BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

490 related articles for article (PubMed ID: 17785452)

  • 1. Different electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response.
    Tong KI; Padmanabhan B; Kobayashi A; Shang C; Hirotsu Y; Yokoyama S; Yamamoto M
    Mol Cell Biol; 2007 Nov; 27(21):7511-21. PubMed ID: 17785452
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model.
    Tong KI; Katoh Y; Kusunoki H; Itoh K; Tanaka T; Yamamoto M
    Mol Cell Biol; 2006 Apr; 26(8):2887-900. PubMed ID: 16581765
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome.
    Katoh Y; Iida K; Kang MI; Kobayashi A; Mizukami M; Tong KI; McMahon M; Hayes JD; Itoh K; Yamamoto M
    Arch Biochem Biophys; 2005 Jan; 433(2):342-50. PubMed ID: 15581590
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Kinetic, thermodynamic, and structural characterizations of the association between Nrf2-DLGex degron and Keap1.
    Fukutomi T; Takagi K; Mizushima T; Ohuchi N; Yamamoto M
    Mol Cell Biol; 2014 Mar; 34(5):832-46. PubMed ID: 24366543
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structural insights into the similar modes of Nrf2 transcription factor recognition by the cytoplasmic repressor Keap1.
    Padmanabhan B; Tong KI; Kobayashi A; Yamamoto M; Yokoyama S
    J Synchrotron Radiat; 2008 May; 15(Pt 3):273-6. PubMed ID: 18421157
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex.
    McMahon M; Thomas N; Itoh K; Yamamoto M; Hayes JD
    J Biol Chem; 2006 Aug; 281(34):24756-68. PubMed ID: 16790436
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structural analysis of the complex of Keap1 with a prothymosin alpha peptide.
    Padmanabhan B; Nakamura Y; Yokoyama S
    Acta Crystallogr Sect F Struct Biol Cryst Commun; 2008 Apr; 64(Pt 4):233-8. PubMed ID: 18391415
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy.
    Shibata T; Ohta T; Tong KI; Kokubu A; Odogawa R; Tsuta K; Asamura H; Yamamoto M; Hirohashi S
    Proc Natl Acad Sci U S A; 2008 Sep; 105(36):13568-73. PubMed ID: 18757741
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains.
    Ogura T; Tong KI; Mio K; Maruyama Y; Kurokawa H; Sato C; Yamamoto M
    Proc Natl Acad Sci U S A; 2010 Feb; 107(7):2842-7. PubMed ID: 20133743
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer.
    Padmanabhan B; Tong KI; Ohta T; Nakamura Y; Scharlock M; Ohtsuji M; Kang MI; Kobayashi A; Yokoyama S; Yamamoto M
    Mol Cell; 2006 Mar; 21(5):689-700. PubMed ID: 16507366
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Mathematical modeling reveals quantitative properties of KEAP1-NRF2 signaling.
    Liu S; Pi J; Zhang Q
    Redox Biol; 2021 Nov; 47():102139. PubMed ID: 34600335
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The Keap1-Nrf2 system as an in vivo sensor for electrophiles.
    Uruno A; Motohashi H
    Nitric Oxide; 2011 Aug; 25(2):153-60. PubMed ID: 21385624
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Kelch-like ECH-associated protein 1 (KEAP1) differentially regulates nuclear factor erythroid-2-related factors 1 and 2 (NRF1 and NRF2).
    Tian W; Rojo de la Vega M; Schmidlin CJ; Ooi A; Zhang DD
    J Biol Chem; 2018 Feb; 293(6):2029-2040. PubMed ID: 29255090
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron.
    McMahon M; Thomas N; Itoh K; Yamamoto M; Hayes JD
    J Biol Chem; 2004 Jul; 279(30):31556-67. PubMed ID: 15143058
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Keap1 degradation by autophagy for the maintenance of redox homeostasis.
    Taguchi K; Fujikawa N; Komatsu M; Ishii T; Unno M; Akaike T; Motohashi H; Yamamoto M
    Proc Natl Acad Sci U S A; 2012 Aug; 109(34):13561-6. PubMed ID: 22872865
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.
    Komatsu M; Kurokawa H; Waguri S; Taguchi K; Kobayashi A; Ichimura Y; Sou YS; Ueno I; Sakamoto A; Tong KI; Kim M; Nishito Y; Iemura S; Natsume T; Ueno T; Kominami E; Motohashi H; Tanaka K; Yamamoto M
    Nat Cell Biol; 2010 Mar; 12(3):213-23. PubMed ID: 20173742
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.
    Zhang DD; Lo SC; Cross JV; Templeton DJ; Hannink M
    Mol Cell Biol; 2004 Dec; 24(24):10941-53. PubMed ID: 15572695
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination.
    Hast BE; Goldfarb D; Mulvaney KM; Hast MA; Siesser PF; Yan F; Hayes DN; Major MB
    Cancer Res; 2013 Apr; 73(7):2199-210. PubMed ID: 23382044
    [TBL] [Abstract][Full Text] [Related]  

  • 19. p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription.
    Jain A; Lamark T; Sjøttem E; Larsen KB; Awuh JA; Øvervatn A; McMahon M; Hayes JD; Johansen T
    J Biol Chem; 2010 Jul; 285(29):22576-91. PubMed ID: 20452972
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.
    Ichimura Y; Waguri S; Sou YS; Kageyama S; Hasegawa J; Ishimura R; Saito T; Yang Y; Kouno T; Fukutomi T; Hoshii T; Hirao A; Takagi K; Mizushima T; Motohashi H; Lee MS; Yoshimori T; Tanaka K; Yamamoto M; Komatsu M
    Mol Cell; 2013 Sep; 51(5):618-31. PubMed ID: 24011591
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 25.