159 related articles for article (PubMed ID: 17764960)
1. Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists.
Asaki T; Hamamoto T; Sugiyama Y; Kuwano K; Kuwabara K
Bioorg Med Chem; 2007 Nov; 15(21):6692-704. PubMed ID: 17764960
[TBL] [Abstract][Full Text] [Related]
2. Structure-activity relationship study on the 6-membered heteroaromatic ring system of diphenylpyrazine-type prostacyclin receptor agonists.
Asaki T; Hamamoto T; Sugiyama Y; Kuwano K; Kuwabara K; Niwa T
Bioorg Med Chem Lett; 2007 Dec; 17(23):6588-92. PubMed ID: 17920266
[TBL] [Abstract][Full Text] [Related]
3. 2-[4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy]-N-(methylsulfonyl)acetamide (NS-304), an orally available and long-acting prostacyclin receptor agonist prodrug.
Kuwano K; Hashino A; Asaki T; Hamamoto T; Yamada T; Okubo K; Kuwabara K
J Pharmacol Exp Ther; 2007 Sep; 322(3):1181-8. PubMed ID: 17545310
[TBL] [Abstract][Full Text] [Related]
4. Synthesis and evaluation of N-acylsulfonamide and N-acylsulfonylurea prodrugs of a prostacyclin receptor agonist.
Nakamura A; Yamada T; Asaki T
Bioorg Med Chem; 2007 Dec; 15(24):7720-5. PubMed ID: 17881233
[TBL] [Abstract][Full Text] [Related]
5. Selexipag: An Oral and Selective IP Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension.
Asaki T; Kuwano K; Morrison K; Gatfield J; Hamamoto T; Clozel M
J Med Chem; 2015 Sep; 58(18):7128-37. PubMed ID: 26291199
[TBL] [Abstract][Full Text] [Related]
6. Development of dual-acting benzofurans for thromboxane A2 receptor antagonist and prostacyclin receptor agonist: synthesis, structure-activity relationship, and evaluation of benzofuran derivatives.
Ohno M; Miyamoto M; Hoshi K; Takeda T; Yamada N; Ohtake A
J Med Chem; 2005 Aug; 48(16):5279-94. PubMed ID: 16078846
[TBL] [Abstract][Full Text] [Related]
7. Synthesis of 2,6-diphenylpyrazine derivatives and their DNA binding and cytotoxic properties.
Dias N; Jacquemard U; Baldeyrou B; Lansiaux A; Goossens JF; Bailly C; Routier S; Mérour JY
Eur J Med Chem; 2005 Dec; 40(12):1206-13. PubMed ID: 16153749
[TBL] [Abstract][Full Text] [Related]
8. Synthesis and biological evaluation of novel hexahydro-pyrido[3',2':4,5]pyrrolo[1,2-a]pyrazines as potent and selective 5-HT(2C) receptor agonists.
Richter HG; Adams DR; Benardeau A; Bickerdike MJ; Bentley JM; Blench TJ; Cliffe IA; Dourish C; Hebeisen P; Kennett GA; Knight AR; Malcolm CS; Mattei P; Misra A; Mizrahi J; Monck NJ; Plancher JM; Roever S; Roffey JR; Taylor S; Vickers SP
Bioorg Med Chem Lett; 2006 Mar; 16(5):1207-11. PubMed ID: 16361098
[TBL] [Abstract][Full Text] [Related]
9. Scaffold hopping, synthesis and structure-activity relationships of 5,6-diaryl-pyrazine-2-amide derivatives: a novel series of CB1 receptor antagonists.
Boström J; Berggren K; Elebring T; Greasley PJ; Wilstermann M
Bioorg Med Chem; 2007 Jun; 15(12):4077-84. PubMed ID: 17433696
[TBL] [Abstract][Full Text] [Related]
10. Discovery of novel acetanilide derivatives as potent and selective beta3-adrenergic receptor agonists.
Maruyama T; Onda K; Hayakawa M; Matsui T; Takasu T; Ohta M
Eur J Med Chem; 2009 Jun; 44(6):2533-43. PubMed ID: 19232786
[TBL] [Abstract][Full Text] [Related]
11. Development of 3,4-dihydro-2H-benzo[1,4]oxazine derivatives as dual thromboxane A2 receptor antagonists and prostacyclin receptor agonists.
Ohno M; Tanaka Y; Miyamoto M; Takeda T; Hoshi K; Yamada N; Ohtake A
Bioorg Med Chem; 2006 Mar; 14(6):2005-21. PubMed ID: 16297632
[TBL] [Abstract][Full Text] [Related]
12. Structure-activity studies on 1,3-dioxane-2-carboxylic acid derivatives, a novel class of subtype-selective peroxisome proliferator-activated receptor alpha (PPARalpha) agonists.
Asaki T; Aoki T; Hamamoto T; Sugiyama Y; Ohmachi S; Kuwabara K; Murakami K; Todo M
Bioorg Med Chem; 2008 Jan; 16(2):981-94. PubMed ID: 17964792
[TBL] [Abstract][Full Text] [Related]
13. Synthesis and anti-mycobacterial evaluation of some pyrazine-2-carboxylic acid hydrazide derivatives.
Abdel-Aziz M; Abdel-Rahman HM
Eur J Med Chem; 2010 Aug; 45(8):3384-8. PubMed ID: 20488590
[TBL] [Abstract][Full Text] [Related]
14. Design and synthesis of substituted 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamides, novel HIV-1 integrase inhibitors.
Langford HM; Williams PD; Homnick CF; Vacca JP; Felock PJ; Stillmock KA; Witmer MV; Hazuda DJ; Gabryelski LJ; Schleif WA
Bioorg Med Chem Lett; 2008 Jan; 18(2):721-5. PubMed ID: 18078751
[TBL] [Abstract][Full Text] [Related]
15. Novel antagonists of serotonin-4 receptors: synthesis and biological evaluation of pyrrolothienopyrazines.
Lemaître S; Lepailleur A; Bureau R; Butt-Gueulle S; Lelong-Boulouard V; Duchatelle P; Boulouard M; Dumuis A; Daveu C; Lezoualc'h F; Pfeiffer B; Dauphin F; Rault S
Bioorg Med Chem; 2009 Mar; 17(6):2607-22. PubMed ID: 19261477
[TBL] [Abstract][Full Text] [Related]
16. Nonprostanoid prostacyclin mimetics. 5. Structure-activity relationships associated with [3-[4-(4,5-diphenyl-2-oxazolyl)-5- oxazolyl]phenoxy]acetic acid.
Meanwell NA; Romine JL; Rosenfeld MJ; Martin SW; Trehan AK; Wright JJ; Malley MF; Gougoutas JZ; Brassard CL; Buchanan JO
J Med Chem; 1993 Nov; 36(24):3884-903. PubMed ID: 7504734
[TBL] [Abstract][Full Text] [Related]
17. Synthesis of alkyne derivatives of a novel triazolopyrazine as A(2A) adenosine receptor antagonists.
Yao G; Haque S; Sha L; Kumaravel G; Wang J; Engber TM; Whalley ET; Conlon PR; Chang H; Kiesman WF; Petter RC
Bioorg Med Chem Lett; 2005 Feb; 15(3):511-5. PubMed ID: 15664803
[TBL] [Abstract][Full Text] [Related]
18. Ligustrazine derivatives. Part 3: Design, synthesis and evaluation of novel acylpiperazinyl derivatives as potential cerebrocardiac vascular agents.
Cheng XC; Liu XY; Xu WF; Guo XL; Zhang N; Song YN
Bioorg Med Chem; 2009 Apr; 17(8):3018-24. PubMed ID: 19329327
[TBL] [Abstract][Full Text] [Related]
19. Piperidine derivatives as nonprostanoid IP receptor agonists 2.
Hayashi R; Ito H; Ishigaki T; Morita Y; Miyamoto M; Isogaya M
Bioorg Med Chem Lett; 2016 Jun; 26(12):2886-2889. PubMed ID: 27133594
[TBL] [Abstract][Full Text] [Related]
20. Nonprostanoid prostacyclin mimetics. 4. Derivatives of 2-[3-[2-(4,5-diphenyl-2-oxazolyl)ethyl]phenoxy]acetic acid substituted alpha to the oxazole ring.
Meanwell NA; Rosenfeld MJ; Wright JJ; Brassard CL; Buchanan JO; Federici ME; Fleming JS; Gamberdella M; Hartl KS; Zavoico GB
J Med Chem; 1993 Nov; 36(24):3871-83. PubMed ID: 8254619
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
