BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

178 related articles for article (PubMed ID: 17650504)

  • 1. The one-electron autoxidation of human cytochrome P450 3A4.
    Denisov IG; Grinkova YV; McLean MA; Sligar SG
    J Biol Chem; 2007 Sep; 282(37):26865-26873. PubMed ID: 17650504
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The ferrous-dioxygen intermediate in human cytochrome P450 3A4. Substrate dependence of formation and decay kinetics.
    Denisov IG; Grinkova YV; Baas BJ; Sligar SG
    J Biol Chem; 2006 Aug; 281(33):23313-8. PubMed ID: 16762915
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The thermodynamic landscape of testosterone binding to cytochrome P450 3A4: ligand binding and spin state equilibria.
    Roberts AG; Campbell AP; Atkins WM
    Biochemistry; 2005 Feb; 44(4):1353-66. PubMed ID: 15667229
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Cooperativity in cytochrome P450 3A4: linkages in substrate binding, spin state, uncoupling, and product formation.
    Denisov IG; Baas BJ; Grinkova YV; Sligar SG
    J Biol Chem; 2007 Mar; 282(10):7066-76. PubMed ID: 17213193
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Elucidation of distinct ligand binding sites for cytochrome P450 3A4.
    Hosea NA; Miller GP; Guengerich FP
    Biochemistry; 2000 May; 39(20):5929-39. PubMed ID: 10821664
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Lack of electron transfer from cytochrome b5 in stimulation of catalytic activities of cytochrome P450 3A4. Characterization of a reconstituted cytochrome P450 3A4/NADPH-cytochrome P450 reductase system and studies with apo-cytochrome b5.
    Yamazaki H; Johnson WW; Ueng YF; Shimada T; Guengerich FP
    J Biol Chem; 1996 Nov; 271(44):27438-44. PubMed ID: 8910324
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Allosteric mechanisms in cytochrome P450 3A4 studied by high-pressure spectroscopy: pivotal role of substrate-induced changes in the accessibility and degree of hydration of the heme pocket.
    Davydov DR; Baas BJ; Sligar SG; Halpert JR
    Biochemistry; 2007 Jul; 46(26):7852-64. PubMed ID: 17555301
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Coexpression of genetically engineered fused enzyme between yeast NADPH-P450 reductase and human cytochrome P450 3A4 and human cytochrome b5 in yeast.
    Hayashi K; Sakaki T; Kominami S; Inouye K; Yabusaki Y
    Arch Biochem Biophys; 2000 Sep; 381(1):164-70. PubMed ID: 11019832
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The use of isomeric testosterone dimers to explore allosteric effects in substrate binding to cytochrome P450 CYP3A4.
    Denisov IG; Mak PJ; Grinkova YV; Bastien D; Bérubé G; Sligar SG; Kincaid JR
    J Inorg Biochem; 2016 May; 158():77-85. PubMed ID: 26774838
    [TBL] [Abstract][Full Text] [Related]  

  • 10. N,N-diethyl-2-[4-(phenylmethyl)phenoxy] ethanamine (DPPE) a chemopotentiating and cytoprotective agent in clinical trials: interaction with histamine at cytochrome P450 3A4 and other isozymes that metabolize antineoplastic drugs.
    Brandes LJ; Queen GM; LaBella FS
    Cancer Chemother Pharmacol; 2000; 45(4):298-304. PubMed ID: 10755318
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Molecular characterization of specifically active recombinant fused enzymes consisting of CYP3A4, NADPH-cytochrome P450 oxidoreductase, and cytochrome b5.
    Inui H; Maeda A; Ohkawa H
    Biochemistry; 2007 Sep; 46(35):10213-21. PubMed ID: 17691855
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Kinetics of ferric cytochrome P450 reduction by NADPH-cytochrome P450 reductase: rapid reduction in the absence of substrate and variations among cytochrome P450 systems.
    Guengerich FP; Johnson WW
    Biochemistry; 1997 Dec; 36(48):14741-50. PubMed ID: 9398194
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Pyrene.pyrene complexes at the active site of cytochrome P450 3A4: evidence for a multiple substrate binding site.
    Dabrowski MJ; Schrag ML; Wienkers LC; Atkins WM
    J Am Chem Soc; 2002 Oct; 124(40):11866-7. PubMed ID: 12358527
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Roles of divalent metal ions in oxidations catalyzed by recombinant cytochrome P450 3A4 and replacement of NADPH--cytochrome P450 reductase with other flavoproteins, ferredoxin, and oxygen surrogates.
    Yamazaki H; Ueng YF; Shimada T; Guengerich FP
    Biochemistry; 1995 Jul; 34(26):8380-9. PubMed ID: 7599128
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Kinetics and thermodynamics of ligand binding by cytochrome P450 3A4.
    Isin EM; Guengerich FP
    J Biol Chem; 2006 Apr; 281(14):9127-36. PubMed ID: 16467307
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Sigmoidal kinetic model for two co-operative substrate-binding sites in a cytochrome P450 3A4 active site: an example of the metabolism of diazepam and its derivatives.
    Shou M; Mei Q; Ettore MW; Dai R; Baillie TA; Rushmore TH
    Biochem J; 1999 Jun; 340 ( Pt 3)(Pt 3):845-53. PubMed ID: 10359672
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Measurements of CO geminate recombination in cytochromes P450 and P420.
    Tian WD; Wells AV; Champion PM; Di Primo C; Gerber N; Sligar SG
    J Biol Chem; 1995 Apr; 270(15):8673-9. PubMed ID: 7721770
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Inhibition of human cytochrome P450 3A4 activity by zinc(II) ion.
    Kim JS; Yun CH
    Toxicol Lett; 2005 Apr; 156(3):341-50. PubMed ID: 15763633
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Electron shuttle between membrane-bound cytochrome P450 3A4 and b5 rules uncoupling mechanisms.
    Perret A; Pompon D
    Biochemistry; 1998 Aug; 37(33):11412-24. PubMed ID: 9708976
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Defining CYP3A4 structural responses to substrate binding. Raman spectroscopic studies of a nanodisc-incorporated mammalian cytochrome P450.
    Mak PJ; Denisov IG; Grinkova YV; Sligar SG; Kincaid JR
    J Am Chem Soc; 2011 Feb; 133(5):1357-66. PubMed ID: 21207936
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.