BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

289 related articles for article (PubMed ID: 17604271)

  • 1. PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex.
    Fonseca BD; Smith EM; Lee VH; MacKintosh C; Proud CG
    J Biol Chem; 2007 Aug; 282(34):24514-24. PubMed ID: 17604271
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1.
    Oshiro N; Takahashi R; Yoshino K; Tanimura K; Nakashima A; Eguchi S; Miyamoto T; Hara K; Takehana K; Avruch J; Kikkawa U; Yonezawa K
    J Biol Chem; 2007 Jul; 282(28):20329-39. PubMed ID: 17517883
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The mechanism of insulin-stimulated 4E-BP protein binding to mammalian target of rapamycin (mTOR) complex 1 and its contribution to mTOR complex 1 signaling.
    Rapley J; Oshiro N; Ortiz-Vega S; Avruch J
    J Biol Chem; 2011 Nov; 286(44):38043-38053. PubMed ID: 21914810
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Hydrogen peroxide impairs insulin-stimulated assembly of mTORC1.
    Zhang L; Kimball SR; Jefferson LS; Shenberger JS
    Free Radic Biol Med; 2009 Jun; 46(11):1500-9. PubMed ID: 19281842
    [TBL] [Abstract][Full Text] [Related]  

  • 5. RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells.
    Gordon BS; Kazi AA; Coleman CS; Dennis MD; Chau V; Jefferson LS; Kimball SR
    Cell Signal; 2014 Mar; 26(3):461-7. PubMed ID: 24316235
    [TBL] [Abstract][Full Text] [Related]  

  • 6. PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding.
    Wang L; Harris TE; Roth RA; Lawrence JC
    J Biol Chem; 2007 Jul; 282(27):20036-44. PubMed ID: 17510057
    [TBL] [Abstract][Full Text] [Related]  

  • 7. AKT inhibition overcomes rapamycin resistance by enhancing the repressive function of PRAS40 on mTORC1/4E-BP1 axis.
    Mi W; Ye Q; Liu S; She QB
    Oncotarget; 2015 Jun; 6(16):13962-77. PubMed ID: 25961827
    [TBL] [Abstract][Full Text] [Related]  

  • 8. PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis.
    Thedieck K; Polak P; Kim ML; Molle KD; Cohen A; Jenö P; Arrieumerlou C; Hall MN
    PLoS One; 2007 Nov; 2(11):e1217. PubMed ID: 18030348
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation.
    Wang L; Harris TE; Lawrence JC
    J Biol Chem; 2008 Jun; 283(23):15619-27. PubMed ID: 18372248
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein.
    Sato T; Nakashima A; Guo L; Tamanoi F
    J Biol Chem; 2009 May; 284(19):12783-91. PubMed ID: 19299511
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Curcumin disrupts the Mammalian target of rapamycin-raptor complex.
    Beevers CS; Chen L; Liu L; Luo Y; Webster NJ; Huang S
    Cancer Res; 2009 Feb; 69(3):1000-8. PubMed ID: 19176385
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Receptor-recognized α₂-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells.
    Misra UK; Pizzo SV
    PLoS One; 2012; 7(12):e51735. PubMed ID: 23272152
    [TBL] [Abstract][Full Text] [Related]  

  • 13. PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.
    Sancak Y; Thoreen CC; Peterson TR; Lindquist RA; Kang SA; Spooner E; Carr SA; Sabatini DM
    Mol Cell; 2007 Mar; 25(6):903-15. PubMed ID: 17386266
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Rapamycin inhibits cytoskeleton reorganization and cell motility by suppressing RhoA expression and activity.
    Liu L; Luo Y; Chen L; Shen T; Xu B; Chen W; Zhou H; Han X; Huang S
    J Biol Chem; 2010 Dec; 285(49):38362-73. PubMed ID: 20937815
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Alcohol and PRAS40 knockdown decrease mTOR activity and protein synthesis via AMPK signaling and changes in mTORC1 interaction.
    Hong-Brown LQ; Brown CR; Kazi AA; Huber DS; Pruznak AM; Lang CH
    J Cell Biochem; 2010 Apr; 109(6):1172-84. PubMed ID: 20127721
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins.
    Wang X; Beugnet A; Murakami M; Yamanaka S; Proud CG
    Mol Cell Biol; 2005 Apr; 25(7):2558-72. PubMed ID: 15767663
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Target of rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1.
    Beugnet A; Wang X; Proud CG
    J Biol Chem; 2003 Oct; 278(42):40717-22. PubMed ID: 12912989
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth.
    Acosta-Jaquez HA; Keller JA; Foster KG; Ekim B; Soliman GA; Feener EP; Ballif BA; Fingar DC
    Mol Cell Biol; 2009 Aug; 29(15):4308-24. PubMed ID: 19487463
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Identification of a conserved motif required for mTOR signaling.
    Schalm SS; Blenis J
    Curr Biol; 2002 Apr; 12(8):632-9. PubMed ID: 11967149
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Characterization of the Rheb-mTOR signaling pathway in mammalian cells: constitutive active mutants of Rheb and mTOR.
    Sato T; Umetsu A; Tamanoi F
    Methods Enzymol; 2008; 438():307-20. PubMed ID: 18413257
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.