164 related articles for article (PubMed ID: 17657738)
1. The farnesyltransferase inhibitor R115777 (ZARNESTRA) enhances the pro-apoptotic activity of interferon-alpha through the inhibition of multiple survival pathways.
Caraglia M; Marra M; Viscomi C; D'Alessandro AM; Budillon A; Meo G; Arra C; Barbieri A; Rapp UR; Baldi A; Tassone P; Venuta S; Abbruzzese A; Tagliaferri P
Int J Cancer; 2007 Nov; 121(10):2317-30. PubMed ID: 17657738
[TBL] [Abstract][Full Text] [Related]
2. R115777 (Zarnestra)/Zoledronic acid (Zometa) cooperation on inhibition of prostate cancer proliferation is paralleled by Erk/Akt inactivation and reduced Bcl-2 and bad phosphorylation.
Caraglia M; Marra M; Leonetti C; Meo G; D'Alessandro AM; Baldi A; Santini D; Tonini G; Bertieri R; Zupi G; Budillon A; Abbruzzese A
J Cell Physiol; 2007 May; 211(2):533-43. PubMed ID: 17192846
[TBL] [Abstract][Full Text] [Related]
3. The farnesyl transferase inhibitor R115777 (Zarnestra) synergistically enhances growth inhibition and apoptosis induced on epidermoid cancer cells by Zoledronic acid (Zometa) and Pamidronate.
Caraglia M; D'Alessandro AM; Marra M; Giuberti G; Vitale G; Viscomi C; Colao A; Prete SD; Tagliaferri P; Tassone P; Budillon A; Venuta S; Abbruzzese A
Oncogene; 2004 Sep; 23(41):6900-13. PubMed ID: 15286715
[TBL] [Abstract][Full Text] [Related]
4. EGF activates an inducible survival response via the RAS-> Erk-1/2 pathway to counteract interferon-alpha-mediated apoptosis in epidermoid cancer cells.
Caraglia M; Tagliaferri P; Marra M; Giuberti G; Budillon A; Gennaro ED; Pepe S; Vitale G; Improta S; Tassone P; Venuta S; Bianco AR; Abbruzzese A
Cell Death Differ; 2003 Feb; 10(2):218-29. PubMed ID: 12700650
[TBL] [Abstract][Full Text] [Related]
5. C-Raf antagonizes apoptosis induced by IFN-alpha in human lung cancer cells by phosphorylation and increase of the intracellular content of elongation factor 1A.
Lamberti A; Longo O; Marra M; Tagliaferri P; Bismuto E; Fiengo A; Viscomi C; Budillon A; Rapp UR; Wang E; Venuta S; Abbruzzese A; Arcari P; Caraglia M
Cell Death Differ; 2007 May; 14(5):952-62. PubMed ID: 17332776
[TBL] [Abstract][Full Text] [Related]
6. Farnesyltransferase inhibitor R115777 inhibits cell growth and induces apoptosis in mantle cell lymphoma.
Rolland D; Camara-Clayette V; Barbarat A; Salles G; Coiffier B; Ribrag V; Thieblemont C
Cancer Chemother Pharmacol; 2008 Apr; 61(5):855-63. PubMed ID: 17639395
[TBL] [Abstract][Full Text] [Related]
7. Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro.
End DW; Smets G; Todd AV; Applegate TL; Fuery CJ; Angibaud P; Venet M; Sanz G; Poignet H; Skrzat S; Devine A; Wouters W; Bowden C
Cancer Res; 2001 Jan; 61(1):131-7. PubMed ID: 11196150
[TBL] [Abstract][Full Text] [Related]
8. R115777 induces Ras-independent apoptosis of myeloma cells via multiple intrinsic pathways.
Beaupre DM; Cepero E; Obeng EA; Boise LH; Lichtenheld MG
Mol Cancer Ther; 2004 Feb; 3(2):179-86. PubMed ID: 14985458
[TBL] [Abstract][Full Text] [Related]
9. Preclinical antitumor activity and pharmacodynamic studies with the farnesyl protein transferase inhibitor R115777 in human breast cancer.
Kelland LR; Smith V; Valenti M; Patterson L; Clarke PA; Detre S; End D; Howes AJ; Dowsett M; Workman P; Johnston SR
Clin Cancer Res; 2001 Nov; 7(11):3544-50. PubMed ID: 11705875
[TBL] [Abstract][Full Text] [Related]
10. Docetaxel induces p53-dependent apoptosis and synergizes with farnesyl transferase inhibitor r115777 in human epithelial cancer cells.
Caraglia M; Giuberti G; Marra M; Di Gennaro E; Facchini G; Caponigro F; Iaffaioli R; Budillon A; Abbruzzese A
Front Biosci; 2005 Sep; 10():2566-75. PubMed ID: 15970518
[TBL] [Abstract][Full Text] [Related]
11. The farnesyltransferase inhibitor R115777 reduces hypoxia and matrix metalloproteinase 2 expression in human glioma xenograft.
Delmas C; End D; Rochaix P; Favre G; Toulas C; Cohen-Jonathan E
Clin Cancer Res; 2003 Dec; 9(16 Pt 1):6062-8. PubMed ID: 14676133
[TBL] [Abstract][Full Text] [Related]
12. IFNalpha induces Fas expression and apoptosis in hedgehog pathway activated BCC cells through inhibiting Ras-Erk signaling.
Li C; Chi S; He N; Zhang X; Guicherit O; Wagner R; Tyring S; Xie J
Oncogene; 2004 Feb; 23(8):1608-17. PubMed ID: 14647422
[TBL] [Abstract][Full Text] [Related]
13. Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.
Lobell RB; Omer CA; Abrams MT; Bhimnathwala HG; Brucker MJ; Buser CA; Davide JP; deSolms SJ; Dinsmore CJ; Ellis-Hutchings MS; Kral AM; Liu D; Lumma WC; Machotka SV; Rands E; Williams TM; Graham SL; Hartman GD; Oliff AI; Heimbrook DC; Kohl NE
Cancer Res; 2001 Dec; 61(24):8758-68. PubMed ID: 11751396
[TBL] [Abstract][Full Text] [Related]
14. Alpha-interferon and its effects on signal transduction pathways.
Caraglia M; Marra M; Pelaia G; Maselli R; Caputi M; Marsico SA; Abbruzzese A
J Cell Physiol; 2005 Feb; 202(2):323-35. PubMed ID: 15389589
[TBL] [Abstract][Full Text] [Related]
15. Electromagnetic fields at mobile phone frequency induce apoptosis and inactivation of the multi-chaperone complex in human epidermoid cancer cells.
Caraglia M; Marra M; Mancinelli F; D'Ambrosio G; Massa R; Giordano A; Budillon A; Abbruzzese A; Bismuto E
J Cell Physiol; 2005 Aug; 204(2):539-48. PubMed ID: 15754340
[TBL] [Abstract][Full Text] [Related]
16. Characterization of a R115777-resistant human multiple myeloma cell line with cross-resistance to PS-341.
Buzzeo R; Enkemann S; Nimmanapalli R; Alsina M; Lichtenheld MG; Dalton WS; Beaupre DM
Clin Cancer Res; 2005 Aug; 11(16):6057-64. PubMed ID: 16115951
[TBL] [Abstract][Full Text] [Related]
17. Farnesyl transferase inhibitors: a major breakthrough in anticancer therapy? Naples, 12 April 2002.
Caponigro F
Anticancer Drugs; 2002 Sep; 13(8):891-7. PubMed ID: 12394276
[TBL] [Abstract][Full Text] [Related]
18. Synergistic antitumor activity of epidermal growth factor receptor tyrosine kinase inhibitor gefitinib and IFN-alpha in head and neck cancer cells in vitro and in vivo.
Bruzzese F; Di Gennaro E; Avallone A; Pepe S; Arra C; Caraglia M; Tagliaferri P; Budillon A
Clin Cancer Res; 2006 Jan; 12(2):617-25. PubMed ID: 16428508
[TBL] [Abstract][Full Text] [Related]
19. Antitumor activity of orally bioavailable farnesyltransferase inhibitor, ABT-100, is mediated by antiproliferative, proapoptotic, and antiangiogenic effects in xenograft models.
Ferguson D; Rodriguez LE; Palma JP; Refici M; Jarvis K; O'Connor J; Sullivan GM; Frost D; Marsh K; Bauch J; Zhang H; Lin NH; Rosenberg S; Sham HL; Joseph IB
Clin Cancer Res; 2005 Apr; 11(8):3045-54. PubMed ID: 15837760
[TBL] [Abstract][Full Text] [Related]
20. Effect of farnesyl transferase inhibitor R115777 on the growth of fresh and cloned myeloma cells in vitro.
Ochiai N; Uchida R; Fuchida S; Okano A; Okamoto M; Ashihara E; Inaba T; Fujita N; Matsubara H; Shimazaki C
Blood; 2003 Nov; 102(9):3349-53. PubMed ID: 12842991
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
