BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

105 related articles for article (PubMed ID: 17606371)

  • 1. N-(5-chloro-2-(hydroxymethyl)-N-alkyl-arylsulfonamides as gamma-secretase inhibitors.
    Parker MF; Barten DM; Bergstrom CP; Bronson JJ; Corsa JA; Deshpande MS; Felsenstein KM; Guss VL; Hansel SB; Johnson G; Keavy DJ; Lau WY; Mock J; Prasad CV; Polson CT; Sloan CP; Smith DW; Wallace OB; Wang HH; Williams A; Zheng M
    Bioorg Med Chem Lett; 2007 Aug; 17(16):4432-6. PubMed ID: 17606371
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Carbamate-appended N-alkylsulfonamides as inhibitors of gamma-secretase.
    Bergstrom CP; Sloan CP; Lau WY; Smith DW; Zheng M; Hansel SB; Polson CT; Corsa JA; Barten DM; Felsenstein KM; Roberts SB
    Bioorg Med Chem Lett; 2008 Jan; 18(2):464-8. PubMed ID: 18178084
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Nitrogen-appended N-alkylsulfonamides as inhibitors of gamma-secretase.
    Bergstrom CP; Sloan CP; Wang HH; Parker MF; Smith DW; Zheng M; Hansel SB; Polson CT; Barber LE; Bursuker I; Guss VL; Corsa JA; Barten DM; Felsenstein KM; Roberts SB
    Bioorg Med Chem Lett; 2008 Jan; 18(1):175-8. PubMed ID: 18023581
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis and structure-activity relationship of a novel series of heterocyclic sulfonamide gamma-secretase inhibitors.
    Pu J; Kreft AF; Aschmies SH; Atchison KP; Berkowitz J; Caggiano TJ; Chlenov M; Diamantidis G; Harrison BL; Hu Y; Huryn D; Steven Jacobsen J; Jin M; Lipinski K; Lu P; Martone RL; Morris K; Sonnenberg-Reines J; Riddell DR; Sabalski J; Sun SC; Wagner E; Wang Y; Xu Z; Zhou H; Resnick L
    Bioorg Med Chem; 2009 Jul; 17(13):4708-17. PubMed ID: 19443228
    [TBL] [Abstract][Full Text] [Related]  

  • 5. 2-(N-Benzyl-N-phenylsulfonamido)alkyl amide derivatives as γ-secretase inhibitors.
    Parker MF; Barten DM; Bergstrom CP; Bronson JJ; Corsa JA; Dee MF; Gai Y; Guss VL; Higgins MA; Keavy DJ; Loo A; Mate RA; Marcin LR; McElhone KE; Polson CT; Roberts SB; Macor JE
    Bioorg Med Chem Lett; 2012 Nov; 22(22):6828-31. PubMed ID: 23046960
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Ex vivo occupancy of gamma-secretase inhibitors correlates with brain beta-amyloid peptide reduction in Tg2576 mice.
    Goldstein ME; Cao Y; Fiedler T; Toyn J; Iben L; Barten DM; Pierdomenico M; Corsa J; Prasad CV; Olson RE; Li YW; Zaczek R; Albright CF
    J Pharmacol Exp Ther; 2007 Oct; 323(1):102-8. PubMed ID: 17640949
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Dynamics of Abeta turnover and deposition in different beta-amyloid precursor protein transgenic mouse models following gamma-secretase inhibition.
    Abramowski D; Wiederhold KH; Furrer U; Jaton AL; Neuenschwander A; Runser MJ; Danner S; Reichwald J; Ammaturo D; Staab D; Stoeckli M; Rueeger H; Neumann U; Staufenbiel M
    J Pharmacol Exp Ther; 2008 Nov; 327(2):411-24. PubMed ID: 18687920
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Tricyclic sulfones as orally active gamma-secretase inhibitors: synthesis and structure-activity relationship studies.
    Sasikumar TK; Qiang L; Burnett DA; Cole D; Xu R; Li H; Greenlee WJ; Clader J; Zhang L; Hyde L
    Bioorg Med Chem Lett; 2010 Jun; 20(12):3632-5. PubMed ID: 20493690
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Small conformationally restricted piperidine N-arylsulfonamides as orally active gamma-secretase inhibitors.
    Josien H; Bara T; Rajagopalan M; Asberom T; Clader JW; Favreau L; Greenlee WJ; Hyde LA; Nomeir AA; Parker EM; Pissarnitski DA; Song L; Wong GT; Zhang L; Zhang Q; Zhao Z
    Bioorg Med Chem Lett; 2007 Oct; 17(19):5330-5. PubMed ID: 17761417
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease.
    Mayer SC; Kreft AF; Harrison B; Abou-Gharbia M; Antane M; Aschmies S; Atchison K; Chlenov M; Cole DC; Comery T; Diamantidis G; Ellingboe J; Fan K; Galante R; Gonzales C; Ho DM; Hoke ME; Hu Y; Huryn D; Jain U; Jin M; Kremer K; Kubrak D; Lin M; Lu P; Magolda R; Martone R; Moore W; Oganesian A; Pangalos MN; Porte A; Reinhart P; Resnick L; Riddell DR; Sonnenberg-Reines J; Stock JR; Sun SC; Wagner E; Wang T; Woller K; Xu Z; Zaleska MM; Zeldis J; Zhang M; Zhou H; Jacobsen JS
    J Med Chem; 2008 Dec; 51(23):7348-51. PubMed ID: 19012391
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious gamma-secretase inhibitors.
    Ye XM; Konradi AW; Smith J; Xu YZ; Dressen D; Garofalo AW; Marugg J; Sham HL; Truong AP; Jagodzinski J; Pleiss M; Zhang H; Goldbach E; Sauer JM; Brigham E; Bova M; Basi GS
    Bioorg Med Chem Lett; 2010 Apr; 20(7):2195-9. PubMed ID: 20207136
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Cyclic sulfamide gamma-secretase inhibitors.
    Sparey T; Beher D; Best J; Biba M; Castro JL; Clarke E; Hannam J; Harrison T; Lewis H; Madin A; Shearman M; Sohal B; Tsou N; Welch C; Wrigley J
    Bioorg Med Chem Lett; 2005 Oct; 15(19):4212-6. PubMed ID: 16054361
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity.
    Sevalle J; Ayral E; Hernandez JF; Martinez J; Checler F
    J Neurochem; 2009 Jul; 110(1):275-83. PubMed ID: 19457123
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Differential effects of gamma-secretase and BACE1 inhibition on brain Abeta levels in vitro and in vivo.
    Elvang AB; Volbracht C; Pedersen LØ; Jensen KG; Karlsson JJ; Larsen SA; Mørk A; Stensbøl TB; Bastlund JF
    J Neurochem; 2009 Sep; 110(5):1377-87. PubMed ID: 19519664
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Amino-caprolactam derivatives as gamma-secretase inhibitors.
    Parker MF; Bronson JJ; Barten DM; Corsa JA; Du W; Felsenstein KM; Guss VL; Izzarelli D; Loo A; McElhone KE; Marcin LR; Padmanabha R; Pak R; Polson CT; Toyn JH; Varma S; Wang J; Wong V; Zheng M; Roberts SB
    Bioorg Med Chem Lett; 2007 Nov; 17(21):5790-5. PubMed ID: 17869509
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Discovery of gamma-secretase inhibitors efficacious in a transgenic animal model of Alzheimer's disease.
    Asberom T; Zhao Z; Bara TA; Clader JW; Greenlee WJ; Hyde LA; Josien HB; Li W; McPhail AT; Nomeir AA; Parker EM; Rajagopalan M; Song L; Wong GT; Zhang L; Zhang Q; Pissarnitski DA
    Bioorg Med Chem Lett; 2007 Jan; 17(2):511-6. PubMed ID: 17079141
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Discovery of amide and heteroaryl isosteres as carbamate replacements in a series of orally active gamma-secretase inhibitors.
    McBriar MD; Clader JW; Chu I; Del Vecchio RA; Favreau L; Greenlee WJ; Hyde LA; Nomeir AA; Parker EM; Pissarnitski DA; Song L; Zhang L; Zhao Z
    Bioorg Med Chem Lett; 2008 Jan; 18(1):215-9. PubMed ID: 17988864
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Design, synthesis, and evaluation of tetrahydroquinoline and pyrrolidine sulfonamide carbamates as gamma-secretase inhibitors.
    Guo T; Gu H; Hobbs DW; Rokosz LL; Stauffer TM; Jacob B; Clader JW
    Bioorg Med Chem Lett; 2007 Jun; 17(11):3010-3. PubMed ID: 17418571
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands.
    Ghosh AK; Kumaragurubaran N; Hong L; Kulkarni SS; Xu X; Chang W; Weerasena V; Turner R; Koelsch G; Bilcer G; Tang J
    J Med Chem; 2007 May; 50(10):2399-407. PubMed ID: 17432843
    [TBL] [Abstract][Full Text] [Related]  

  • 20. In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.
    Sankaranarayanan S; Price EA; Wu G; Crouthamel MC; Shi XP; Tugusheva K; Tyler KX; Kahana J; Ellis J; Jin L; Steele T; Stachel S; Coburn C; Simon AJ
    J Pharmacol Exp Ther; 2008 Mar; 324(3):957-69. PubMed ID: 18156464
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.