BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

196 related articles for article (PubMed ID: 17827007)

  • 21. Synthesis, topoisomerase I inhibition and structure-activity relationship study of 2,4,6-trisubstituted pyridine derivatives.
    Zhao LX; Moon YS; Basnet A; Kim EK; Jahng Y; Park JG; Jeong TC; Cho WJ; Choi SU; Lee CO; Lee SY; Lee CS; Lee ES
    Bioorg Med Chem Lett; 2004 Mar; 14(5):1333-7. PubMed ID: 14980693
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Novel synthetic isoquinolino[5,4-ab]phenazines: inhibition toward topoisomerase I, antitumor and DNA photo-cleaving activities.
    Yang P; Yang Q; Qian X; Cui J
    Bioorg Med Chem; 2005 Nov; 13(21):5909-14. PubMed ID: 16115776
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Modification of 3-arylisoquinolines into 3,4-diarylisoquinolines and assessment of their cytotoxicity and topoisomerase inhibition.
    Khadka DB; Woo H; Yang SH; Zhao C; Jin Y; Le TN; Kwon Y; Cho WJ
    Eur J Med Chem; 2015 Mar; 92():583-607. PubMed ID: 25613224
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Synthesis and structure-activity relationships of new benzodioxinic lactones as potential anticancer drugs.
    Romero M; Renard P; Caignard DH; Atassi G; Solans X; Constans P; Bailly C; Pujol MD
    J Med Chem; 2007 Jan; 50(2):294-307. PubMed ID: 17228871
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Synthesis, cytotoxic activities and structure-activity relationships of topoisomerase I inhibitors: indolizinoquinoline-5,12-dione derivatives.
    Cheng Y; An LK; Wu N; Wang XD; Bu XZ; Huang ZS; Gu LQ
    Bioorg Med Chem; 2008 Apr; 16(8):4617-25. PubMed ID: 18296054
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Evaluation of indenoisoquinoline topoisomerase I inhibitors using a hollow fiber assay.
    Morrell A; Jayaraman M; Nagarajan M; Fox BM; Meckley MR; Ioanoviciu A; Pommier Y; Antony S; Hollingshead M; Cushman M
    Bioorg Med Chem Lett; 2006 Aug; 16(16):4395-9. PubMed ID: 16750365
    [TBL] [Abstract][Full Text] [Related]  

  • 27. 6-Substituted 6H-dibenzo[c,h][2,6]naphthyridin-5-ones: reversed lactam analogues of ARC-111 with potent topoisomerase I-targeting activity and cytotoxicity.
    Zhu S; Ruchelman AL; Zhou N; Liu A; Liu LF; LaVoie EJ
    Bioorg Med Chem; 2006 May; 14(9):3131-43. PubMed ID: 16412652
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Exploring DNA topoisomerase I inhibition by the benzo[c]phenanthridines fagaronine and ethoxidine using steered molecular dynamics.
    Clark RL; Deane FM; Anthony NG; Johnston BF; McCarthy FO; Mackay SP
    Bioorg Med Chem; 2007 Jul; 15(14):4741-52. PubMed ID: 17517513
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Synthesis of benz[d]indeno[1,2-b]pyran-5,11-diones: versatile intermediates for the design and synthesis of topoisomerase I inhibitors.
    Morrell A; Antony S; Kohlhagen G; Pommier Y; Cushman M
    Bioorg Med Chem Lett; 2006 Apr; 16(7):1846-9. PubMed ID: 16442283
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Synthesis and cytotoxic activity of a new series of topoisomerase I inhibitors.
    Dallavalle S; Gattinoni S; Mazzini S; Scaglioni L; Merlini L; Tinelli S; Beretta GL; Zunino F
    Bioorg Med Chem Lett; 2008 Feb; 18(4):1484-9. PubMed ID: 18248813
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (2).
    Asano Y; Kitamura S; Ohra T; Itoh F; Kajino M; Tamura T; Kaneko M; Ikeda S; Igata H; Kawamoto T; Sogabe S; Matsumoto S; Tanaka T; Yamaguchi M; Kimura H; Fukumoto S
    Bioorg Med Chem; 2008 Apr; 16(8):4699-714. PubMed ID: 18313930
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Synthesis and biological activity of ferrocenyl indeno[1,2-c]isoquinolines as topoisomerase II inhibitors.
    Wambang N; Schifano-Faux N; Aillerie A; Baldeyrou B; Jacquet C; Bal-Mahieu C; Bousquet T; Pellegrini S; Ndifon PT; Meignan S; Goossens JF; Lansiaux A; PĂ©linski L
    Bioorg Med Chem; 2016 Feb; 24(4):651-60. PubMed ID: 26740155
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Synthesis and biological evaluation of bisindenoisoquinolines as topoisomerase I inhibitors.
    Nagarajan M; Morrell A; Antony S; Kohlhagen G; Agama K; Pommier Y; Ragazzon PA; Garbett NC; Chaires JB; Hollingshead M; Cushman M
    J Med Chem; 2006 Aug; 49(17):5129-40. PubMed ID: 16913702
    [TBL] [Abstract][Full Text] [Related]  

  • 34. On the binding of indeno[1,2-c]isoquinolines in the DNA-topoisomerase I cleavage complex.
    Xiao X; Antony S; Pommier Y; Cushman M
    J Med Chem; 2005 May; 48(9):3231-8. PubMed ID: 15857129
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (1).
    Asano Y; Kitamura S; Ohra T; Aso K; Igata H; Tamura T; Kawamoto T; Tanaka T; Sogabe S; Matsumoto S; Yamaguchi M; Kimura H; Itoh F
    Bioorg Med Chem; 2008 Apr; 16(8):4715-32. PubMed ID: 18313304
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Natural inhibitors of DNA topoisomerase I with cytotoxicities.
    Han HJ; Tan NH; Zeng GZ; Fan JT; Huang HQ; Ji CJ; Jia RR; Zhao QS; Zhang YJ; Hao XJ; Wang LQ
    Chem Biodivers; 2008 Jul; 5(7):1364-8. PubMed ID: 18649302
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Cellular topoisomerase I inhibition and antiproliferative activity by MJ-III-65 (NSC 706744), an indenoisoquinoline topoisomerase I poison.
    Antony S; Kohlhagen G; Agama K; Jayaraman M; Cao S; Durrani FA; Rustum YM; Cushman M; Pommier Y
    Mol Pharmacol; 2005 Feb; 67(2):523-30. PubMed ID: 15531731
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Design and synthesis of N-methylmaleimide indolocarbazole bearing modified 2-acetamino acid moieties as Topoisomerase I inhibitors.
    Li Z; Zhai F; Zhao L; Guo Q; You Q
    Bioorg Med Chem Lett; 2009 Jan; 19(2):406-9. PubMed ID: 19058964
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Indeno[1,2-c]isoquinolin-5,11-diones conjugated to amino acids: Synthesis, cytotoxicity, DNA interaction, and topoisomerase II inhibition properties.
    Ahn G; Lansiaux A; Goossens JF; Bailly C; Baldeyrou B; Schifano-Faux N; Grandclaudon P; Couture A; Ryckebusch A
    Bioorg Med Chem; 2010 Nov; 18(22):8119-33. PubMed ID: 20961767
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Benzothiopyranoindole-based antiproliferative agents: synthesis, cytotoxicity, nucleic acids interaction, and topoisomerases inhibition properties.
    Dalla Via L; Magno SM; Gia O; Marini AM; Da Settimo F; Salerno S; La Motta C; Simorini F; Taliani S; Lavecchia A; Di Giovanni C; Brancato G; Barone V; Novellino E
    J Med Chem; 2009 Sep; 52(17):5429-41. PubMed ID: 19725581
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 10.