BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

283 related articles for article (PubMed ID: 17576665)

  • 1. Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1.
    Antony S; Marchand C; Stephen AG; Thibaut L; Agama KK; Fisher RJ; Pommier Y
    Nucleic Acids Res; 2007; 35(13):4474-84. PubMed ID: 17576665
    [TBL] [Abstract][Full Text] [Related]  

  • 2. 4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesulfonate) (NSC 88915) and related novel steroid derivatives as tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors.
    Dexheimer TS; Gediya LK; Stephen AG; Weidlich I; Antony S; Marchand C; Interthal H; Nicklaus M; Fisher RJ; Njar VC; Pommier Y
    J Med Chem; 2009 Nov; 52(22):7122-31. PubMed ID: 19883083
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Inhibition of human tyrosyl-DNA phosphodiesterase by aminoglycoside antibiotics and ribosome inhibitors.
    Liao Z; Thibaut L; Jobson A; Pommier Y
    Mol Pharmacol; 2006 Jul; 70(1):366-72. PubMed ID: 16618796
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay.
    Marchand C; Lea WA; Jadhav A; Dexheimer TS; Austin CP; Inglese J; Pommier Y; Simeonov A
    Mol Cancer Ther; 2009 Jan; 8(1):240-8. PubMed ID: 19139134
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Insights into substrate binding and catalytic mechanism of human tyrosyl-DNA phosphodiesterase (Tdp1) from vanadate and tungstate-inhibited structures.
    Davies DR; Interthal H; Champoux JJ; Hol WG
    J Mol Biol; 2002 Dec; 324(5):917-32. PubMed ID: 12470949
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Pre-steady state kinetics of DNA binding and abasic site hydrolysis by tyrosyl-DNA phosphodiesterase 1.
    Kuznetsov NA; Lebedeva NA; Kuznetsova AA; Rechkunova NI; Dyrkheeva NS; Kupryushkin MS; Stetsenko DA; Pyshnyi DV; Fedorova OS; Lavrik OI
    J Biomol Struct Dyn; 2017 Aug; 35(11):2314-2327. PubMed ID: 27687298
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitors.
    Huang SN; Pommier Y; Marchand C
    Expert Opin Ther Pat; 2011 Sep; 21(9):1285-92. PubMed ID: 21843105
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and evaluation of aryliden- and hetarylidenfuranone derivatives of usnic acid as highly potent Tdp1 inhibitors.
    Zakharova O; Luzina O; Zakharenko A; Sokolov D; Filimonov A; Dyrkheeva N; Chepanova A; Ilina E; Ilyina A; Klabenkova K; Chelobanov B; Stetsenko D; Zafar A; Eurtivong C; Reynisson J; Volcho K; Salakhutdinov N; Lavrik O
    Bioorg Med Chem; 2018 Aug; 26(15):4470-4480. PubMed ID: 30076000
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis, anti-cancer screening and tyrosyl-DNA phosphodiesterase 1 (Tdp1) inhibition activity of novel piperidinyl sulfamides.
    Jun JH; Kumar V; Dexheimer TS; Wedlich I; Nicklaus MC; Pommier Y; Malhotra SV
    Eur J Pharm Sci; 2018 Jan; 111():337-348. PubMed ID: 29037996
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2
    Li-Zhulanov NS; Zakharenko AL; Chepanova AA; Patel J; Zafar A; Volcho KP; Salakhutdinov NF; Reynisson J; Leung IKH; Lavrik OI
    Molecules; 2018 Sep; 23(10):. PubMed ID: 30261631
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Tyrosyl-DNA phosphodiesterase as a target for anticancer therapy.
    Dexheimer TS; Antony S; Marchand C; Pommier Y
    Anticancer Agents Med Chem; 2008 May; 8(4):381-9. PubMed ID: 18473723
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Identification of a putative Tdp1 inhibitor (CD00509) by in vitro and cell-based assays.
    Dean RA; Fam HK; An J; Choi K; Shimizu Y; Jones SJ; Boerkoel CF; Interthal H; Pfeifer TA
    J Biomol Screen; 2014 Dec; 19(10):1372-82. PubMed ID: 25117203
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors.
    Walker S; Meisenberg C; Bibby RA; Askwith T; Williams G; Rininsland FH; Pearl LH; Oliver AW; El-Khamisy S; Ward S; Atack JR
    Anal Biochem; 2014 Jun; 454(100):17-22. PubMed ID: 24637157
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Dual DNA topoisomerase 1 and tyrosyl-DNA phosphodiesterase 1 inhibition for improved anticancer activity.
    Zakharenko A; Dyrkheeva N; Lavrik O
    Med Res Rev; 2019 Jul; 39(4):1427-1441. PubMed ID: 31004352
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Tyrosyl-DNA phosphodiesterase (Tdp1) (3'-phosphotyrosyl DNA phosphodiesterase).
    Raymond AC; Burgin AB
    Methods Enzymol; 2006; 409():511-24. PubMed ID: 16793421
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis of Methoxy-, Methylenedioxy-, Hydroxy-, and Halo-Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors and Their Biological Activity for Drug-Resistant Cancer.
    Hu DX; Tang WL; Zhang Y; Yang H; Wang W; Agama K; Pommier Y; An LK
    J Med Chem; 2021 Jun; 64(11):7617-7629. PubMed ID: 34008967
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis and biological evaluation of novel tyrosyl-DNA phosphodiesterase 1 inhibitors with a benzopentathiepine moiety.
    Zakharenko A; Khomenko T; Zhukova S; Koval O; Zakharova O; Anarbaev R; Lebedeva N; Korchagina D; Komarova N; Vasiliev V; Reynisson J; Volcho K; Salakhutdinov N; Lavrik O
    Bioorg Med Chem; 2015 May; 23(9):2044-52. PubMed ID: 25819333
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents.
    Zhang XR; Wang HW; Tang WL; Zhang Y; Yang H; Hu DX; Ravji A; Marchand C; Kiselev E; Ofori-Atta K; Agama K; Pommier Y; An LK
    J Med Chem; 2018 Nov; 61(22):9908-9930. PubMed ID: 30336023
    [TBL] [Abstract][Full Text] [Related]  

  • 19. 5-Arylidenethioxothiazolidinones as inhibitors of tyrosyl-DNA phosphodiesterase I.
    Sirivolu VR; Vernekar SK; Marchand C; Naumova A; Chergui A; Renaud A; Stephen AG; Chen F; Sham YY; Pommier Y; Wang Z
    J Med Chem; 2012 Oct; 55(20):8671-84. PubMed ID: 23006064
    [TBL] [Abstract][Full Text] [Related]  

  • 20. New 5-Hydroxycoumarin-Based Tyrosyl-DNA Phosphodiesterase I Inhibitors Sensitize Tumor Cell Line to Topotecan.
    Khomenko TM; Zakharenko AL; Kornienko TE; Chepanova AA; Dyrkheeva NS; Artemova AO; Korchagina DV; Achara C; Curtis A; Reynisson J; Volcho KP; Salakhutdinov NF; Lavrik OI
    Int J Mol Sci; 2023 May; 24(11):. PubMed ID: 37298106
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.