115 related articles for article (PubMed ID: 1776875)
1. Cellular uptake of phosphonylmethoxyalkylpurine derivatives.
Palú G; Stefanelli S; Rassu M; Parolin C; Balzarini J; De Clercq E
Antiviral Res; 1991 Jul; 16(1):115-9. PubMed ID: 1776875
[TBL] [Abstract][Full Text] [Related]
2. Disposition of the acyclic nucleoside phosphonate (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine.
Bijsterbosch MK; Smeijsters LJ; van Berkel TJ
Antimicrob Agents Chemother; 1998 May; 42(5):1146-50. PubMed ID: 9593142
[TBL] [Abstract][Full Text] [Related]
3. Metabolic diversity and antiviral activities of acyclic nucleoside phosphonates.
Aduma P; Connelly MC; Srinivas RV; Fridland A
Mol Pharmacol; 1995 Apr; 47(4):816-22. PubMed ID: 7723743
[TBL] [Abstract][Full Text] [Related]
4. Selection and characterisation of murine leukaemia L1210 cells with high-level resistance to the cytostatic activity of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl) adenine (PMEA).
Balzarini J; Hatse S; Naesens L; De Clercq E
Biochim Biophys Acta; 1998 Mar; 1402(1):29-38. PubMed ID: 9551083
[TBL] [Abstract][Full Text] [Related]
5. Transport, uptake, and metabolism of the bis(pivaloyloxymethyl)-ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine in an in vitro cell culture system of the intestinal mucosa (Caco-2).
Annaert P; Kinget R; Naesens L; de Clercq E; Augustijns P
Pharm Res; 1997 Apr; 14(4):492-6. PubMed ID: 9144737
[TBL] [Abstract][Full Text] [Related]
6. Acyclic adenine nucleoside phosphonates in plasma determined by high-performance liquid chromatography with fluorescence detection.
Naesens L; Balzarini J; De Clercq E
Clin Chem; 1992 Apr; 38(4):480-5. PubMed ID: 1568310
[TBL] [Abstract][Full Text] [Related]
7. 5-Phosphoribosyl 1-pyrophosphate synthetase converts the acyclic nucleoside phosphonates 9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and 9-(2-phosphonylmethoxyethyl)adenine directly to their antivirally active diphosphate derivatives.
Balzarini J; De Clercq E
J Biol Chem; 1991 May; 266(14):8686-9. PubMed ID: 1851154
[TBL] [Abstract][Full Text] [Related]
8. Transport of 9-(2-phosphonomethoxyethyl)adenine across plasma membrane of HeLa S3 cells is protein mediated.
Cihlár T; Rosenberg I; Votruba I; Holý A
Antimicrob Agents Chemother; 1995 Jan; 39(1):117-24. PubMed ID: 7695292
[TBL] [Abstract][Full Text] [Related]
9. Pharmacokinetics of pradefovir and PMEA in healthy volunteers after oral dosing of pradefovir.
Lin CC; Xu C; Teng A; Yeh LT; Peterson J
J Clin Pharmacol; 2005 Nov; 45(11):1250-8. PubMed ID: 16239358
[TBL] [Abstract][Full Text] [Related]
10. Phosphorylation of acyclic nucleotide analogs HPMPA and PMEA in L1210 mouse leukemia cell extracts.
Merta A; Veselý J; Votruba I; Rosenberg I; Holý A
Neoplasma; 1990; 37(2):111-20. PubMed ID: 2160620
[TBL] [Abstract][Full Text] [Related]
11. Novel hepatotrophic prodrugs of the antiviral nucleoside 9-(2-phosphonylmethoxyethyl)adenine with improved pharmacokinetics and antiviral activity.
Biessen EA; Valentijn AR; De Vrueh RL; Van De Bilt E; Sliedregt LA; Prince P; Bijsterbosch MK; Van Boom JH; Van Der Marel GA; Abrahams PJ; Van Berkel TJ
FASEB J; 2000 Sep; 14(12):1784-92. PubMed ID: 10973928
[TBL] [Abstract][Full Text] [Related]
12. Human renal organic anion transporter 1 (hOAT1) and its role in the nephrotoxicity of antiviral nucleotide analogs.
Cihlar T; Ho ES; Lin DC; Mulato AS
Nucleosides Nucleotides Nucleic Acids; 2001; 20(4-7):641-8. PubMed ID: 11563082
[TBL] [Abstract][Full Text] [Related]
13. Cell-protecting effect against herpes simplex virus-1 and cellular metabolism of 9-(2-phosphonylmethoxyethyl)adenine in HeLa S3 cells.
Cerny J; Foster SA; Cheng YC
Mol Pharmacol; 1992 Sep; 42(3):537-44. PubMed ID: 1328849
[TBL] [Abstract][Full Text] [Related]
14. Phosphonylmethoxyalkyl derivatives of purine as inhibitors of human hepatitis B virus DNA synthesis.
Yokota T; Mochizuki S; Konno K; Mori S; Shigeta S; De Clercq E
Nucleic Acids Symp Ser; 1990; (22):17-8. PubMed ID: 2101900
[TBL] [Abstract][Full Text] [Related]
15. The cytostatic effects and mechanism of action of antiviral acyclic adenine nucleotide analogs in L1210 mouse leukemia cells.
Veselý J; Merta A; Votruba I; Rosenberg I; Holý A
Neoplasma; 1990; 37(2):105-10. PubMed ID: 2342627
[TBL] [Abstract][Full Text] [Related]
16. Comparison of the disposition of ester prodrugs of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine [PMEA] in Caco-2 monolayers.
Annaert P; Gosselin G; Pompon A; Benzaria S; Valette G; Imbach JL; Naesens L; Hatse S; de Clercq E; Van den Mooter G; Kinget R; Augustijns P
Pharm Res; 1998 Feb; 15(2):239-45. PubMed ID: 9523310
[TBL] [Abstract][Full Text] [Related]
17. Enhanced 9-(2-phosphonylmethoxyethyl)adenine secretion by a specific, indomethacin-sensitive efflux pump in a mutant 9-(2-phosphonylmethoxyethyl)adenine-resistant human erythroleukemia K562 cell line.
Hatse S; De Clercq E; Balzarini J
Mol Pharmacol; 1998 Nov; 54(5):907-17. PubMed ID: 9804626
[TBL] [Abstract][Full Text] [Related]
18. Mechanism of action of acyclic nucleoside phosphonates against herpes virus replication.
Neyts J; De Clercq E
Biochem Pharmacol; 1994 Jan; 47(1):39-41. PubMed ID: 8311844
[TBL] [Abstract][Full Text] [Related]
19. Phosphonylmethyl ethers of acyclic nucleoside analogues: inhibitors of HSV-1 induced ribonucleotide reductase.
Cerný J; Votruba I; Vonka V; Rosenberg I; Otmar M; Holý A
Antiviral Res; 1990 May; 13(5):253-64. PubMed ID: 2168691
[TBL] [Abstract][Full Text] [Related]
20. Chemotherapy of the acquired immune deficiency syndrome (AIDS): acyclic nucleoside phosphonate analogues.
De Clercq E
Int J Immunopharmacol; 1991; 13 Suppl 1():91-8. PubMed ID: 1823910
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]