These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

156 related articles for article (PubMed ID: 17566736)

  • 1. Design, synthesis, and biological evaluation of pyrazinones containing novel P1 needles as inhibitors of TF/VIIa.
    Trujillo JI; Huang HC; Neumann WL; Mahoney MW; Long S; Huang W; Garland DJ; Kusturin C; Abbas Z; South MS; Reitz DB
    Bioorg Med Chem Lett; 2007 Aug; 17(16):4568-74. PubMed ID: 17566736
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design, parallel synthesis, and crystal structures of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex.
    Parlow JJ; Case BL; Dice TA; Fenton RL; Hayes MJ; Jones DE; Neumann WL; Wood RS; Lachance RM; Girard TJ; Nicholson NS; Clare M; Stegeman RA; Stevens AM; Stallings WC; Kurumbail RG; South MS
    J Med Chem; 2003 Sep; 46(19):4050-62. PubMed ID: 12954058
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors.
    Zbinden KG; Obst-Sander U; Hilpert K; Kühne H; Banner DW; Böhm HJ; Stahl M; Ackermann J; Alig L; Weber L; Wessel HP; Riederer MA; Tschopp TB; Lavé T
    Bioorg Med Chem Lett; 2005 Dec; 15(23):5344-52. PubMed ID: 16213138
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design, synthesis and biological activity of selective and orally available TF/FVIIa complex inhibitors containing non-amidine P1 ligands.
    Miura M; Seki N; Koike T; Ishihara T; Niimi T; Hirayama F; Shigenaga T; Sakai-Moritani Y; Tagawa A; Kawasaki T; Sakamoto S; Okada M; Ohta M; Tsukamoto S
    Bioorg Med Chem; 2007 Jan; 15(1):160-73. PubMed ID: 17064913
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Potent and selective TF/FVIIa inhibitors containing a neutral P1 ligand.
    Miura M; Seki N; Koike T; Ishihara T; Niimi T; Hirayama F; Shigenaga T; Sakai-Moritani Y; Kawasaki T; Sakamoto S; Okada M; Ohta M; Tsukamoto S
    Bioorg Med Chem; 2006 Dec; 14(23):7688-705. PubMed ID: 16942884
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Inhibitors of Factor VIIa/tissue factor.
    Shirk RA; Vlasuk GP
    Arterioscler Thromb Vasc Biol; 2007 Sep; 27(9):1895-900. PubMed ID: 17600222
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Discovery of a Highly Potent, Selective, and Orally Bioavailable Macrocyclic Inhibitor of Blood Coagulation Factor VIIa-Tissue Factor Complex.
    Zhang X; Glunz PW; Johnson JA; Jiang W; Jacutin-Porte S; Ladziata V; Zou Y; Phillips MS; Wurtz NR; Parkhurst B; Rendina AR; Harper TM; Cheney DL; Luettgen JM; Wong PC; Seiffert D; Wexler RR; Priestley ES
    J Med Chem; 2016 Aug; 59(15):7125-37. PubMed ID: 27455395
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design, parallel synthesis, and crystal structures of biphenyl antithrombotics as selective inhibitors of tissue factor FVIIa complex. Part 1: Exploration of S2 pocket pharmacophores.
    Kotian PL; Krishnan R; Rowland S; El-Kattan Y; Saini SK; Upshaw R; Bantia S; Arnold S; Babu YS; Chand P
    Bioorg Med Chem; 2009 Jun; 17(11):3934-58. PubMed ID: 19409795
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Dose-dependent antithrombotic activity of an orally active tissue factor/factor VIIa inhibitor without concomitant enhancement of bleeding propensity.
    Groebke Zbinden K; Banner DW; Hilpert K; Himber J; Lavé T; Riederer MA; Stahl M; Tschopp TB; Obst-Sander U
    Bioorg Med Chem; 2006 Aug; 14(15):5357-69. PubMed ID: 16621574
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structure-based design and synthesis of pyrazinones containing novel P1 'side pocket' moieties as inhibitors of TF/VIIa.
    Schweitzer BA; Neumann WL; Rahman HK; Kusturin CL; Sample KR; Poda GI; Kurumbail RG; Stevens AM; Stegeman RA; Stallings WC; South MS
    Bioorg Med Chem Lett; 2005 Jun; 15(12):3006-11. PubMed ID: 15913999
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Design, synthesis, and biological evaluation of 1,5-benzothiazepine-4-one derivatives targeting factor VIIa/tissue factor.
    Ayral E; Gloanec P; Bergé G; de Nanteuil G; Mennecier P; Rupin A; Verbeuren TJ; Fulcrand P; Martinez J; Hernandez JF
    Bioorg Med Chem Lett; 2009 Mar; 19(5):1386-91. PubMed ID: 19181521
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The discovery of fluoropyridine-based inhibitors of the factor VIIa/TF complex--Part 2.
    Kohrt JT; Filipski KJ; Cody WL; Cai C; Dudley DA; Van Huis CA; Willardsen JA; Narasimhan LS; Zhang E; Rapundalo ST; Saiya-Cork K; Leadley RJ; Edmunds JJ
    Bioorg Med Chem Lett; 2006 Feb; 16(4):1060-4. PubMed ID: 16289811
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Factor VIIa inhibitors: a prodrug strategy to improve oral bioavailability.
    Riggs JR; Kolesnikov A; Hendrix J; Young WB; Shrader WD; Vijaykumar D; Stephens R; Liu L; Pan L; Mordenti J; Green MJ; Sukbuntherng J
    Bioorg Med Chem Lett; 2006 Apr; 16(8):2224-8. PubMed ID: 16458507
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Efforts toward oral bioavailability in factor VIIa inhibitors.
    Vijaykumar D; Rai R; Shaghafi M; Ton T; Torkelson S; Leahy EM; Riggs JR; Hu H; Sprengeler PA; Shrader WD; O'Bryan C; Cabuslay R; Sanford E; Gjerstadt E; Liu L; Sukbuntherng J; Young WB
    Bioorg Med Chem Lett; 2006 Jul; 16(14):3829-32. PubMed ID: 16650987
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors.
    Groebke Zbinden K; Banner DW; Ackermann J; D'Arcy A; Kirchhofer D; Ji YH; Tschopp TB; Wallbaum S; Weber L
    Bioorg Med Chem Lett; 2005 Feb; 15(3):817-22. PubMed ID: 15664864
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Inhibitors of the tissue factor/factor VIIa-induced coagulation: synthesis and in vitro evaluation of novel 2-aryl substituted pyrid.
    Jakobsen P; Horneman AM; Persson E
    Bioorg Med Chem; 2000 Dec; 8(12):2803-12. PubMed ID: 11131171
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Optimization of a coagulation factor VIIa inhibitor found in factor Xa inhibitor library.
    Sagi K; Fujita K; Sugiki M; Takahashi M; Takehana S; Tashiro K; Kayahara T; Yamanashi M; Fukuda Y; Oono S; Okajima A; Iwata S; Shoji M; Sakurai K
    Bioorg Med Chem; 2005 Mar; 13(5):1487-96. PubMed ID: 15698764
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discovery of novel heterocyclic factor VIIa inhibitors.
    Rai R; Kolesnikov A; Sprengeler PA; Torkelson S; Ton T; Katz BA; Yu C; Hendrix J; Shrader WD; Stephens R; Cabuslay R; Sanford E; Young WB
    Bioorg Med Chem Lett; 2006 Apr; 16(8):2270-3. PubMed ID: 16460932
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Probing the S2 site of factor VIIa to generate potent and selective inhibitors: the structure of BCX-3607 in complex with tissue factor-factor VIIa.
    Krishnan R; Kotian PL; Chand P; Bantia S; Rowland S; Babu YS
    Acta Crystallogr D Biol Crystallogr; 2007 Jun; 63(Pt 6):689-97. PubMed ID: 17505107
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structure-based design of P3 moieties in the peptide mimetic factor VIIa inhibitor.
    Kadono S; Sakamoto A; Kikuchi Y; Oh-eda M; Yabuta N; Yoshihashi K; Kitazawa T; Suzuki T; Koga T; Hattori K; Shiraishi T; Haramura M; Kodama H; Ono Y; Esaki T; Sato H; Watanabe Y; Itoh S; Ohta M; Kozono T
    Biochem Biophys Res Commun; 2005 Feb; 327(2):589-96. PubMed ID: 15629154
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.