These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

238 related articles for article (PubMed ID: 17725339)

  • 1. Novel ATP-competitive kinesin spindle protein inhibitors.
    Parrish CA; Adams ND; Auger KR; Burgess JL; Carson JD; Chaudhari AM; Copeland RA; Diamond MA; Donatelli CA; Duffy KJ; Faucette LF; Finer JT; Huffman WF; Hugger ED; Jackson JR; Knight SD; Luo L; Moore ML; Newlander KA; Ridgers LH; Sakowicz R; Shaw AN; Sung CM; Sutton D; Wood KW; Zhang SY; Zimmerman MN; Dhanak D
    J Med Chem; 2007 Oct; 50(20):4939-52. PubMed ID: 17725339
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of novel spiro 1,3,4-thiadiazolines as potent, orally bioavailable and brain penetrant KSP inhibitors.
    Mansoor UF; Angeles AR; Dai C; Yang L; Vitharana D; Basso AD; Gray K; Tang H; Liu M; Liang L; Allbritton O; Siddiqui MA
    Bioorg Med Chem; 2015 May; 23(10):2424-34. PubMed ID: 25868746
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis and evaluation of biphenyl compounds as kinesin spindle protein inhibitors.
    Holland JP; Kang A; Cohrs S; Selivanova SV; Milicevic Sephton S; Betzel T; Frey D; Wieser M; Jaussi R; Kammerer RA; Schibli R; Fischer E
    Chem Biodivers; 2013 Apr; 10(4):538-55. PubMed ID: 23576341
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Kinesin spindle protein inhibitors in cancer: a patent review (2008 - present).
    Jiang C; You Q
    Expert Opin Ther Pat; 2013 Dec; 23(12):1547-60. PubMed ID: 23978071
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structure-activity relationships of carboline and carbazole derivatives as a novel class of ATP-competitive kinesin spindle protein inhibitors.
    Takeuchi T; Oishi S; Watanabe T; Ohno H; Sawada J; Matsuno K; Asai A; Asada N; Kitaura K; Fujii N
    J Med Chem; 2011 Jul; 54(13):4839-46. PubMed ID: 21599002
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Recent progress in the identification and clinical evaluation of inhibitors of the mitotic kinesin KSP.
    Knight SD; Parrish CA
    Curr Top Med Chem; 2008; 8(10):888-904. PubMed ID: 18673173
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis, biological evaluation and molecular docking studies of flavone and isoflavone derivatives as a novel class of KSP (kinesin spindle protein) inhibitors.
    Dong JJ; Li QS; Liu ZP; Wang SF; Zhao MY; Yang YH; Wang XM; Zhu HL
    Eur J Med Chem; 2013; 70():427-33. PubMed ID: 24184776
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery and biochemical characterization of selective ATP competitive inhibitors of the human mitotic kinesin KSP.
    Rickert KW; Schaber M; Torrent M; Neilson LA; Tasber ES; Garbaccio R; Coleman PJ; Harvey D; Zhang Y; Yang Y; Marshall G; Lee L; Walsh ES; Hamilton K; Buser CA
    Arch Biochem Biophys; 2008 Jan; 469(2):220-31. PubMed ID: 17999913
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Conformation-dependent ligand regulation of ATP hydrolysis by human KSP: activation of basal hydrolysis and inhibition of microtubule-stimulated hydrolysis by a single, small molecule modulator.
    Luo L; Carson JD; Molnar KS; Tuske SJ; Coales SJ; Hamuro Y; Sung CM; Sudakin V; Auger KR; Dhanak D; Jackson JR; Huang PS; Tummino PJ; Copeland RA
    J Am Chem Soc; 2008 Jun; 130(24):7584-91. PubMed ID: 18491908
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin KSP.
    Liu F; Yu LQ; Jiang C; Yang L; Wu WT; You QD
    Bioorg Med Chem; 2010 Jun; 18(12):4167-77. PubMed ID: 20537544
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Ligand- and structure-based in silico studies to identify kinesin spindle protein (KSP) inhibitors as potential anticancer agents.
    Balakumar C; Ramesh M; Tham CL; Khathi SP; Kozielski F; Srinivasulu C; Hampannavar GA; Sayyad N; Soliman ME; Karpoormath R
    J Biomol Struct Dyn; 2018 Nov; 36(14):3687-3704. PubMed ID: 29064326
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a kinesin spindle protein inhibitor and potential anticancer agent.
    Theoclitou ME; Aquila B; Block MH; Brassil PJ; Castriotta L; Code E; Collins MP; Davies AM; Deegan T; Ezhuthachan J; Filla S; Freed E; Hu H; Huszar D; Jayaraman M; Lawson D; Lewis PM; Nadella MV; Oza V; Padmanilayam M; Pontz T; Ronco L; Russell D; Whitston D; Zheng X
    J Med Chem; 2011 Oct; 54(19):6734-50. PubMed ID: 21899292
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Kinesin spindle protein (KSP) inhibitors in combination with chemotherapeutic agents for cancer therapy.
    Song H; Zhou S; Wang R; Li S
    ChemMedChem; 2013 Nov; 8(11):1736-49. PubMed ID: 23964020
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Antitumor activity of a kinesin inhibitor.
    Sakowicz R; Finer JT; Beraud C; Crompton A; Lewis E; Fritsch A; Lee Y; Mak J; Moody R; Turincio R; Chabala JC; Gonzales P; Roth S; Weitman S; Wood KW
    Cancer Res; 2004 May; 64(9):3276-80. PubMed ID: 15126370
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Novel benzimidazole inhibitors bind to a unique site in the kinesin spindle protein motor domain.
    Sheth PR; Shipps GW; Seghezzi W; Smith CK; Chuang CC; Sanden D; Basso AD; Vilenchik L; Gray K; Annis DA; Nickbarg E; Ma Y; Lahue B; Herbst R; Le HV
    Biochemistry; 2010 Sep; 49(38):8350-8. PubMed ID: 20718440
    [TBL] [Abstract][Full Text] [Related]  

  • 16. ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism.
    Luo L; Parrish CA; Nevins N; McNulty DE; Chaudhari AM; Carson JD; Sudakin V; Shaw AN; Lehr R; Zhao H; Sweitzer S; Lad L; Wood KW; Sakowicz R; Annan RS; Huang PS; Jackson JR; Dhanak D; Copeland RA; Auger KR
    Nat Chem Biol; 2007 Nov; 3(11):722-6. PubMed ID: 17922005
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structure-based design of new KSP-Eg5 inhibitors assisted by a targeted multicomponent reaction.
    Carbajales C; Prado MÁ; Gutiérrez-de-Terán H; Cores A; Azuaje J; Novio S; Nuñez MJ; Fernández-García B; Sotelo E; García-Mera X; Sánchez-Lazo P; Freire-Garabal M; Coelho A
    Chembiochem; 2014 Jul; 15(10):1471-80. PubMed ID: 24943831
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structural basis of new allosteric inhibition in Kinesin spindle protein Eg5.
    Yokoyama H; Sawada J; Katoh S; Matsuno K; Ogo N; Ishikawa Y; Hashimoto H; Fujii S; Asai A
    ACS Chem Biol; 2015 Apr; 10(4):1128-36. PubMed ID: 25622007
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Receptor-ligand interaction-based virtual screening for novel Eg5/kinesin spindle protein inhibitors.
    Nagarajan S; Skoufias DA; Kozielski F; Pae AN
    J Med Chem; 2012 Mar; 55(6):2561-73. PubMed ID: 22309208
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Mechanism of inhibition of human KSP by ispinesib.
    Lad L; Luo L; Carson JD; Wood KW; Hartman JJ; Copeland RA; Sakowicz R
    Biochemistry; 2008 Mar; 47(11):3576-85. PubMed ID: 18290633
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.