BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

174 related articles for article (PubMed ID: 17631279)

  • 1. Mechanism of acridine-based telomerase inhibition and telomere shortening.
    Gunaratnam M; Greciano O; Martins C; Reszka AP; Schultes CM; Morjani H; Riou JF; Neidle S
    Biochem Pharmacol; 2007 Sep; 74(5):679-89. PubMed ID: 17631279
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function.
    Burger AM; Dai F; Schultes CM; Reszka AP; Moore MJ; Double JA; Neidle S
    Cancer Res; 2005 Feb; 65(4):1489-96. PubMed ID: 15735037
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Telomere targeting with a novel G-quadruplex-interactive ligand BRACO-19 induces T-loop disassembly and telomerase displacement in human glioblastoma cells.
    Zhou G; Liu X; Li Y; Xu S; Ma C; Wu X; Cheng Y; Yu Z; Zhao G; Chen Y
    Oncotarget; 2016 Mar; 7(12):14925-39. PubMed ID: 26908447
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Stabilization of Telomere G-Quadruplexes Interferes with Human Herpesvirus 6A Chromosomal Integration.
    Gilbert-Girard S; Gravel A; Artusi S; Richter SN; Wallaschek N; Kaufer BB; Flamand L
    J Virol; 2017 Jul; 91(14):. PubMed ID: 28468887
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Trisubstituted acridines as G-quadruplex telomere targeting agents. Effects of extensions of the 3,6- and 9-side chains on quadruplex binding, telomerase activity, and cell proliferation.
    Moore MJ; Schultes CM; Cuesta J; Cuenca F; Gunaratnam M; Tanious FA; Wilson WD; Neidle S
    J Med Chem; 2006 Jan; 49(2):582-99. PubMed ID: 16420044
    [TBL] [Abstract][Full Text] [Related]  

  • 6. BRACO19 analog dimers with improved inhibition of telomerase and hPot 1.
    Fu YT; Keppler BR; Soares J; Jarstfer MB
    Bioorg Med Chem; 2009 Mar; 17(5):2030-7. PubMed ID: 19201200
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Acquired cellular resistance to flavopiridol in a human colon carcinoma cell line involves up-regulation of the telomerase catalytic subunit and telomere elongation. Sensitivity of resistant cells to combination treatment with a telomerase inhibitor.
    Incles CM; Schultes CM; Kelland LR; Neidle S
    Mol Pharmacol; 2003 Nov; 64(5):1101-8. PubMed ID: 14573759
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and biological evaluation of novel 4,5-bis(dialkylaminoalkyl)-substituted acridines as potent telomeric G-quadruplex ligands.
    Laronze-Cochard M; Kim YM; Brassart B; Riou JF; Laronze JY; Sapi J
    Eur J Med Chem; 2009 Oct; 44(10):3880-8. PubMed ID: 19467742
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Pharmacodynamics of the G-quadruplex-stabilizing telomerase inhibitor 3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate (RHPS4) in vitro: activity in human tumor cells correlates with telomere length and can be enhanced, or antagonized, with cytotoxic agents.
    Cookson JC; Dai F; Smith V; Heald RA; Laughton CA; Stevens MF; Burger AM
    Mol Pharmacol; 2005 Dec; 68(6):1551-8. PubMed ID: 16150933
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism.
    Phatak P; Cookson JC; Dai F; Smith V; Gartenhaus RB; Stevens MF; Burger AM
    Br J Cancer; 2007 Apr; 96(8):1223-33. PubMed ID: 17406367
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Human telomerase inhibition by substituted acridine derivatives.
    Harrison RJ; Gowan SM; Kelland LR; Neidle S
    Bioorg Med Chem Lett; 1999 Sep; 9(17):2463-8. PubMed ID: 10498189
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A new steroid derivative stabilizes g-quadruplexes and induces telomere uncapping in human tumor cells.
    Brassart B; Gomez D; De Cian A; Paterski R; Montagnac A; Qui KH; Temime-Smaali N; Trentesaux C; Mergny JL; Gueritte F; Riou JF
    Mol Pharmacol; 2007 Sep; 72(3):631-40. PubMed ID: 17586599
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: the importance of G-quadruplex binding.
    Harrison RJ; Reszka AP; Haider SM; Romagnoli B; Morrell J; Read MA; Gowan SM; Incles CM; Kelland LR; Neidle S
    Bioorg Med Chem Lett; 2004 Dec; 14(23):5845-9. PubMed ID: 15501053
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Overcoming the immortality of tumour cells by telomere and telomerase based cancer therapeutics--current status and future prospects.
    Kelland LR
    Eur J Cancer; 2005 May; 41(7):971-9. PubMed ID: 15862745
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Rational design of acridine-based ligands with selectivity for human telomeric quadruplexes.
    Sparapani S; Haider SM; Doria F; Gunaratnam M; Neidle S
    J Am Chem Soc; 2010 Sep; 132(35):12263-72. PubMed ID: 20718414
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A G-quadruplex telomere targeting agent produces p16-associated senescence and chromosomal fusions in human prostate cancer cells.
    Incles CM; Schultes CM; Kempski H; Koehler H; Kelland LR; Neidle S
    Mol Cancer Ther; 2004 Oct; 3(10):1201-6. PubMed ID: 15486186
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity.
    Gowan SM; Harrison JR; Patterson L; Valenti M; Read MA; Neidle S; Kelland LR
    Mol Pharmacol; 2002 May; 61(5):1154-62. PubMed ID: 11961134
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Antitumor polycyclic acridines. 20. Search for DNA quadruplex binding selectivity in a series of 8,13-dimethylquino[4,3,2-kl]acridinium salts: telomere-targeted agents.
    Cheng MK; Modi C; Cookson JC; Hutchinson I; Heald RA; McCarroll AJ; Missailidis S; Tanious F; Wilson WD; Mergny JL; Laughton CA; Stevens MF
    J Med Chem; 2008 Feb; 51(4):963-75. PubMed ID: 18247546
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structure-based design of benzylamino-acridine compounds as G-quadruplex DNA telomere targeting agents.
    Martins C; Gunaratnam M; Stuart J; Makwana V; Greciano O; Reszka AP; Kelland LR; Neidle S
    Bioorg Med Chem Lett; 2007 Apr; 17(8):2293-8. PubMed ID: 17276687
    [TBL] [Abstract][Full Text] [Related]  

  • 20. G-quadruplex stabilizer 3,6-bis(1-methyl-4-vinylpyridinium)carbazole diiodide induces accelerated senescence and inhibits tumorigenic properties in cancer cells.
    Huang FC; Chang CC; Lou PJ; Kuo IC; Chien CW; Chen CT; Shieh FY; Chang TC; Lin JJ
    Mol Cancer Res; 2008 Jun; 6(6):955-64. PubMed ID: 18515756
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.