BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

91 related articles for article (PubMed ID: 17587573)

  • 21. 4-(3-aryloxyaryl)quinoline alcohols are liver X receptor agonists.
    Bernotas RC; Kaufman DH; Singhaus RR; Ullrich J; Unwalla R; Quinet E; Nambi P; Wilhelmsson A; Goos-Nilsson A; Wrobel J
    Bioorg Med Chem; 2009 Dec; 17(23):8086-92. PubMed ID: 19853462
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Physiological differences between human and rat primary hepatocytes in response to liver X receptor activation by 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride (GW3965).
    Kotokorpi P; Ellis E; Parini P; Nilsson LM; Strom S; Steffensen KR; Gustafsson JA; Mode A
    Mol Pharmacol; 2007 Oct; 72(4):947-55. PubMed ID: 17628011
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Therapeutic opportunities for liver X receptor modulators.
    Collins JL
    Curr Opin Drug Discov Devel; 2004 Sep; 7(5):692-702. PubMed ID: 15503871
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Further modification on phenyl acetic acid based quinolines as liver X receptor modulators.
    Hu B; Jetter J; Kaufman D; Singhaus R; Bernotas R; Unwalla R; Quinet E; Savio D; Halpern A; Basso M; Keith J; Clerin V; Chen L; Liu QY; Feingold I; Huselton C; Azam F; Goos-Nilsson A; Wilhelmsson A; Nambi P; Wrobel J
    Bioorg Med Chem; 2007 May; 15(10):3321-33. PubMed ID: 17391964
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory element-binding protein-1c.
    Hegarty BD; Bobard A; Hainault I; Ferré P; Bossard P; Foufelle F
    Proc Natl Acad Sci U S A; 2005 Jan; 102(3):791-6. PubMed ID: 15637161
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity.
    Chao EY; Caravella JA; Watson MA; Campobasso N; Ghisletti S; Billin AN; Galardi C; Wang P; Laffitte BA; Iannone MA; Goodwin BJ; Nichols JA; Parks DJ; Stewart E; Wiethe RW; Williams SP; Smallwood A; Pearce KH; Glass CK; Willson TM; Zuercher WJ; Collins JL
    J Med Chem; 2008 Sep; 51(18):5758-65. PubMed ID: 18800767
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Lesion macrophages are a key target for the antiatherogenic effects of LXR agonists.
    Bradley MN; Tontonoz P
    Arterioscler Thromb Vasc Biol; 2005 Jan; 25(1):10-1. PubMed ID: 15626767
    [No Abstract]   [Full Text] [Related]  

  • 28. Synthesis of 4-(3-biaryl)quinoline sulfones as potent liver X receptor agonists.
    Ullrich JW; Morris R; Bernotas RC; Travins JM; Jetter J; Unwalla R; Quinet E; Nambi P; Feingold I; Huselton C; Enroth C; Wilhelmsson A; Goos-Nilsson A; Wrobel J
    Bioorg Med Chem Lett; 2010 May; 20(9):2903-7. PubMed ID: 20382019
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR.
    Ou J; Tu H; Shan B; Luk A; DeBose-Boyd RA; Bashmakov Y; Goldstein JL; Brown MS
    Proc Natl Acad Sci U S A; 2001 May; 98(11):6027-32. PubMed ID: 11371634
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice.
    Chen W; Chen G; Head DL; Mangelsdorf DJ; Russell DW
    Cell Metab; 2007 Jan; 5(1):73-9. PubMed ID: 17189208
    [TBL] [Abstract][Full Text] [Related]  

  • 31. A novel liver X receptor agonist establishes species differences in the regulation of cholesterol 7alpha-hydroxylase (CYP7a).
    Menke JG; Macnaul KL; Hayes NS; Baffic J; Chao YS; Elbrecht A; Kelly LJ; Lam MH; Schmidt A; Sahoo S; Wang J; Wright SD; Xin P; Zhou G; Moller DE; Sparrow CP
    Endocrinology; 2002 Jul; 143(7):2548-58. PubMed ID: 12072387
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Combating atherosclerosis with LXR alpha and PPAR alpha agonists: is rational multitargeted polypharmacy the future of therapeutics in complex diseases?
    Kino T; Chrousos GP
    Mol Interv; 2004 Oct; 4(5):254-7. PubMed ID: 15471908
    [No Abstract]   [Full Text] [Related]  

  • 33. The nuclear receptor LXR is a glucose sensor.
    Mitro N; Mak PA; Vargas L; Godio C; Hampton E; Molteni V; Kreusch A; Saez E
    Nature; 2007 Jan; 445(7124):219-23. PubMed ID: 17187055
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Discovery and optimization of a novel series of liver X receptor-alpha agonists.
    Li L; Liu J; Zhu L; Cutler S; Hasegawa H; Shan B; Medina JC
    Bioorg Med Chem Lett; 2006 Mar; 16(6):1638-42. PubMed ID: 16386417
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Nuclear localization of liver X receptor alpha and beta is differentially regulated.
    Prüfer K; Boudreaux J
    J Cell Biochem; 2007 Jan; 100(1):69-85. PubMed ID: 16888799
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Identification of small molecule agonists of the orphan nuclear receptors liver receptor homolog-1 and steroidogenic factor-1.
    Whitby RJ; Dixon S; Maloney PR; Delerive P; Goodwin BJ; Parks DJ; Willson TM
    J Med Chem; 2006 Nov; 49(23):6652-5. PubMed ID: 17154495
    [TBL] [Abstract][Full Text] [Related]  

  • 37. [Role of LXRs in control of lipogenesis].
    Kugimiya A; Takagi J; Uesugi M
    Tanpakushitsu Kakusan Koso; 2007 Oct; 52(13 Suppl):1814-5. PubMed ID: 18051439
    [No Abstract]   [Full Text] [Related]  

  • 38. Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources.
    Jayasuriya H; Herath KB; Ondeyka JG; Guan Z; Borris RP; Tiwari S; de Jong W; Chavez F; Moss J; Stevenson DW; Beck HT; Slattery M; Zamora N; Schulman M; Ali A; Sharma N; MacNaul K; Hayes N; Menke JG; Singh SB
    J Nat Prod; 2005 Aug; 68(8):1247-52. PubMed ID: 16124770
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Discovery of aryl-substituted indole and indoline derivatives as RORγt agonists.
    Zhu Y; Sun N; Yu M; Guo H; Xie Q; Wang Y
    Eur J Med Chem; 2019 Nov; 182():111589. PubMed ID: 31425906
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Conversion of the LXR-agonist TO-901317--from inverse to normal modulation of gamma-secretase by addition of a carboxylic acid and a lipophilic anchor.
    Narlawar R; Baumann K; Czech C; Schmidt B
    Bioorg Med Chem Lett; 2007 Oct; 17(19):5428-31. PubMed ID: 17723298
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 5.