These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

112 related articles for article (PubMed ID: 17698850)

  • 1. Human T-cell leukemia virus type 1 Tax oncoprotein prevents DNA damage-induced chromatin egress of hyperphosphorylated Chk2.
    Gupta SK; Guo X; Durkin SS; Fryrear KF; Ward MD; Semmes OJ
    J Biol Chem; 2007 Oct; 282(40):29431-40. PubMed ID: 17698850
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Interdependent phosphorylation within the kinase domain T-loop Regulates CHK2 activity.
    Guo X; Ward MD; Tiedebohl JB; Oden YM; Nyalwidhe JO; Semmes OJ
    J Biol Chem; 2010 Oct; 285(43):33348-33357. PubMed ID: 20713355
    [TBL] [Abstract][Full Text] [Related]  

  • 3. HTLV-1 Tax oncoprotein subverts the cellular DNA damage response via binding to DNA-dependent protein kinase.
    Durkin SS; Guo X; Fryrear KA; Mihaylova VT; Gupta SK; Belgnaoui SM; Haoudi A; Kupfer GM; Semmes OJ
    J Biol Chem; 2008 Dec; 283(52):36311-20. PubMed ID: 18957425
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Human T-cell leukemia virus-I tax oncoprotein functionally targets a subnuclear complex involved in cellular DNA damage-response.
    Haoudi A; Daniels RC; Wong E; Kupfer G; Semmes OJ
    J Biol Chem; 2003 Sep; 278(39):37736-44. PubMed ID: 12842897
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The viral oncoprotein tax sequesters DNA damage response factors by tethering MDC1 to chromatin.
    Belgnaoui SM; Fryrear KA; Nyalwidhe JO; Guo X; Semmes OJ
    J Biol Chem; 2010 Oct; 285(43):32897-32905. PubMed ID: 20729195
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Human T-cell leukemia virus type 1 Tax attenuates gamma-irradiation-induced apoptosis through physical interaction with Chk2.
    Park HU; Jeong SJ; Jeong JH; Chung JH; Brady JN
    Oncogene; 2006 Jan; 25(3):438-47. PubMed ID: 16158050
    [TBL] [Abstract][Full Text] [Related]  

  • 7. DNA damage regulates Chk2 association with chromatin.
    Li J; Stern DF
    J Biol Chem; 2005 Nov; 280(45):37948-56. PubMed ID: 16150728
    [TBL] [Abstract][Full Text] [Related]  

  • 8. TTK/hMps1 participates in the regulation of DNA damage checkpoint response by phosphorylating CHK2 on threonine 68.
    Wei JH; Chou YF; Ou YH; Yeh YH; Tyan SW; Sun TP; Shen CY; Shieh SY
    J Biol Chem; 2005 Mar; 280(9):7748-57. PubMed ID: 15618221
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain.
    Ahn JY; Li X; Davis HL; Canman CE
    J Biol Chem; 2002 May; 277(22):19389-95. PubMed ID: 11901158
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosis.
    Wu X; Chen J
    J Biol Chem; 2003 Sep; 278(38):36163-8. PubMed ID: 12855706
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Site-specific phosphorylation differentiates active from inactive forms of the human T-cell leukemia virus type 1 Tax oncoprotein.
    Durkin SS; Ward MD; Fryrear KA; Semmes OJ
    J Biol Chem; 2006 Oct; 281(42):31705-12. PubMed ID: 16923801
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage.
    Bahassi el M; Myer DL; McKenney RJ; Hennigan RF; Stambrook PJ
    Mutat Res; 2006 Apr; 596(1-2):166-76. PubMed ID: 16481012
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks.
    Ward IM; Wu X; Chen J
    J Biol Chem; 2001 Dec; 276(51):47755-8. PubMed ID: 11668173
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage.
    Bahassi EM; Ovesen JL; Riesenberg AL; Bernstein WZ; Hasty PE; Stambrook PJ
    Oncogene; 2008 Jun; 27(28):3977-85. PubMed ID: 18317453
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379.
    Lovly CM; Yan L; Ryan CE; Takada S; Piwnica-Worms H
    Mol Cell Biol; 2008 Oct; 28(19):5874-85. PubMed ID: 18644861
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species.
    Kurz EU; Douglas P; Lees-Miller SP
    J Biol Chem; 2004 Dec; 279(51):53272-81. PubMed ID: 15489221
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis.
    Falck J; Mailand N; Syljuåsen RG; Bartek J; Lukas J
    Nature; 2001 Apr; 410(6830):842-7. PubMed ID: 11298456
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Allosteric effects mediate CHK2 phosphorylation of the p53 transactivation domain.
    Craig A; Scott M; Burch L; Smith G; Ball K; Hupp T
    EMBO Rep; 2003 Aug; 4(8):787-92. PubMed ID: 12897801
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Intrinsic kinase activity and SQ/TQ domain of Chk2 kinase as well as N-terminal domain of Wip1 phosphatase are required for regulation of Chk2 by Wip1.
    Yoda A; Xu XZ; Onishi N; Toyoshima K; Fujimoto H; Kato N; Oishi I; Kondo T; Minami Y
    J Biol Chem; 2006 Aug; 281(34):24847-62. PubMed ID: 16798742
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Stability of checkpoint kinase 2 is regulated via phosphorylation at serine 456.
    Kass EM; Ahn J; Tanaka T; Freed-Pastor WA; Keezer S; Prives C
    J Biol Chem; 2007 Oct; 282(41):30311-21. PubMed ID: 17715138
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.