102 related articles for article (PubMed ID: 17688078)
1. Large-scale synthesis of GMP grade N'- [2-(2-thiophene) ethyl]-N'- [2- (5-bromopyridyl)] -thiourea (HI-443), a new anti-HIV drug candidate.
DuMez D; Venkatachalam TK; Uckun FM
Arzneimittelforschung; 2007; 57(6):330-8. PubMed ID: 17688078
[TBL] [Abstract][Full Text] [Related]
2. N'-[2-(2-thiophene) ethyl]-N'-[2-(5-bromopyridyl)]thiourea (HI-443), a rationally designed non-nucleoside reverse transcriptase inhibitor compound with potent anti-HIV activity.
Uckun FM; Qazi S; Venkatachalam T
Arzneimittelforschung; 2007; 57(5):278-85. PubMed ID: 17598700
[TBL] [Abstract][Full Text] [Related]
3. In vivo pharmacokinetics, metabolism, toxicity, and anti-HIV activity of N'-[2-(2-Thiophene)ethyl]-N'-[2-(5-bromopyridyl)]thiourea (HI-443), a potent non-nucleoside inhibitor of HIV reverse transcriptase.
Uckun FM; Tibbles HE; Venkatachalam TK; Erbeck D
Arzneimittelforschung; 2007; 57(7):483-96. PubMed ID: 17803063
[TBL] [Abstract][Full Text] [Related]
4. In vivo pharmacokinetics and toxicity of a novel hydrophilic oral formulation of the potent non-nucleoside reverse transcriptase inhibitor compound N'-[2-(2-thiophene)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea (HI-443).
Uckun FM; Tibbles H; Erbeck D; Venkatachalam TK; Qazi S
Arzneimittelforschung; 2007; 57(4):218-26. PubMed ID: 17515292
[TBL] [Abstract][Full Text] [Related]
5. Improved oral bioavailability of anti-HIV agent N'-[2-(2-thiophene)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea (HI-443) in a novel lipophilic formulation.
Uckun FM; Erbeck D; Tibbles H; Qazi S; Venkatachalam TK
Arzneimittelforschung; 2007; 57(3):164-70. PubMed ID: 17469651
[TBL] [Abstract][Full Text] [Related]
6. A novel vaginal microbicide containing the rationally designed anti-HIV compound HI-443 (N'-[2-(2-thiophene)ethyl]-N'-[2-(5-bromopyridyl)] thiourea]).
D'Cruz OJ; Qazi S; Yiv S; Uckun FM
Expert Opin Investig Drugs; 2012 Mar; 21(3):265-79. PubMed ID: 22292483
[TBL] [Abstract][Full Text] [Related]
7. Structure-based design of non-nucleoside reverse transcriptase inhibitors of drug-resistant human immunodeficiency virus.
Mao C; Sudbeck EA; Venkatachalam TK; Uckun FM
Antivir Chem Chemother; 1999 Sep; 10(5):233-40. PubMed ID: 10574178
[TBL] [Abstract][Full Text] [Related]
8. Large-scale synthesis of GMP grade alpha-cyano-beta-hydroxy-beta-methyl-N-(2,5-dibromophenyl) propenamide (LFM-A13), a new anti-cancer drug candidate.
DuMez D; Venkatachalam TK; Uckun FM
Arzneimittelforschung; 2007; 57(3):155-63. PubMed ID: 17469650
[TBL] [Abstract][Full Text] [Related]
9. In vivo toxicity, pharmacokinetic features and tissue distribution of N-[2-(2,5-dimethoxyphenylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea (HI-236), a potent non-nucleoside inhibitor of HIV-1 reverse transcriptase.
Chen CL; Venkatachalam TK; Waurzyniak B; Chelstrom L; Uckun FM
Arzneimittelforschung; 2001; 51(7):574-81. PubMed ID: 11505789
[TBL] [Abstract][Full Text] [Related]
10. Rational design of N-[2-(2,5-dimethoxyphenylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea (HI-236) as a potent non-nucleoside inhibitor of drug-resistant human immunodeficiency virus.
Mao C; Sudbeck EA; Venkatachalam TK; Uckun FM
Bioorg Med Chem Lett; 1999 Jun; 9(11):1593-8. PubMed ID: 10386942
[TBL] [Abstract][Full Text] [Related]
11. N-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea and N'-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-chloropyridyl)]-thiourea as potent inhibitors of multidrug-resistant human immunodeficiency virus-1.
Uckun FM; Mao C; Pendergrass S; Maher D; Zhu D; Tuel-Ahlgren L; Venkatachalam TK
Bioorg Med Chem Lett; 1999 Sep; 9(18):2721-6. PubMed ID: 10509923
[TBL] [Abstract][Full Text] [Related]
12. N'-[2-(2-thiophene)ethyl]-N'-[2-(5-bromopyridyl)] thiourea as a potent inhibitor of NNI-resistant and multidrug-resistant human immunodeficiency virus-1.
Uckun FM; Pendergrass S; Maher D; Zhu D; Tuel-Ahlgren L; Mao C; Venkatachalam TK
Bioorg Med Chem Lett; 1999 Dec; 9(24):3411-6. PubMed ID: 10617082
[TBL] [Abstract][Full Text] [Related]
13. Large-scale synthesis and formulation of GMP-grade stampidine, a new anti-HIV agent.
DuMez D; Venkatachalam TK; Uckun FM
Arzneimittelforschung; 2006 Feb; 56(2A):136-51. PubMed ID: 16570822
[TBL] [Abstract][Full Text] [Related]
14. Structure-based design of N-[2-(1-piperidinylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea and N-[2-(1-piperazinylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea as potent non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Mao C; Vig R; Venkatachalam TK; Sudbeck EA; Uckun FM
Bioorg Med Chem Lett; 1998 Aug; 8(16):2213-8. PubMed ID: 9873515
[TBL] [Abstract][Full Text] [Related]
15. N-[2-(4-methylphenyl)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea as a potent inhibitor of NNRTI-resistant and multidrug-resistant human immunodeficiency virus type 1.
Uckun FM; Mao C; Pendergrass S; Maher D; Zhu D; Tuel-Ahlgren L; Venkatachalam TK
Antivir Chem Chemother; 2000 Mar; 11(2):135-40. PubMed ID: 10819437
[TBL] [Abstract][Full Text] [Related]
16. Discovery of 2,5-dimethoxy-substituted 5-bromopyridyl thiourea (PHI-236) as a potent broad-spectrum anti-human immunodeficiency virus microbicide.
D'Cruz OJ; Uckun FM
Mol Hum Reprod; 2005 Oct; 11(10):767-77. PubMed ID: 16254003
[TBL] [Abstract][Full Text] [Related]
17. Evaluation of the pharmacokinetic features and tissue distribution of the potent nonnucleoside inhibitor of HIV-1 reverse transcriptase, N-[2-(2-fluorophenethyl)]-N'-[2-(5-bromopyridyl)]-thiourea (HI-240) with an analytical HPLC method.
Chen CL; Uckun FM
Pharm Res; 1999 Aug; 16(8):1226-32. PubMed ID: 10468024
[TBL] [Abstract][Full Text] [Related]
18. [d4U]-butyne-[HI-236] as a non-cleavable, bifunctional NRTI/NNRTI HIV-1 reverse-transcriptase inhibitor.
Hunter R; Muhanji CI; Hale I; Bailey CM; Basavapathruni A; Anderson KS
Bioorg Med Chem Lett; 2007 May; 17(9):2614-7. PubMed ID: 17317163
[TBL] [Abstract][Full Text] [Related]
19. Piperidinylethyl, phenoxyethyl and fluoroethyl bromopyridyl thiourea compounds with potent anti-HIV activity.
Venkatachalam TK; Sudbec EA; Mao C; Uckun FM
Antivir Chem Chemother; 2000 Sep; 11(5):329-36. PubMed ID: 11142631
[TBL] [Abstract][Full Text] [Related]
20. Stereochemistry of halopyridyl and thiazolyl thiourea compounds is a major determinant of their potency as nonnucleoside inhibitors of HIV-1 reverse transcriptase.
Venkatachalam TK; Sudbeck EA; Mao C; Uckun FM
Bioorg Med Chem Lett; 2000 Sep; 10(18):2071-4. PubMed ID: 10999473
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
