80 related articles for article (PubMed ID: 17582777)
1. Analysis of alteration of p75NTR processing and signalling by PS2 mutation and gamma-secretase inhibition.
Ito Y; Ishii A; Passmore AP; McIlroy SP
Neurobiol Dis; 2007 Sep; 27(3):258-64. PubMed ID: 17582777
[TBL] [Abstract][Full Text] [Related]
2. Familial Alzheimer's disease presenilin 1 mutation M146V increases gamma secretase cutting of p75NTR in vitro.
Hatchett CS; Tyler S; Armstrong D; Dawbarn D; Allen SJ
Brain Res; 2007 May; 1147():248-55. PubMed ID: 17349981
[TBL] [Abstract][Full Text] [Related]
3. Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity.
Sevalle J; Ayral E; Hernandez JF; Martinez J; Checler F
J Neurochem; 2009 Jul; 110(1):275-83. PubMed ID: 19457123
[TBL] [Abstract][Full Text] [Related]
4. Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes.
Shirotani K; Tomioka M; Kremmer E; Haass C; Steiner H
Neurobiol Dis; 2007 Jul; 27(1):102-7. PubMed ID: 17560791
[TBL] [Abstract][Full Text] [Related]
5. Involvement of presenilins in cell-survival signalling pathways.
McCarthy JV
Biochem Soc Trans; 2005 Aug; 33(Pt 4):568-72. PubMed ID: 16042546
[TBL] [Abstract][Full Text] [Related]
6. An alternative spliced mouse presenilin-2 mRNA encodes a novel gamma-secretase inhibitor.
Suzuki Y; Ohta K; Itoh M; Sakoh-Sumitomo Y; Mitsuda T; Ueda M; Hayakawa-Yano Y; Li S; Hida Y; Inuzuka T; Jung YK; Nakagawa T
FEBS Lett; 2009 May; 583(9):1403-8. PubMed ID: 19376115
[TBL] [Abstract][Full Text] [Related]
7. Protease digestion indicates that endogenous presenilin 1 is present in at least two physical forms.
Oh YS; Turner RJ
Biochem Biophys Res Commun; 2006 Jul; 346(1):330-4. PubMed ID: 16756946
[TBL] [Abstract][Full Text] [Related]
8. Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human gamma-secretase.
Winkler E; Hobson S; Fukumori A; Dümpelfeld B; Luebbers T; Baumann K; Haass C; Hopf C; Steiner H
Biochemistry; 2009 Feb; 48(6):1183-97. PubMed ID: 19159235
[TBL] [Abstract][Full Text] [Related]
9. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
Martone RL; Zhou H; Atchison K; Comery T; Xu JZ; Huang X; Gong X; Jin M; Kreft A; Harrison B; Mayer SC; Aschmies S; Gonzales C; Zaleska MM; Riddell DR; Wagner E; Lu P; Sun SC; Sonnenberg-Reines J; Oganesian A; Adkins K; Leach MW; Clarke DW; Huryn D; Abou-Gharbia M; Magolda R; Bard J; Frick G; Raje S; Forlow SB; Balliet C; Burczynski ME; Reinhart PH; Wan HI; Pangalos MN; Jacobsen JS
J Pharmacol Exp Ther; 2009 Nov; 331(2):598-608. PubMed ID: 19671883
[TBL] [Abstract][Full Text] [Related]
10. Generation of intracellular domain of insulin receptor tyrosine kinase by gamma-secretase.
Kasuga K; Kaneko H; Nishizawa M; Onodera O; Ikeuchi T
Biochem Biophys Res Commun; 2007 Aug; 360(1):90-6. PubMed ID: 17577576
[TBL] [Abstract][Full Text] [Related]
11. Inhibition of gamma-secretase activity reduces Abeta production, reduces oxidative stress, increases mitochondrial activity and leads to reduced vulnerability to apoptosis: Implications for the treatment of Alzheimer's disease.
Sheng B; Gong K; Niu Y; Liu L; Yan Y; Lu G; Zhang L; Hu M; Zhao N; Zhang X; Tang P; Gong Y
Free Radic Biol Med; 2009 May; 46(10):1362-75. PubMed ID: 19264123
[TBL] [Abstract][Full Text] [Related]
12. Metalloproteases and gamma-secretase: new membrane partners regulating p75 neurotrophin receptor signaling?
Bronfman FC
J Neurochem; 2007 Nov; 103 Suppl 1():91-100. PubMed ID: 17986144
[TBL] [Abstract][Full Text] [Related]
13. CD40/CD40L interaction induces Abeta production and increases gamma-secretase activity independently of tumor necrosis factor receptor associated factor (TRAF) signaling.
Volmar CH; Ait-Ghezala G; Frieling J; Weeks OI; Mullan MJ
Exp Cell Res; 2009 Aug; 315(13):2265-74. PubMed ID: 19422822
[TBL] [Abstract][Full Text] [Related]
14. The Alzheimer's disease-associated gamma-secretase complex: functional domains in the presenilin 1 protein.
Laudon H; Winblad B; Näslund J
Physiol Behav; 2007 Sep; 92(1-2):115-20. PubMed ID: 17588625
[TBL] [Abstract][Full Text] [Related]
15. Differential role of Presenilin-1 and -2 on mitochondrial membrane potential and oxygen consumption in mouse embryonic fibroblasts.
Behbahani H; Shabalina IG; Wiehager B; Concha H; Hultenby K; Petrovic N; Nedergaard J; Winblad B; Cowburn RF; Ankarcrona M
J Neurosci Res; 2006 Sep; 84(4):891-902. PubMed ID: 16883555
[TBL] [Abstract][Full Text] [Related]
16. Processes of beta-amyloid and intracellular cytoplasmic domain generation by presenilin/gamma-secretase.
Tagami S; Okochi M; Fukumori A; Jiang J; Yanagida K; Nakayama T; Morihara T; Tanaka T; Kudo T; Takeda M
Neurodegener Dis; 2008; 5(3-4):160-2. PubMed ID: 18322378
[TBL] [Abstract][Full Text] [Related]
17. Rac1 changes the substrate specificity of gamma-secretase between amyloid precursor protein and Notch1.
Boo JH; Sohn JH; Kim JE; Song H; Mook-Jung I
Biochem Biophys Res Commun; 2008 Aug; 372(4):913-7. PubMed ID: 18538664
[TBL] [Abstract][Full Text] [Related]
18. Presenilin regulates extracellular regulated kinase (Erk) activity by a protein kinase C alpha dependent mechanism.
Dehvari N; Isacsson O; Winblad B; Cedazo-Minguez A; Cowburn RF
Neurosci Lett; 2008 May; 436(1):77-80. PubMed ID: 18367332
[TBL] [Abstract][Full Text] [Related]
19. Sodium selenite inhibits gamma-secretase activity through activation of ERK.
Tung YT; Hsu WM; Wang BJ; Wu SY; Yen CT; Hu MK; Liao YF
Neurosci Lett; 2008 Jul; 440(1):38-43. PubMed ID: 18547722
[TBL] [Abstract][Full Text] [Related]
20. Presenilin diversifies its portfolio.
Parks AL; Curtis D
Trends Genet; 2007 Mar; 23(3):140-50. PubMed ID: 17280736
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]