221 related articles for article (PubMed ID: 17569517)
1. Novel boron-containing, nonclassical antifolates: synthesis and preliminary biological and structural evaluation.
Reynolds RC; Campbell SR; Fairchild RG; Kisliuk RL; Micca PL; Queener SF; Riordan JM; Sedwick WD; Waud WR; Leung AK; Dixon RW; Suling WJ; Borhani DW
J Med Chem; 2007 Jul; 50(14):3283-9. PubMed ID: 17569517
[TBL] [Abstract][Full Text] [Related]
2. 2,4-diamino-5-deaza-6-substituted pyrido[2,3-d]pyrimidine antifolates as potent and selective nonclassical inhibitors of dihydrofolate reductases.
Gangjee A; Vasudevan A; Queener SF; Kisliuk RL
J Med Chem; 1996 Mar; 39(7):1438-46. PubMed ID: 8691474
[TBL] [Abstract][Full Text] [Related]
3. Lipophilic antifolates as agents against opportunistic infections. 1. Agents superior to trimetrexate and piritrexim against Toxoplasma gondii and Pneumocystis carinii in in vitro evaluations.
Piper JR; Johnson CA; Krauth CA; Carter RL; Hosmer CA; Queener SF; Borotz SE; Pfefferkorn ER
J Med Chem; 1996 Mar; 39(6):1271-80. PubMed ID: 8632434
[TBL] [Abstract][Full Text] [Related]
4. Nonclassical 2,4-diamino-5-aryl-6-ethylpyrimidine antifolates: activity as inhibitors of dihydrofolate reductase from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents.
Robson C; Meek MA; Grunwaldt JD; Lambert PA; Queener SF; Schmidt D; Griffin RJ
J Med Chem; 1997 Sep; 40(19):3040-8. PubMed ID: 9301666
[TBL] [Abstract][Full Text] [Related]
5. Further studies on 2,4-diamino-5-(2',5'-disubstituted benzyl)pyrimidines as potent and selective inhibitors of dihydrofolate reductases from three major opportunistic pathogens of AIDS.
Rosowsky A; Forsch RA; Queener SF
J Med Chem; 2003 Apr; 46(9):1726-36. PubMed ID: 12699390
[TBL] [Abstract][Full Text] [Related]
6. Structure-based design and synthesis of lipophilic 2,4-diamino-6-substituted quinazolines and their evaluation as inhibitors of dihydrofolate reductases and potential antitumor agents.
Gangjee A; Vidwans AP; Vasudevan A; Queener SF; Kisliuk RL; Cody V; Li R; Galitsky N; Luft JR; Pangborn W
J Med Chem; 1998 Aug; 41(18):3426-34. PubMed ID: 9719595
[TBL] [Abstract][Full Text] [Related]
7. Selective Pneumocystis carinii dihydrofolate reductase inhibitors: design, synthesis, and biological evaluation of new 2,4-diamino-5-substituted-furo[2,3-d]pyrimidines.
Gangjee A; Guo X; Queener SF; Cody V; Galitsky N; Luft JR; Pangborn W
J Med Chem; 1998 Apr; 41(8):1263-71. PubMed ID: 9548816
[TBL] [Abstract][Full Text] [Related]
8. Design, synthesis, and biological evaluation of 2,4-diamino-5-methyl-6-substituted-pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors.
Gangjee A; Lin X; Queener SF
J Med Chem; 2004 Jul; 47(14):3689-92. PubMed ID: 15214795
[TBL] [Abstract][Full Text] [Related]
9. Synthesis and biological evaluation of 2,4-diamino-6-(arylaminomethyl)pyrido[2,3-d]pyrimidines as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase and as antiopportunistic infection and antitumor agents.
Gangjee A; Adair OO; Queener SF
J Med Chem; 2003 Nov; 46(23):5074-82. PubMed ID: 14584957
[TBL] [Abstract][Full Text] [Related]
10. 2,4-Diaminothieno[2,3-d]pyrimidine lipophilic antifolates as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.
Rosowsky A; Papoulis AT; Queener SF
J Med Chem; 1997 Oct; 40(22):3694-9. PubMed ID: 9357537
[TBL] [Abstract][Full Text] [Related]
11. New 2,4-diamino-5-(2',5'-substituted benzyl)pyrimidines as potential drugs against opportunistic infections of AIDS and other immune disorders. Synthesis and species-dependent antifolate activity.
Rosowsky A; Forsch RA; Sibley CH; Inderlied CB; Queener SF
J Med Chem; 2004 Mar; 47(6):1475-86. PubMed ID: 14998335
[TBL] [Abstract][Full Text] [Related]
12. Synthesis and biological activities of conformationally restricted, tricyclic nonclassical antifolates as inhibitors of dihydrofolate reductases.
Gangjee A; Shi J; Queener SF
J Med Chem; 1997 Jun; 40(12):1930-6. PubMed ID: 9191971
[TBL] [Abstract][Full Text] [Related]
13. Design, synthesis, biological evaluation and computational investigation of novel inhibitors of dihydrofolate reductase of opportunistic pathogens.
Bag S; Tawari NR; Degani MS; Queener SF
Bioorg Med Chem; 2010 May; 18(9):3187-97. PubMed ID: 20363634
[TBL] [Abstract][Full Text] [Related]
14. Synthesis and biological activities of tricyclic conformationally restricted tetrahydropyrido annulated furo[2,3-d]pyrimidines as inhibitors of dihydrofolate reductases.
Gangjee A; Elzein E; Queener SF; McGuire JJ
J Med Chem; 1998 Apr; 41(9):1409-16. PubMed ID: 9554874
[TBL] [Abstract][Full Text] [Related]
15. Synthesis of 2,4-diamino-6-[2'-O-(omega-carboxyalkyl)oxydibenz[b,f]azepin-5-yl]methylpteridines as potent and selective inhibitors of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductase.
Rosowsky A; Fu H; Chan DC; Queener SF
J Med Chem; 2004 May; 47(10):2475-85. PubMed ID: 15115391
[TBL] [Abstract][Full Text] [Related]
16. Design, synthesis, and antifolate activity of new analogues of piritrexim and other diaminopyrimidine dihydrofolate reductase inhibitors with omega-carboxyalkoxy or omega-carboxy-1-alkynyl substitution in the side chain.
Chan DC; Fu H; Forsch RA; Queener SF; Rosowsky A
J Med Chem; 2005 Jun; 48(13):4420-31. PubMed ID: 15974594
[TBL] [Abstract][Full Text] [Related]
17. Synthesis and biological evaluation of biguanide and dihydrotriazine derivatives as potential inhibitors of dihydrofolate reductase of opportunistic microorganisms.
Bag S; Tawari NR; Queener SF; Degani MS
J Enzyme Inhib Med Chem; 2010 Jun; 25(3):331-9. PubMed ID: 19874136
[TBL] [Abstract][Full Text] [Related]
18. Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid and N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid as dual inhibitors of dihydrofolate reductase and thymidylate synthase and as potential antitumor agents.
Gangjee A; Lin X; Kisliuk RL; McGuire JJ
J Med Chem; 2005 Nov; 48(23):7215-22. PubMed ID: 16279780
[TBL] [Abstract][Full Text] [Related]
19. Nonclassical 2,4-diamino-8-deazafolate analogues as inhibitors of dihydrofolate reductases from rat liver, Pneumocystis carinii, and Toxoplasma gondii.
Gangjee A; Zhu Y; Queener SF; Francom P; Broom AD
J Med Chem; 1996 Apr; 39(9):1836-45. PubMed ID: 8627607
[TBL] [Abstract][Full Text] [Related]
20. Preliminary in vitro studies on two potent, water-soluble trimethoprim analogues with exceptional species selectivity against dihydrofolate reductase from Pneumocystis carinii and Mycobacterium avium.
Forsch RA; Queener SF; Rosowsky A
Bioorg Med Chem Lett; 2004 Apr; 14(7):1811-5. PubMed ID: 15026078
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]