BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

448 related articles for article (PubMed ID: 17725983)

  • 1. Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content.
    De Vos KJ; Chapman AL; Tennant ME; Manser C; Tudor EL; Lau KF; Brownlees J; Ackerley S; Shaw PJ; McLoughlin DM; Shaw CE; Leigh PN; Miller CCJ; Grierson AJ
    Hum Mol Genet; 2007 Nov; 16(22):2720-2728. PubMed ID: 17725983
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Human Cu/Zn superoxide dismutase (SOD1) overexpression in mice causes mitochondrial vacuolization, axonal degeneration, and premature motoneuron death and accelerates motoneuron disease in mice expressing a familial amyotrophic lateral sclerosis mutant SOD1.
    Jaarsma D; Haasdijk ED; Grashorn JA; Hawkins R; van Duijn W; Verspaget HW; London J; Holstege JC
    Neurobiol Dis; 2000 Dec; 7(6 Pt B):623-43. PubMed ID: 11114261
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Amyotrophic lateral sclerosis-associated mutant SOD1 inhibits anterograde axonal transport of mitochondria by reducing Miro1 levels.
    Moller A; Bauer CS; Cohen RN; Webster CP; De Vos KJ
    Hum Mol Genet; 2017 Dec; 26(23):4668-4679. PubMed ID: 28973175
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Interaction between familial amyotrophic lateral sclerosis (ALS)-linked SOD1 mutants and the dynein complex.
    Zhang F; Ström AL; Fukada K; Lee S; Hayward LJ; Zhu H
    J Biol Chem; 2007 Jun; 282(22):16691-9. PubMed ID: 17403682
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Abnormal mitochondrial transport and morphology are common pathological denominators in SOD1 and TDP43 ALS mouse models.
    Magrané J; Cortez C; Gan WB; Manfredi G
    Hum Mol Genet; 2014 Mar; 23(6):1413-24. PubMed ID: 24154542
    [TBL] [Abstract][Full Text] [Related]  

  • 6. High-throughput quantitative analysis of axonal transport in cultured neurons from SOD1
    Otomo A; Ono S; Sato K; Mitsui S; Shimakura K; Kimura H; Hadano S
    Neurosci Res; 2022 Jan; 174():46-52. PubMed ID: 34352295
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Enhancing mitochondrial calcium buffering capacity reduces aggregation of misfolded SOD1 and motor neuron cell death without extending survival in mouse models of inherited amyotrophic lateral sclerosis.
    Parone PA; Da Cruz S; Han JS; McAlonis-Downes M; Vetto AP; Lee SK; Tseng E; Cleveland DW
    J Neurosci; 2013 Mar; 33(11):4657-71. PubMed ID: 23486940
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Mutant SOD1G93A triggers mitochondrial fragmentation in spinal cord motor neurons: neuroprotection by SIRT3 and PGC-1α.
    Song W; Song Y; Kincaid B; Bossy B; Bossy-Wetzel E
    Neurobiol Dis; 2013 Mar; 51():72-81. PubMed ID: 22819776
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Effects of ALS-related SOD1 mutants on dynein- and KIF5-mediated retrograde and anterograde axonal transport.
    Shi P; Ström AL; Gal J; Zhu H
    Biochim Biophys Acta; 2010 Sep; 1802(9):707-16. PubMed ID: 20510358
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mutant SOD1 in neuronal mitochondria causes toxicity and mitochondrial dynamics abnormalities.
    Magrané J; Hervias I; Henning MS; Damiano M; Kawamata H; Manfredi G
    Hum Mol Genet; 2009 Dec; 18(23):4552-64. PubMed ID: 19779023
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Impairment of axonal transport in the axon hillock and the initial segment of anterior horn neurons in transgenic mice with a G93A mutant SOD1 gene.
    Sasaki S; Warita H; Abe K; Iwata M
    Acta Neuropathol; 2005 Jul; 110(1):48-56. PubMed ID: 15920660
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons.
    Williamson TL; Cleveland DW
    Nat Neurosci; 1999 Jan; 2(1):50-6. PubMed ID: 10195180
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A mutation in dynein rescues axonal transport defects and extends the life span of ALS mice.
    Kieran D; Hafezparast M; Bohnert S; Dick JR; Martin J; Schiavo G; Fisher EM; Greensmith L
    J Cell Biol; 2005 May; 169(4):561-7. PubMed ID: 15911875
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Mitochondrial dynamics and bioenergetic dysfunction is associated with synaptic alterations in mutant SOD1 motor neurons.
    Magrané J; Sahawneh MA; Przedborski S; Estévez ÁG; Manfredi G
    J Neurosci; 2012 Jan; 32(1):229-42. PubMed ID: 22219285
    [TBL] [Abstract][Full Text] [Related]  

  • 15. CuZn superoxide dismutase (SOD1) accumulates in vacuolated mitochondria in transgenic mice expressing amyotrophic lateral sclerosis-linked SOD1 mutations.
    Jaarsma D; Rognoni F; van Duijn W; Verspaget HW; Haasdijk ED; Holstege JC
    Acta Neuropathol; 2001 Oct; 102(4):293-305. PubMed ID: 11603803
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Immunodetection of disease-associated conformers of mutant cu/zn superoxide dismutase 1 selectively expressed in degenerating neurons in amyotrophic lateral sclerosis.
    Sábado J; Casanovas A; Hernández S; Piedrafita L; Hereu M; Esquerda JE
    J Neuropathol Exp Neurol; 2013 Jul; 72(7):646-61. PubMed ID: 23771221
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Calcium-permeable AMPA receptors promote misfolding of mutant SOD1 protein and development of amyotrophic lateral sclerosis in a transgenic mouse model.
    Tateno M; Sadakata H; Tanaka M; Itohara S; Shin RM; Miura M; Masuda M; Aosaki T; Urushitani M; Misawa H; Takahashi R
    Hum Mol Genet; 2004 Oct; 13(19):2183-96. PubMed ID: 15294873
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Mitochondria-targeted catalase reverts the neurotoxicity of hSOD1G⁹³A astrocytes without extending the survival of ALS-linked mutant hSOD1 mice.
    Pehar M; Beeson G; Beeson CC; Johnson JA; Vargas MR
    PLoS One; 2014; 9(7):e103438. PubMed ID: 25054289
    [TBL] [Abstract][Full Text] [Related]  

  • 19. ALS-associated mutant SOD1G93A causes mitochondrial vacuolation by expansion of the intermembrane space and by involvement of SOD1 aggregation and peroxisomes.
    Higgins CM; Jung C; Xu Z
    BMC Neurosci; 2003 Jul; 4():16. PubMed ID: 12864925
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Mitochondrial dysfunction in familial amyotrophic lateral sclerosis.
    Faes L; Callewaert G
    J Bioenerg Biomembr; 2011 Dec; 43(6):587-92. PubMed ID: 22072073
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 23.