BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

121 related articles for article (PubMed ID: 17723296)

  • 1. Synthesis and SAR of 2-aryl pyrido[2,3-d]pyrimidines as potent mGlu5 receptor antagonists.
    Wendt JA; Deeter SD; Bove SE; Knauer CS; Brooker RM; Augelli-Szafran CE; Schwarz RD; Kinsora JJ; Kilgore KS
    Bioorg Med Chem Lett; 2007 Oct; 17(19):5396-9. PubMed ID: 17723296
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists.
    Galatsis P; Yamagata K; Wendt JA; Connolly CJ; Mickelson JW; Milbank JB; Bove SE; Knauer CS; Brooker RM; Augelli-Szafran CE; Schwarz RD; Kinsora JJ; Kilgore KS
    Bioorg Med Chem Lett; 2007 Dec; 17(23):6525-8. PubMed ID: 17936624
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Dipyridyl amines: potent metabotropic glutamate subtype 5 receptor antagonists.
    Kamenecka TM; Bonnefous C; Govek S; Vernier JM; Hutchinson J; Chung J; Reyes-Manalo G; Anderson JJ
    Bioorg Med Chem Lett; 2005 Oct; 15(19):4350-3. PubMed ID: 16039855
    [TBL] [Abstract][Full Text] [Related]  

  • 4. In vitro and in vivo SAR of pyrido[3,4-d]pyramid-4-ylamine based mGluR1 antagonists.
    Mantell SJ; Gibson KR; Osborne SA; Maw GN; Rees H; Dodd PG; Greener B; Harbottle GW; Million WA; Poinsard C; England S; Carnell P; Betts AM; Monhemius R; Prime RL
    Bioorg Med Chem Lett; 2009 Apr; 19(8):2190-4. PubMed ID: 19289283
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Cyclohexenyl- and dehydropiperidinyl-alkynyl pyridines as potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists.
    Chua PC; Nagasawa JY; Bleicher LS; Munoz B; Schweiger EJ; Tehrani L; Anderson JJ; Cramer M; Chung J; Green MD; King CD; Reyes-Manalo G; Cosford ND
    Bioorg Med Chem Lett; 2005 Oct; 15(20):4589-93. PubMed ID: 16115767
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis and receptor assay of aromatic-ethynyl-aromatic derivatives with potent mGluR5 antagonist activity.
    Alagille D; Baldwin RM; Roth BL; Wroblewski JT; Grajkowska E; Tamagnan GD
    Bioorg Med Chem; 2005 Jan; 13(1):197-209. PubMed ID: 15582465
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Discovery and biological profile of 4-(1-aryltriazol-4-yl)-tetrahydropyridines as an orally active new class of metabotropic glutamate receptor 1 antagonist.
    Ito S; Satoh A; Nagatomi Y; Hirata Y; Suzuki G; Kimura T; Satow A; Maehara S; Hikichi H; Hata M; Kawamoto H; Ohta H
    Bioorg Med Chem; 2008 Nov; 16(22):9817-29. PubMed ID: 18849168
    [TBL] [Abstract][Full Text] [Related]  

  • 8. 3-[Substituted]-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitriles: identification of highly potent and selective metabotropic glutamate subtype 5 receptor antagonists.
    Tehrani LR; Smith ND; Huang D; Poon SF; Roppe JR; Seiders TJ; Chapman DF; Chung J; Cramer M; Cosford ND
    Bioorg Med Chem Lett; 2005 Nov; 15(22):5061-4. PubMed ID: 16183275
    [TBL] [Abstract][Full Text] [Related]  

  • 9. 2-Alkyl-4-aryl-pyrimidine fused heterocycles as selective 5-HT2A antagonists.
    Shireman BT; Dvorak CA; Rudolph DA; Bonaventure P; Nepomuceno D; Dvorak L; Miller KL; Lovenberg TW; Carruthers NI
    Bioorg Med Chem Lett; 2008 Mar; 18(6):2103-8. PubMed ID: 18282705
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists.
    Milbank JB; Knauer CS; Augelli-Szafran CE; Sakkab-Tan AT; Lin KK; Yamagata K; Hoffman JK; Zhuang N; Thomas J; Galatsis P; Wendt JA; Mickelson JW; Schwarz RD; Kinsora JJ; Lotarski SM; Stakich K; Gillespie KK; Lam WW; Mutlib AE
    Bioorg Med Chem Lett; 2007 Aug; 17(16):4415-8. PubMed ID: 17590335
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Discovery of molecular switches that modulate modes of metabotropic glutamate receptor subtype 5 (mGlu5) pharmacology in vitro and in vivo within a series of functionalized, regioisomeric 2- and 5-(phenylethynyl)pyrimidines.
    Sharma S; Kedrowski J; Rook JM; Smith RL; Jones CK; Rodriguez AL; Conn PJ; Lindsley CW
    J Med Chem; 2009 Jul; 52(14):4103-6. PubMed ID: 19537763
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Mutational analysis and molecular modeling of the binding pocket of the metabotropic glutamate 5 receptor negative modulator 2-methyl-6-(phenylethynyl)-pyridine.
    Malherbe P; Kratochwil N; Zenner MT; Piussi J; Diener C; Kratzeisen C; Fischer C; Porter RH
    Mol Pharmacol; 2003 Oct; 64(4):823-32. PubMed ID: 14500738
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists.
    Büttelmann B; Peters JU; Ceccarelli S; Kolczewski S; Vieira E; Prinssen EP; Spooren W; Schuler F; Huwyler J; Porter RH; Jaeschke G
    Bioorg Med Chem Lett; 2006 Apr; 16(7):1892-7. PubMed ID: 16439120
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Stereoselective synthesis and preliminary evaluation of (+)- and (-)-3-methyl-5-carboxy-thien-2-yl-glycine (3-MATIDA): identification of (+)-3-MATIDA as a novel mGluR1 competitive antagonist.
    Costantino G; Marinozzi M; Camaioni E; Natalini B; Sarichelou I; Micheli F; Cavanni P; Faedo S; Noe C; Moroni F; Pellicciari R
    Farmaco; 2004 Feb; 59(2):93-9. PubMed ID: 14871500
    [TBL] [Abstract][Full Text] [Related]  

  • 15. 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity.
    Cosford ND; Tehrani L; Roppe J; Schweiger E; Smith ND; Anderson J; Bristow L; Brodkin J; Jiang X; McDonald I; Rao S; Washburn M; Varney MA
    J Med Chem; 2003 Jan; 46(2):204-6. PubMed ID: 12519057
    [TBL] [Abstract][Full Text] [Related]  

  • 16. 5-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-2,3'-bipyridine: a highly potent, orally active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist with anxiolytic activity.
    Roppe JR; Wang B; Huang D; Tehrani L; Kamenecka T; Schweiger EJ; Anderson JJ; Brodkin J; Jiang X; Cramer M; Chung J; Reyes-Manalo G; Munoz B; Cosford ND
    Bioorg Med Chem Lett; 2004 Aug; 14(15):3993-6. PubMed ID: 15225713
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 5.
    Zhang P; Zou MF; Rodriguez AL; Conn PJ; Newman AH
    Bioorg Med Chem; 2010 May; 18(9):3026-35. PubMed ID: 20382541
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Design, synthesis and preliminary evaluation of novel 3'-substituted carboxycyclopropylglycines as antagonists at group 2 metabotropic glutamate receptors.
    Pellicciari R; Costantino G; Marinozzi M; Macchiarulo A; Amori L; Josef Flor P; Gasparini F; Kuhn R; Urwyler S
    Bioorg Med Chem Lett; 2001 Dec; 11(24):3179-82. PubMed ID: 11720869
    [TBL] [Abstract][Full Text] [Related]  

  • 19. 6-Aryl-3-pyrrolidinylpyridines as mGlu5 receptor negative allosteric modulators.
    Weiss JM; Jimenez HN; Li G; April M; Uberti MA; Bacolod MD; Brodbeck RM; Doller D
    Bioorg Med Chem Lett; 2011 Aug; 21(16):4891-9. PubMed ID: 21757343
    [TBL] [Abstract][Full Text] [Related]  

  • 20. 4-Aminopyrimidine tetrahydronaphthols: a series of novel vanilloid receptor-1 antagonists with improved solubility properties.
    Doherty EM; Retz D; Gavva NR; Tamir R; Treanor JJ; Norman MH
    Bioorg Med Chem Lett; 2008 Mar; 18(6):1830-4. PubMed ID: 18299195
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.