BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

133 related articles for article (PubMed ID: 17567119)

  • 1. Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II.
    Barinka C; Rovenská M; Mlcochová P; Hlouchová K; Plechanovová A; Majer P; Tsukamoto T; Slusher BS; Konvalinka J; Lubkowski J
    J Med Chem; 2007 Jul; 50(14):3267-73. PubMed ID: 17567119
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structural basis of interactions between human glutamate carboxypeptidase II and its substrate analogs.
    Barinka C; Hlouchova K; Rovenska M; Majer P; Dauter M; Hin N; Ko YS; Tsukamoto T; Slusher BS; Konvalinka J; Lubkowski J
    J Mol Biol; 2008 Mar; 376(5):1438-50. PubMed ID: 18234225
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Human glutamate carboxypeptidase II inhibition: structures of GCPII in complex with two potent inhibitors, quisqualate and 2-PMPA.
    Mesters JR; Henning K; Hilgenfeld R
    Acta Crystallogr D Biol Crystallogr; 2007 Apr; 63(Pt 4):508-13. PubMed ID: 17372356
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III.
    Hlouchova K; Barinka C; Konvalinka J; Lubkowski J
    FEBS J; 2009 Aug; 276(16):4448-62. PubMed ID: 19678840
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Molecular modeling of the interactions of glutamate carboxypeptidase II with its potent NAAG-based inhibitors.
    Rong SB; Zhang J; Neale JH; Wroblewski JT; Wang S; Kozikowski AP
    J Med Chem; 2002 Sep; 45(19):4140-52. PubMed ID: 12213057
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer.
    Mesters JR; Barinka C; Li W; Tsukamoto T; Majer P; Slusher BS; Konvalinka J; Hilgenfeld R
    EMBO J; 2006 Mar; 25(6):1375-84. PubMed ID: 16467855
    [TBL] [Abstract][Full Text] [Related]  

  • 7. S1 pocket of glutamate carboxypeptidase II: a new binding site for amyloid-β degradation.
    Lee SK; Kim H; Cheong YH; Kim MJ; Jo SA; Youn HS; Park SI
    Biochem Biophys Res Commun; 2013 Sep; 438(4):765-71. PubMed ID: 23891752
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Glutamate carboxypeptidase II: an overview of structural studies and their importance for structure-based drug design and deciphering the reaction mechanism of the enzyme.
    Pavlícek J; Ptácek J; Barinka C
    Curr Med Chem; 2012; 19(9):1300-9. PubMed ID: 22304708
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Design of composite inhibitors targeting glutamate carboxypeptidase II: the importance of effector functionalities.
    Novakova Z; Cerny J; Choy CJ; Nedrow JR; Choi JK; Lubkowski J; Berkman CE; Barinka C
    FEBS J; 2016 Jan; 283(1):130-43. PubMed ID: 26460595
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis of urea-based inhibitors as active site probes of glutamate carboxypeptidase II: efficacy as analgesic agents.
    Kozikowski AP; Zhang J; Nan F; Petukhov PA; Grajkowska E; Wroblewski JT; Yamamoto T; Bzdega T; Wroblewska B; Neale JH
    J Med Chem; 2004 Mar; 47(7):1729-38. PubMed ID: 15027864
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Mapping of the active site of glutamate carboxypeptidase II by site-directed mutagenesis.
    Mlcochová P; Plechanovová A; Barinka C; Mahadevan D; Saldanha JW; Rulísek L; Konvalinka J
    FEBS J; 2007 Sep; 274(18):4731-41. PubMed ID: 17714508
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Novel substrate-based inhibitors of human glutamate carboxypeptidase II with enhanced lipophilicity.
    Plechanovová A; Byun Y; Alquicer G; Skultétyová L; Mlčochová P; Němcová A; Kim HJ; Navrátil M; Mease R; Lubkowski J; Pomper M; Konvalinka J; Rulíšek L; Bařinka C
    J Med Chem; 2011 Nov; 54(21):7535-46. PubMed ID: 21923190
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structural characterization of P1'-diversified urea-based inhibitors of glutamate carboxypeptidase II.
    Pavlicek J; Ptacek J; Cerny J; Byun Y; Skultetyova L; Pomper MG; Lubkowski J; Barinka C
    Bioorg Med Chem Lett; 2014 May; 24(10):2340-5. PubMed ID: 24731280
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A high-resolution structure of ligand-free human glutamate carboxypeptidase II.
    Barinka C; Starkova J; Konvalinka J; Lubkowski J
    Acta Crystallogr Sect F Struct Biol Cryst Commun; 2007 Mar; 63(Pt 3):150-3. PubMed ID: 17329803
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Interactions between human glutamate carboxypeptidase II and urea-based inhibitors: structural characterization.
    Barinka C; Byun Y; Dusich CL; Banerjee SR; Chen Y; Castanares M; Kozikowski AP; Mease RC; Pomper MG; Lubkowski J
    J Med Chem; 2008 Dec; 51(24):7737-43. PubMed ID: 19053759
    [TBL] [Abstract][Full Text] [Related]  

  • 16. In silico approaches to identify the potential inhibitors of glutamate carboxypeptidase II (GCPII) for neuroprotection.
    Naushad SM; Janaki Ramaiah M; Stanley BA; Prasanna Lakshmi S; Vishnu Priya J; Hussain T; Alrokayan SA; Kutala VK
    J Theor Biol; 2016 Oct; 406():137-42. PubMed ID: 27430729
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structural and biochemical characterization of the folyl-poly-γ-l-glutamate hydrolyzing activity of human glutamate carboxypeptidase II.
    Navrátil M; Ptáček J; Šácha P; Starková J; Lubkowski J; Bařinka C; Konvalinka J
    FEBS J; 2014 Jul; 281(14):3228-42. PubMed ID: 24863754
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Design of highly potent urea-based, exosite-binding inhibitors selective for glutamate carboxypeptidase II.
    Tykvart J; Schimer J; Jančařík A; Bařinková J; Navrátil V; Starková J; Šrámková K; Konvalinka J; Majer P; Šácha P
    J Med Chem; 2015 May; 58(10):4357-63. PubMed ID: 25923815
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Rational design of urea-based glutamate carboxypeptidase II (GCPII) inhibitors as versatile tools for specific drug targeting and delivery.
    Tykvart J; Schimer J; Bařinková J; Pachl P; Poštová-Slavětínská L; Majer P; Konvalinka J; Šácha P
    Bioorg Med Chem; 2014 Aug; 22(15):4099-108. PubMed ID: 24954515
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Unprecedented Binding Mode of Hydroxamate-Based Inhibitors of Glutamate Carboxypeptidase II: Structural Characterization and Biological Activity.
    Novakova Z; Wozniak K; Jancarik A; Rais R; Wu Y; Pavlicek J; Ferraris D; Havlinova B; Ptacek J; Vavra J; Hin N; Rojas C; Majer P; Slusher BS; Tsukamoto T; Barinka C
    J Med Chem; 2016 May; 59(10):4539-50. PubMed ID: 27074627
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.