol Metab; 2002 Jul; 87(7):3255-62. PubMed ID: 12107234 [TBL] [Abstract][Full Text] [Related]
6. Restoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy. Janovick JA; Stewart MD; Jacob D; Martin LD; Deng JM; Stewart CA; Wang Y; Cornea A; Chavali L; Lopez S; Mitalipov S; Kang E; Lee HS; Manna PR; Stocco DM; Behringer RR; Conn PM Proc Natl Acad Sci U S A; 2013 Dec; 110(52):21030-5. PubMed ID: 24324164 [TBL] [Abstract][Full Text] [Related]
7. Regulation of G protein-coupled receptor trafficking by inefficient plasma membrane expression: molecular basis of an evolved strategy. Janovick JA; Knollman PE; Brothers SP; Ayala-Yáñez R; Aziz AS; Conn PM J Biol Chem; 2006 Mar; 281(13):8417-25. PubMed ID: 16446355 [TBL] [Abstract][Full Text] [Related]
8. Structure-activity relations of successful pharmacologic chaperones for rescue of naturally occurring and manufactured mutants of the gonadotropin-releasing hormone receptor. Janovick JA; Goulet M; Bush E; Greer J; Wettlaufer DG; Conn PM J Pharmacol Exp Ther; 2003 May; 305(2):608-14. PubMed ID: 12606630 [TBL] [Abstract][Full Text] [Related]
10. Drug development and the cellular quality control system. Conn PM; Janovick JA Trends Pharmacol Sci; 2009 May; 30(5):228-33. PubMed ID: 19307028 [TBL] [Abstract][Full Text] [Related]
11. Therapeutic rescue of misfolded/mistrafficked mutants: automation-friendly high-throughput assays for identification of pharmacoperone drugs of GPCRs. Smithson DC; Janovick JA; Conn PM Methods Enzymol; 2013; 521():3-16. PubMed ID: 23351731 [TBL] [Abstract][Full Text] [Related]
12. Dominant-negative action of disease-causing gonadotropin-releasing hormone receptor (GnRHR) mutants: a trait that potentially coevolved with decreased plasma membrane expression of GnRHR in humans. Leaños-Miranda A; Ulloa-Aguirre A; Ji TH; Janovick JA; Conn PM J Clin Endocrinol Metab; 2003 Jul; 88(7):3360-7. PubMed ID: 12843188 [TBL] [Abstract][Full Text] [Related]
13. Trafficking of G-protein-coupled receptors to the plasma membrane: insights for pharmacoperone drugs. Conn PM; Ulloa-Aguirre A Trends Endocrinol Metab; 2010 Mar; 21(3):190-7. PubMed ID: 20005736 [TBL] [Abstract][Full Text] [Related]
14. Pharmacological chaperones correct misfolded GPCRs and rescue function: protein trafficking as a therapeutic target. Maya-Núñez G; Ulloa-Aguirre A; Janovick JA; Conn PM Subcell Biochem; 2012; 63():263-89. PubMed ID: 23161143 [TBL] [Abstract][Full Text] [Related]
15. Pharmacoperones: a new therapeutic approach for diseases caused by misfolded G protein-coupled receptors. Ulloa-Aguirre A; Michael Conn P Recent Pat Endocr Metab Immune Drug Discov; 2011 Jan; 5(1):13-24. PubMed ID: 22074574 [TBL] [Abstract][Full Text] [Related]
16. G protein-coupled receptor trafficking in health and disease: lessons learned to prepare for therapeutic mutant rescue in vivo. Conn PM; Ulloa-Aguirre A; Ito J; Janovick JA Pharmacol Rev; 2007 Sep; 59(3):225-50. PubMed ID: 17878512 [TBL] [Abstract][Full Text] [Related]
19. Pharmacoperones as a New Therapeutic Approach: In Vitro Identification and In vivo Validation of Bioactive Molecules. Ulloa-Aguirre A; Conn PM Curr Drug Targets; 2016; 17(13):1471-81. PubMed ID: 26953247 [TBL] [Abstract][Full Text] [Related]