132 related articles for article (PubMed ID: 17682072)
1. A comparison of 2-phenyl-2-(1-piperidinyl)propane (ppp), 1,1',1''-phosphinothioylidynetrisaziridine (thioTEPA), clopidogrel, and ticlopidine as selective inactivators of human cytochrome P450 2B6.
Walsky RL; Obach RS
Drug Metab Dispos; 2007 Nov; 35(11):2053-9. PubMed ID: 17682072
[TBL] [Abstract][Full Text] [Related]
2. Mechanism-based inactivation of cytochromes P450 2B1 and P450 2B6 by 2-phenyl-2-(1-piperidinyl)propane.
Chun J; Kent UM; Moss RM; Sayre LM; Hollenberg PF
Drug Metab Dispos; 2000 Aug; 28(8):905-11. PubMed ID: 10901699
[TBL] [Abstract][Full Text] [Related]
3. Selective inhibition of CYP2B6-catalyzed bupropion hydroxylation in human liver microsomes in vitro.
Turpeinen M; Nieminen R; Juntunen T; Taavitsainen P; Raunio H; Pelkonen O
Drug Metab Dispos; 2004 Jun; 32(6):626-31. PubMed ID: 15155554
[TBL] [Abstract][Full Text] [Related]
4. Potent mechanism-based inhibition of human CYP2B6 by clopidogrel and ticlopidine.
Richter T; Mürdter TE; Heinkele G; Pleiss J; Tatzel S; Schwab M; Eichelbaum M; Zanger UM
J Pharmacol Exp Ther; 2004 Jan; 308(1):189-97. PubMed ID: 14563790
[TBL] [Abstract][Full Text] [Related]
5. Mechanism-based inhibition of human cytochrome P450 2B6 by ticlopidine, clopidogrel, and the thiolactone metabolite of prasugrel.
Nishiya Y; Hagihara K; Ito T; Tajima M; Miura S; Kurihara A; Farid NA; Ikeda T
Drug Metab Dispos; 2009 Mar; 37(3):589-93. PubMed ID: 19047469
[TBL] [Abstract][Full Text] [Related]
6. Inhibition of human CYP2B6 by N,N',N''-triethylenethiophosphoramide is irreversible and mechanism-based.
Richter T; Schwab M; Eichelbaum M; Zanger UM
Biochem Pharmacol; 2005 Feb; 69(3):517-24. PubMed ID: 15652242
[TBL] [Abstract][Full Text] [Related]
7. Potent inhibition of cytochrome P450 2B6 by sibutramine in human liver microsomes.
Bae SH; Kwon MJ; Choi EJ; Zheng YF; Yoon KD; Liu KH; Bae SK
Chem Biol Interact; 2013 Sep; 205(1):11-9. PubMed ID: 23777987
[TBL] [Abstract][Full Text] [Related]
8. Triethylenethiophosphoramide is a specific inhibitor of cytochrome P450 2B6: implications for cyclophosphamide metabolism.
Rae JM; Soukhova NV; Flockhart DA; Desta Z
Drug Metab Dispos; 2002 May; 30(5):525-30. PubMed ID: 11950782
[TBL] [Abstract][Full Text] [Related]
9. Evaluation of 227 drugs for in vitro inhibition of cytochrome P450 2B6.
Walsky RL; Astuccio AV; Obach RS
J Clin Pharmacol; 2006 Dec; 46(12):1426-38. PubMed ID: 17101742
[TBL] [Abstract][Full Text] [Related]
10. Validation of bupropion hydroxylation as a selective marker of human cytochrome P450 2B6 catalytic activity.
Faucette SR; Hawke RL; Lecluyse EL; Shord SS; Yan B; Laethem RM; Lindley CM
Drug Metab Dispos; 2000 Oct; 28(10):1222-30. PubMed ID: 10997944
[TBL] [Abstract][Full Text] [Related]
11. Cytochrome P450 2B6 catalyzes the formation of pharmacologically active sibutramine (N-{1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl}-N,N-dimethylamine) metabolites in human liver microsomes.
Bae SK; Cao S; Seo KA; Kim H; Kim MJ; Shon JH; Liu KH; Zhou HH; Shin JG
Drug Metab Dispos; 2008 Aug; 36(8):1679-88. PubMed ID: 18474675
[TBL] [Abstract][Full Text] [Related]
12. Comparison of in vitro metabolism of ticlopidine by human cytochrome P450 2B6 and rabbit cytochrome P450 2B4.
Talakad JC; Shah MB; Walker GS; Xiang C; Halpert JR; Dalvie D
Drug Metab Dispos; 2011 Mar; 39(3):539-50. PubMed ID: 21156812
[TBL] [Abstract][Full Text] [Related]
13. Comparison of mechanism-based inhibition of human cytochrome P450 2C19 by ticlopidine, clopidogrel, and prasugrel.
Nishiya Y; Hagihara K; Kurihara A; Okudaira N; Farid NA; Okazaki O; Ikeda T
Xenobiotica; 2009 Nov; 39(11):836-43. PubMed ID: 19845434
[TBL] [Abstract][Full Text] [Related]
14. Multiple cytochrome P450 isoforms are involved in the generation of a pharmacologically active thiol metabolite, whereas paraoxonase 1 and carboxylesterase 1 catalyze the formation of a thiol metabolite isomer from ticlopidine.
Kim MJ; Jeong ES; Park JS; Lee SJ; Ghim JL; Choi CS; Shin JG; Kim DH
Drug Metab Dispos; 2014 Jan; 42(1):141-52. PubMed ID: 24170778
[TBL] [Abstract][Full Text] [Related]
15. Mechanism-based inactivation of human cytochrome p450 enzymes and the prediction of drug-drug interactions.
Obach RS; Walsky RL; Venkatakrishnan K
Drug Metab Dispos; 2007 Feb; 35(2):246-55. PubMed ID: 17093004
[TBL] [Abstract][Full Text] [Related]
16. Inhibition and inactivation of human cytochrome P450 isoforms by phenethyl isothiocyanate.
Nakajima M; Yoshida R; Shimada N; Yamazaki H; Yokoi T
Drug Metab Dispos; 2001 Aug; 29(8):1110-3. PubMed ID: 11454729
[TBL] [Abstract][Full Text] [Related]
17. Orphenadrine and methimazole inhibit multiple cytochrome P450 enzymes in human liver microsomes.
Guo Z; Raeissi S; White RB; Stevens JC
Drug Metab Dispos; 1997 Mar; 25(3):390-3. PubMed ID: 9172960
[TBL] [Abstract][Full Text] [Related]
18. Effect of clopidogrel and ticlopidine on cytochrome P450 2B6 activity as measured by bupropion hydroxylation.
Turpeinen M; Tolonen A; Uusitalo J; Jalonen J; Pelkonen O; Laine K
Clin Pharmacol Ther; 2005 Jun; 77(6):553-9. PubMed ID: 15961986
[TBL] [Abstract][Full Text] [Related]
19. Mechanism-based inactivation of human cytochrome P450 2B6 by clopidogrel: involvement of both covalent modification of cysteinyl residue 475 and loss of heme.
Zhang H; Amunugama H; Ney S; Cooper N; Hollenberg PF
Mol Pharmacol; 2011 Nov; 80(5):839-47. PubMed ID: 21862689
[TBL] [Abstract][Full Text] [Related]
20. Metabolism of N,N',N"-triethylenethiophosphoramide by CYP2B1 and CYP2B6 results in the inactivation of both isoforms by two distinct mechanisms.
Harleton E; Webster M; Bumpus NN; Kent UM; Rae JM; Hollenberg PF
J Pharmacol Exp Ther; 2004 Sep; 310(3):1011-9. PubMed ID: 15121764
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
