BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

289 related articles for article (PubMed ID: 17687072)

  • 1. Positive and negative regulation of human hepatic hydroxysteroid sulfotransferase (SULT2A1) gene transcription by rifampicin: roles of hepatocyte nuclear factor 4alpha and pregnane X receptor.
    Fang HL; Strom SC; Ellis E; Duanmu Z; Fu J; Duniec-Dmuchowski Z; Falany CN; Falany JL; Kocarek TA; Runge-Morris M
    J Pharmacol Exp Ther; 2007 Nov; 323(2):586-98. PubMed ID: 17687072
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Rifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4alpha and coactivators, and suppression of small heterodimer partner gene expression.
    Li T; Chiang JY
    Drug Metab Dispos; 2006 May; 34(5):756-64. PubMed ID: 16455805
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7 alpha-hydroxylase gene transcription.
    Li T; Chiang JY
    Am J Physiol Gastrointest Liver Physiol; 2005 Jan; 288(1):G74-84. PubMed ID: 15331348
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1alpha. Functional implications in hepatic cholesterol and glucose metabolism.
    Bhalla S; Ozalp C; Fang S; Xiang L; Kemper JK
    J Biol Chem; 2004 Oct; 279(43):45139-47. PubMed ID: 15322103
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways.
    Cerveny L; Svecova L; Anzenbacherova E; Vrzal R; Staud F; Dvorak Z; Ulrichova J; Anzenbacher P; Pavek P
    Drug Metab Dispos; 2007 Jul; 35(7):1032-41. PubMed ID: 17392393
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4alpha in the regulation of human steroid-/bile acid-sulfotransferase.
    Echchgadda I; Song CS; Oh T; Ahmed M; De La Cruz IJ; Chatterjee B
    Mol Endocrinol; 2007 Sep; 21(9):2099-111. PubMed ID: 17595319
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Lower expression of HNF4α and PGC1α might impair rifampicin-mediated CYP3A4 induction under conditions where PXR is overexpressed in human fetal liver cells.
    Takezawa T; Matsunaga T; Aikawa K; Nakamura K; Ohmori S
    Drug Metab Pharmacokinet; 2012; 27(4):430-8. PubMed ID: 22333269
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The far and distal enhancers in the CYP3A4 gene co-ordinate the proximal promoter in responding similarly to the pregnane X receptor but differentially to hepatocyte nuclear factor-4alpha.
    Liu FJ; Song X; Yang D; Deng R; Yan B
    Biochem J; 2008 Jan; 409(1):243-50. PubMed ID: 17764444
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Role of human hepatocyte nuclear factor 4alpha in the expression of drug-metabolizing enzymes and transporters in human hepatocytes assessed by use of small interfering RNA.
    Kamiyama Y; Matsubara T; Yoshinari K; Nagata K; Kamimura H; Yamazoe Y
    Drug Metab Pharmacokinet; 2007 Aug; 22(4):287-98. PubMed ID: 17827783
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression.
    Svecova L; Vrzal R; Burysek L; Anzenbacherova E; Cerveny L; Grim J; Trejtnar F; Kunes J; Pour M; Staud F; Anzenbacher P; Dvorak Z; Pavek P
    Drug Metab Dispos; 2008 Feb; 36(2):339-48. PubMed ID: 17998298
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Hepatocyte nuclear factor 4{alpha} regulates rifampicin-mediated induction of CYP2C genes in primary cultures of human hepatocytes.
    Rana R; Chen Y; Ferguson SS; Kissling GE; Surapureddi S; Goldstein JA
    Drug Metab Dispos; 2010 Apr; 38(4):591-9. PubMed ID: 20086032
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Inhibition of CYP3A4 expression by ketoconazole is mediated by the disruption of pregnane X receptor, steroid receptor coactivator-1, and hepatocyte nuclear factor 4alpha interaction.
    Lim YP; Kuo SC; Lai ML; Huang JD
    Pharmacogenet Genomics; 2009 Jan; 19(1):11-24. PubMed ID: 19077665
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module.
    Goodwin B; Hodgson E; Liddle C
    Mol Pharmacol; 1999 Dec; 56(6):1329-39. PubMed ID: 10570062
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The nuclear receptors constitutive androstane receptor and pregnane X receptor cross-talk with hepatic nuclear factor 4alpha to synergistically activate the human CYP2C9 promoter.
    Chen Y; Kissling G; Negishi M; Goldstein JA
    J Pharmacol Exp Ther; 2005 Sep; 314(3):1125-33. PubMed ID: 15919766
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Suppression of the pregnane X receptor during endoplasmic reticulum stress is achieved by down-regulating hepatocyte nuclear factor-4α and up-regulating liver-enriched inhibitory protein.
    Vachirayonsti T; Ho KW; Yang D; Yan B
    Toxicol Sci; 2015 Apr; 144(2):382-92. PubMed ID: 25616597
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Liganded pregnane X receptor represses the human sulfotransferase SULT1E1 promoter through disrupting its chromatin structure.
    Kodama S; Hosseinpour F; Goldstein JA; Negishi M
    Nucleic Acids Res; 2011 Oct; 39(19):8392-403. PubMed ID: 21764778
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Induction of human CYP2A6 is mediated by the pregnane X receptor with peroxisome proliferator-activated receptor-gamma coactivator 1alpha.
    Itoh M; Nakajima M; Higashi E; Yoshida R; Nagata K; Yamazoe Y; Yokoi T
    J Pharmacol Exp Ther; 2006 Nov; 319(2):693-702. PubMed ID: 16857725
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha.
    Ferguson SS; Chen Y; LeCluyse EL; Negishi M; Goldstein JA
    Mol Pharmacol; 2005 Sep; 68(3):747-57. PubMed ID: 15933212
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor.
    Pascussi JM; Drocourt L; Gerbal-Chaloin S; Fabre JM; Maurel P; Vilarem MJ
    Eur J Biochem; 2001 Dec; 268(24):6346-58. PubMed ID: 11737189
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The pregnane X receptor binds to response elements in a genomic context-dependent manner, and PXR activator rifampicin selectively alters the binding among target genes.
    Song X; Xie M; Zhang H; Li Y; Sachdeva K; Yan B
    Drug Metab Dispos; 2004 Jan; 32(1):35-42. PubMed ID: 14709618
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.