BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

1070 related articles for article (PubMed ID: 17713585)

  • 1. Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.
    Williams RS; Williams JS; Tainer JA
    Biochem Cell Biol; 2007 Aug; 85(4):509-20. PubMed ID: 17713585
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex.
    Lee JH; Mand MR; Deshpande RA; Kinoshita E; Yang SH; Wyman C; Paull TT
    J Biol Chem; 2013 May; 288(18):12840-51. PubMed ID: 23525106
    [TBL] [Abstract][Full Text] [Related]  

  • 3. ATP puts the brake on DNA double-strand break repair: a new study shows that ATP switches the Mre11-Rad50-Nbs1 repair factor between signaling and processing of DNA ends.
    Hopfner KP
    Bioessays; 2014 Dec; 36(12):1170-8. PubMed ID: 25213441
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The Mre11/Rad50/Nbs1 complex and its role as a DNA double-strand break sensor for ATM.
    Paull TT; Lee JH
    Cell Cycle; 2005 Jun; 4(6):737-40. PubMed ID: 15908798
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Dancing on damaged chromatin: functions of ATM and the RAD50/MRE11/NBS1 complex in cellular responses to DNA damage.
    Iijima K; Ohara M; Seki R; Tauchi H
    J Radiat Res; 2008 Sep; 49(5):451-64. PubMed ID: 18772547
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks.
    Takemura H; Rao VA; Sordet O; Furuta T; Miao ZH; Meng L; Zhang H; Pommier Y
    J Biol Chem; 2006 Oct; 281(41):30814-23. PubMed ID: 16905549
    [TBL] [Abstract][Full Text] [Related]  

  • 7. ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex.
    Lee JH; Paull TT
    Science; 2005 Apr; 308(5721):551-4. PubMed ID: 15790808
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm.
    Cerosaletti K; Concannon P
    J Biol Chem; 2004 Sep; 279(37):38813-9. PubMed ID: 15234984
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Rad50 zinc hook is important for the Mre11 complex to bind chromosomal DNA double-stranded breaks and initiate various DNA damage responses.
    He J; Shi LZ; Truong LN; Lu CS; Razavian N; Li Y; Negrete A; Shiloach J; Berns MW; Wu X
    J Biol Chem; 2012 Sep; 287(38):31747-56. PubMed ID: 22833675
    [TBL] [Abstract][Full Text] [Related]  

  • 10. MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks.
    Helmink BA; Bredemeyer AL; Lee BS; Huang CY; Sharma GG; Walker LM; Bednarski JJ; Lee WL; Pandita TK; Bassing CH; Sleckman BP
    J Exp Med; 2009 Mar; 206(3):669-79. PubMed ID: 19221393
    [TBL] [Abstract][Full Text] [Related]  

  • 11. NBS1 is regulated by two kind of mechanisms: ATM-dependent complex formation with MRE11 and RAD50, and cell cycle-dependent degradation of protein.
    Zhou H; Kawamura K; Yanagihara H; Kobayashi J; Zhang-Akiyama QM
    J Radiat Res; 2017 Jul; 58(4):487-494. PubMed ID: 28369484
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The Mre11/Rad50/Nbs1 complex plays an important role in the prevention of DNA rereplication in mammalian cells.
    Lee AY; Liu E; Wu X
    J Biol Chem; 2007 Nov; 282(44):32243-55. PubMed ID: 17715134
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Localization of Double-Strand Break Repair Proteins to Viral Replication Compartments following Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus.
    Hollingworth R; Horniblow RD; Forrest C; Stewart GS; Grand RJ
    J Virol; 2017 Nov; 91(22):. PubMed ID: 28855246
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex.
    Dupré A; Boyer-Chatenet L; Gautier J
    Nat Struct Mol Biol; 2006 May; 13(5):451-7. PubMed ID: 16622404
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks.
    Wang Q; Goldstein M; Alexander P; Wakeman TP; Sun T; Feng J; Lou Z; Kastan MB; Wang XF
    EMBO J; 2014 Apr; 33(8):862-77. PubMed ID: 24534091
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity.
    Jazayeri A; Balestrini A; Garner E; Haber JE; Costanzo V
    EMBO J; 2008 Jul; 27(14):1953-62. PubMed ID: 18596698
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis.
    Taylor AM; Groom A; Byrd PJ
    DNA Repair (Amst); 2004; 3(8-9):1219-25. PubMed ID: 15279810
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Cleavage of the BRCT tandem domains of nibrin by the 657del5 mutation affects the DNA damage response less than the Arg215Trp mutation.
    Mendez G; Cilli D; Berardinelli F; Viganotti M; Ascenzi P; Tanzarella C; Antoccia A; di Masi A
    IUBMB Life; 2012 Oct; 64(10):853-61. PubMed ID: 22941933
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATM.
    Yoo HY; Kumagai A; Shevchenko A; Shevchenko A; Dunphy WG
    Mol Biol Cell; 2009 May; 20(9):2351-60. PubMed ID: 19279141
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repair.
    Lafrance-Vanasse J; Williams GJ; Tainer JA
    Prog Biophys Mol Biol; 2015 Mar; 117(2-3):182-193. PubMed ID: 25576492
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 54.