BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

251 related articles for article (PubMed ID: 17576677)

  • 1. Following an environmental carcinogen N2-dG adduct through replication: elucidating blockage and bypass in a high-fidelity DNA polymerase.
    Xu P; Oum L; Beese LS; Geacintov NE; Broyde S
    Nucleic Acids Res; 2007; 35(13):4275-88. PubMed ID: 17576677
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Visualizing sequence-governed nucleotide selectivities and mutagenic consequences through a replicative cycle: processing of a bulky carcinogen N2-dG lesion in a Y-family DNA polymerase.
    Xu P; Oum L; Lee YC; Geacintov NE; Broyde S
    Biochemistry; 2009 Jun; 48(22):4677-90. PubMed ID: 19364137
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Extending the understanding of mutagenicity: structural insights into primer-extension past a benzo[a]pyrene diol epoxide-DNA adduct.
    Perlow RA; Broyde S
    J Mol Biol; 2003 Apr; 327(4):797-818. PubMed ID: 12654264
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The spacious active site of a Y-family DNA polymerase facilitates promiscuous nucleotide incorporation opposite a bulky carcinogen-DNA adduct: elucidating the structure-function relationship through experimental and computational approaches.
    Perlow-Poehnelt RA; Likhterov I; Scicchitano DA; Geacintov NE; Broyde S
    J Biol Chem; 2004 Aug; 279(35):36951-61. PubMed ID: 15210693
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Toward understanding the mutagenicity of an environmental carcinogen: structural insights into nucleotide incorporation preferences.
    Perlow RA; Broyde S
    J Mol Biol; 2002 Sep; 322(2):291-309. PubMed ID: 12217692
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structure and mechanism of error-free replication past the major benzo[a]pyrene adduct by human DNA polymerase κ.
    Jha V; Bian C; Xing G; Ling H
    Nucleic Acids Res; 2016 Jun; 44(10):4957-67. PubMed ID: 27034468
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Mutagenic nucleotide incorporation and hindered translocation by a food carcinogen C8-dG adduct in Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4): modeling and dynamics studies.
    Zhang L; Rechkoblit O; Wang L; Patel DJ; Shapiro R; Broyde S
    Nucleic Acids Res; 2006; 34(11):3326-37. PubMed ID: 16820532
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Solution conformation of the (-)-cis-anti-benzo[a]pyrenyl-dG adduct opposite dC in a DNA duplex: intercalation of the covalently attached BP ring into the helix with base displacement of the modified deoxyguanosine into the major groove.
    Cosman M; Hingerty BE; Luneva N; Amin S; Geacintov NE; Broyde S; Patel DJ
    Biochemistry; 1996 Jul; 35(30):9850-63. PubMed ID: 8703959
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Evading the proofreading machinery of a replicative DNA polymerase: induction of a mutation by an environmental carcinogen.
    Perlow RA; Broyde S
    J Mol Biol; 2001 Jun; 309(2):519-36. PubMed ID: 11371169
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Solution conformation of the (-)-trans-anti-[BP]dG adduct opposite a deletion site in a DNA duplex: intercalation of the covalently attached benzo[a]pyrene into the helix with base displacement of the modified deoxyguanosine into the minor groove.
    Feng B; Gorin A; Kolbanovskiy A; Hingerty BE; Geacintov NE; Broyde S; Patel DJ
    Biochemistry; 1997 Nov; 36(45):13780-90. PubMed ID: 9374854
    [TBL] [Abstract][Full Text] [Related]  

  • 11. How Y-Family DNA polymerase IV is more accurate than Dpo4 at dCTP insertion opposite an N2-dG adduct of benzo[a]pyrene.
    Sholder G; Creech A; Loechler EL
    DNA Repair (Amst); 2015 Nov; 35():144-53. PubMed ID: 26523515
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A structural gap in Dpo4 supports mutagenic bypass of a major benzo[a]pyrene dG adduct in DNA through template misalignment.
    Bauer J; Xing G; Yagi H; Sayer JM; Jerina DM; Ling H
    Proc Natl Acad Sci U S A; 2007 Sep; 104(38):14905-10. PubMed ID: 17848527
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Y-Family DNA polymerases may use two different dNTP shapes for insertion: a hypothesis and its implications.
    Chandani S; Loechler EL
    J Mol Graph Model; 2009 Apr; 27(7):759-69. PubMed ID: 19188081
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Solution conformation of the (+)-cis-anti-[BP]dG adduct opposite a deletion site in a DNA duplex: intercalation of the covalently attached benzo[a]pyrene into the helix with base displacement of the modified deoxyguanosine into the minor groove.
    Cosman M; Fiala R; Hingerty BE; Amin S; Geacintov NE; Broyde S; Patel DJ
    Biochemistry; 1994 Sep; 33(38):11518-27. PubMed ID: 7918365
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Stereochemical origin of opposite orientations in DNA adducts derived from enantiomeric anti-benzo[a]pyrene diol epoxides with different tumorigenic potentials.
    Xie XM; Geacintov NE; Broyde S
    Biochemistry; 1999 Mar; 38(10):2956-68. PubMed ID: 10074348
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structural alignment of the (+)-trans-anti-benzo[a]pyrene-dG adduct positioned opposite dC at a DNA template-primer junction.
    Feng B; Gorin A; Hingerty BE; Geacintov NE; Broyde S; Patel DJ
    Biochemistry; 1997 Nov; 36(45):13769-79. PubMed ID: 9374853
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Molecular modeling benzo[a]pyrene N2-dG adducts in the two overlapping active sites of the Y-family DNA polymerase Dpo4.
    Chandani S; Loechler EL
    J Mol Graph Model; 2007 Jan; 25(5):658-70. PubMed ID: 16782374
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The N-clasp of human DNA polymerase kappa promotes blockage or error-free bypass of adenine- or guanine-benzo[a]pyrenyl lesions.
    Jia L; Geacintov NE; Broyde S
    Nucleic Acids Res; 2008 Nov; 36(20):6571-84. PubMed ID: 18931375
    [TBL] [Abstract][Full Text] [Related]  

  • 19. In vitro bypass of malondialdehyde-deoxyguanosine adducts: differential base selection during extension by the Klenow fragment of DNA polymerase I is the critical determinant of replication outcome.
    Hashim MF; Riggins JN; Schnetz-Boutaud N; Voehler M; Stone MP; Marnett LJ
    Biochemistry; 2004 Sep; 43(37):11828-35. PubMed ID: 15362868
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Altering DNA polymerase incorporation fidelity by distorting the dNTP binding pocket with a bulky carcinogen-damaged template.
    Yan SF; Wu M; Geacintov NE; Broyde S
    Biochemistry; 2004 Jun; 43(24):7750-65. PubMed ID: 15196018
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.