321 related articles for article (PubMed ID: 17721440)
1. Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8-substrate complex.
Vannini A; Volpari C; Gallinari P; Jones P; Mattu M; Carfí A; De Francesco R; Steinkühler C; Di Marco S
EMBO Rep; 2007 Sep; 8(9):879-84. PubMed ID: 17721440
[TBL] [Abstract][Full Text] [Related]
2. Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases.
Somoza JR; Skene RJ; Katz BA; Mol C; Ho JD; Jennings AJ; Luong C; Arvai A; Buggy JJ; Chi E; Tang J; Sang BC; Verner E; Wynands R; Leahy EM; Dougan DR; Snell G; Navre M; Knuth MW; Swanson RV; McRee DE; Tari LW
Structure; 2004 Jul; 12(7):1325-34. PubMed ID: 15242608
[TBL] [Abstract][Full Text] [Related]
3. HDAC8 substrates: Histones and beyond.
Wolfson NA; Pitcairn CA; Fierke CA
Biopolymers; 2013 Feb; 99(2):112-26. PubMed ID: 23175386
[TBL] [Abstract][Full Text] [Related]
4. Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor.
Vannini A; Volpari C; Filocamo G; Casavola EC; Brunetti M; Renzoni D; Chakravarty P; Paolini C; De Francesco R; Gallinari P; Steinkühler C; Di Marco S
Proc Natl Acad Sci U S A; 2004 Oct; 101(42):15064-9. PubMed ID: 15477595
[TBL] [Abstract][Full Text] [Related]
5. Novel structural insights into class I and II histone deacetylases.
Ficner R
Curr Top Med Chem; 2009; 9(3):235-40. PubMed ID: 19355988
[TBL] [Abstract][Full Text] [Related]
6. Structure-Based Identification of HDAC8 Non-histone Substrates.
Alam N; Zimmerman L; Wolfson NA; Joseph CG; Fierke CA; Schueler-Furman O
Structure; 2016 Mar; 24(3):458-68. PubMed ID: 26933971
[TBL] [Abstract][Full Text] [Related]
7. Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors.
Dowling DP; Gantt SL; Gattis SG; Fierke CA; Christianson DW
Biochemistry; 2008 Dec; 47(51):13554-63. PubMed ID: 19053282
[TBL] [Abstract][Full Text] [Related]
8. Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors.
Krennhrubec K; Marshall BL; Hedglin M; Verdin E; Ulrich SM
Bioorg Med Chem Lett; 2007 May; 17(10):2874-8. PubMed ID: 17346959
[TBL] [Abstract][Full Text] [Related]
9. Phosphorylation of Histone Deacetylase 8: Structural and Mechanistic Analysis of the Phosphomimetic S39E Mutant.
Welker Leng KR; Castañeda CA; Decroos C; Islam B; Haider SM; Christianson DW; Fierke CA
Biochemistry; 2019 Nov; 58(45):4480-4493. PubMed ID: 31633931
[TBL] [Abstract][Full Text] [Related]
10. HDAC8 substrate selectivity is determined by long- and short-range interactions leading to enhanced reactivity for full-length histone substrates compared with peptides.
Castañeda CA; Wolfson NA; Leng KR; Kuo YM; Andrews AJ; Fierke CA
J Biol Chem; 2017 Dec; 292(52):21568-21577. PubMed ID: 29109148
[TBL] [Abstract][Full Text] [Related]
11. Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.
Marek M; Shaik TB; Heimburg T; Chakrabarti A; Lancelot J; Ramos-Morales E; Da Veiga C; Kalinin D; Melesina J; Robaa D; Schmidtkunz K; Suzuki T; Holl R; Ennifar E; Pierce RJ; Jung M; Sippl W; Romier C
J Med Chem; 2018 Nov; 61(22):10000-10016. PubMed ID: 30347148
[TBL] [Abstract][Full Text] [Related]
12. Biochemical and structural characterization of HDAC8 mutants associated with Cornelia de Lange syndrome spectrum disorders.
Decroos C; Christianson NH; Gullett LE; Bowman CM; Christianson KE; Deardorff MA; Christianson DW
Biochemistry; 2015 Oct; 54(42):6501-13. PubMed ID: 26463496
[TBL] [Abstract][Full Text] [Related]
13. Preparation of a new construct of human histone deacetylase 8 for the crystallization of enzyme-inhibitor complexes.
Porter NJ; Christianson DW
Methods Enzymol; 2019; 626():561-585. PubMed ID: 31606091
[TBL] [Abstract][Full Text] [Related]
14. Covalent inhibition of histone deacetylase 8 by 3,4-dihydro-2H-pyrimido[1,2-c][1,3]benzothiazin-6-imine.
Muth M; Jänsch N; Kopranovic A; Krämer A; Wössner N; Jung M; Kirschhöfer F; Brenner-Weiß G; Meyer-Almes FJ
Biochim Biophys Acta Gen Subj; 2019 Mar; 1863(3):577-585. PubMed ID: 30611847
[TBL] [Abstract][Full Text] [Related]
15. Docking of hydroxamic acids into HDAC1 and HDAC8: a rationalization of activity trends and selectivities.
Ortore G; Di Colo F; Martinelli A
J Chem Inf Model; 2009 Dec; 49(12):2774-85. PubMed ID: 19947584
[TBL] [Abstract][Full Text] [Related]
16. Binding of the Microbial Cyclic Tetrapeptide Trapoxin A to the Class I Histone Deacetylase HDAC8.
Porter NJ; Christianson DW
ACS Chem Biol; 2017 Sep; 12(9):2281-2286. PubMed ID: 28846375
[TBL] [Abstract][Full Text] [Related]
17. Cloning and characterization of a novel human class I histone deacetylase that functions as a transcription repressor.
Hu E; Chen Z; Fredrickson T; Zhu Y; Kirkpatrick R; Zhang GF; Johanson K; Sung CM; Liu R; Winkler J
J Biol Chem; 2000 May; 275(20):15254-64. PubMed ID: 10748112
[TBL] [Abstract][Full Text] [Related]
18. Structure of 'linkerless' hydroxamic acid inhibitor-HDAC8 complex confirms the formation of an isoform-specific subpocket.
Tabackman AA; Frankson R; Marsan ES; Perry K; Cole KE
J Struct Biol; 2016 Sep; 195(3):373-378. PubMed ID: 27374062
[TBL] [Abstract][Full Text] [Related]
19. HDAC8: a multifaceted target for therapeutic interventions.
Chakrabarti A; Oehme I; Witt O; Oliveira G; Sippl W; Romier C; Pierce RJ; Jung M
Trends Pharmacol Sci; 2015 Jul; 36(7):481-92. PubMed ID: 26013035
[TBL] [Abstract][Full Text] [Related]
20. Members of the histone deacetylase superfamily differ in substrate specificity towards small synthetic substrates.
Riester D; Wegener D; Hildmann C; Schwienhorst A
Biochem Biophys Res Commun; 2004 Nov; 324(3):1116-23. PubMed ID: 15485670
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]