205 related articles for article (PubMed ID: 1768258)
1. Antifolates induce primary inhibition of the de novo purine pathway prior to 5-aminoimidazole-4-carboxamide ribotide transformylase in leukemia cells.
Lyons SD; Christopherson RI
Biochem Int; 1991 May; 24(1):187-97. PubMed ID: 1768258
[TBL] [Abstract][Full Text] [Related]
2. Antifolates induce inhibition of amido phosphoribosyltransferase in leukemia cells.
Sant ME; Lyons SD; Phillips L; Christopherson RI
J Biol Chem; 1992 Jun; 267(16):11038-45. PubMed ID: 1597445
[TBL] [Abstract][Full Text] [Related]
3. Dual effects of pyrazofurin and 3-deazauridine upon pyrimidine and purine biosynthesis in mouse L1210 leukemia.
Sant ME; Lyons SD; Kemp AJ; McClure LK; Szabados E; Christopherson RI
Cancer Res; 1989 May; 49(10):2645-50. PubMed ID: 2713848
[TBL] [Abstract][Full Text] [Related]
4. Biochemical and biological studies on 2-desamino-2-methylaminopterin, an antifolate the polyglutamates of which are more potent than the monoglutamate against three key enzymes of folate metabolism.
Rosowsky A; Galivan J; Beardsley GP; Bader H; O'Connor BM; Russello O; Moroson BA; DeYarman MT; Kerwar SS; Freisheim JH
Cancer Res; 1992 Apr; 52(8):2148-55. PubMed ID: 1313737
[TBL] [Abstract][Full Text] [Related]
5. Inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase, adenosine deaminase and 5'-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide.
Baggott JE; Vaughn WH; Hudson BB
Biochem J; 1986 May; 236(1):193-200. PubMed ID: 2431676
[TBL] [Abstract][Full Text] [Related]
6. Evidence for direct inhibition of de novo purine synthesis in human MCF-7 breast cells as a principal mode of metabolic inhibition by methotrexate.
Allegra CJ; Hoang K; Yeh GC; Drake JC; Baram J
J Biol Chem; 1987 Oct; 262(28):13520-6. PubMed ID: 2443493
[TBL] [Abstract][Full Text] [Related]
7. LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes.
Shih C; Chen VJ; Gossett LS; Gates SB; MacKellar WC; Habeck LL; Shackelford KA; Mendelsohn LG; Soose DJ; Patel VF; Andis SL; Bewley JR; Rayl EA; Moroson BA; Beardsley GP; Kohler W; Ratnam M; Schultz RM
Cancer Res; 1997 Mar; 57(6):1116-23. PubMed ID: 9067281
[TBL] [Abstract][Full Text] [Related]
8. Antifolates in rheumatoid arthritis: a hypothetical mechanism of action.
Baggott JE; Morgan SL; Ha TS; Alarcón GS; Koopman WJ; Krumdieck CL
Clin Exp Rheumatol; 1993; 11 Suppl 8():S101-5. PubMed ID: 8324932
[TBL] [Abstract][Full Text] [Related]
9. Identification and biochemical properties of 10-formyldihydrofolate, a novel folate found in methotrexate-treated cells.
Baram J; Chabner BA; Drake JC; Fitzhugh AL; Sholar PW; Allegra CJ
J Biol Chem; 1988 May; 263(15):7105-11. PubMed ID: 3366769
[TBL] [Abstract][Full Text] [Related]
10. The effect of methotrexate and 7-hydroxymethotrexate on rat adjuvant arthritis and on urinary aminoimidazole carboxamide excretion.
Baggott JE; Morgan SL; Koopman WJ
Arthritis Rheum; 1998 Aug; 41(8):1407-10. PubMed ID: 9704638
[TBL] [Abstract][Full Text] [Related]
11. Chromatographic analysis of purine precursors in mouse L1210 leukemia.
Sant ME; Poiner A; Harsanyi MC; Lyons SD; Christopherson RI
Anal Biochem; 1989 Oct; 182(1):121-8. PubMed ID: 2604037
[TBL] [Abstract][Full Text] [Related]
12. 5-Aminoimidazole-4-carboxamide ribotide transformylase-IMP cyclohydrolase from human CCRF-CEM leukemia cells: purification, pH dependence, and inhibitors.
Szabados E; Hindmarsh EJ; Phillips L; Duggleby RG; Christopherson RI
Biochemistry; 1994 Nov; 33(47):14237-45. PubMed ID: 7947835
[TBL] [Abstract][Full Text] [Related]
13. Novel pyrrolo[2,3-d]pyrimidine antifolate TNP-351: cytotoxic effect on methotrexate-resistant CCRF-CEM cells and inhibition of transformylases of de novo purine biosynthesis.
Itoh F; Russello O; Akimoto H; Beardsley GP
Cancer Chemother Pharmacol; 1994; 34(4):273-9. PubMed ID: 8033293
[TBL] [Abstract][Full Text] [Related]
14. Radioassay of bifunctional 5-aminoimidazole-4-carboxamide ribotide transformylase-IMP cyclohydrolase by thin-layer chromatography.
Szabados E; Christopherson RI
Anal Biochem; 1994 Sep; 221(2):401-4. PubMed ID: 7810885
[TBL] [Abstract][Full Text] [Related]
15. Multifactorial resistance to 5,10-dideazatetrahydrofolic acid in cell lines derived from human lymphoblastic leukemia CCRF-CEM.
Pizzorno G; Moroson BA; Cashmore AR; Russello O; Mayer JR; Galivan J; Bunni MA; Priest DG; Beardsley GP
Cancer Res; 1995 Feb; 55(3):566-73. PubMed ID: 7834626
[TBL] [Abstract][Full Text] [Related]
16. On the cofactor specificity of glycinamide ribonucleotide and 5-aminoimidazole-4-carboxamide ribonucleotide transformylase from chicken liver.
Smith GK; Mueller WT; Benkovic PA; Benkovic SJ
Biochemistry; 1981 Mar; 20(5):1241-5. PubMed ID: 7225325
[TBL] [Abstract][Full Text] [Related]
17. Induction of HL-60 leukemia cell differentiation by the novel antifolate 5,10-dideazatetrahydrofolic acid.
Sokoloski JA; Beardsley GP; Sartorelli AC
Cancer Res; 1989 Sep; 49(17):4824-8. PubMed ID: 2758415
[TBL] [Abstract][Full Text] [Related]
18. Differences in methotrexate and 7-hydroxymethotrexate inhibition of folate-dependent enzymes of purine nucleotide biosynthesis.
Baggott JE; Morgan SL; Vaughn WH
Biochem J; 1994 Jun; 300 ( Pt 3)(Pt 3):627-9. PubMed ID: 8010943
[TBL] [Abstract][Full Text] [Related]
19. Synthesis and antifolate activity of 5-methyl-5,10-dideaza analogues of aminopterin and folic acid and an alternative synthesis of 5,10-dideazatetrahydrofolic acid, a potent inhibitor of glycinamide ribonucleotide formyltransferase.
Piper JR; McCaleb GS; Montgomery JA; Kisliuk RL; Gaumont Y; Thorndike J; Sirotnak FM
J Med Chem; 1988 Nov; 31(11):2164-9. PubMed ID: 3184124
[TBL] [Abstract][Full Text] [Related]
20. Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid.
Kelley JL; McLean EW; Cohn NK; Edelstein MP; Duch DS; Smith GK; Hanlon MH; Ferone R
J Med Chem; 1990 Feb; 33(2):561-7. PubMed ID: 2299624
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
