BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

170 related articles for article (PubMed ID: 17828303)

  • 1. SAG/ROC2/RBX2 is a HIF-1 target gene that promotes HIF-1 alpha ubiquitination and degradation.
    Tan M; Gu Q; He H; Pamarthy D; Semenza GL; Sun Y
    Oncogene; 2008 Feb; 27(10):1404-11. PubMed ID: 17828303
    [TBL] [Abstract][Full Text] [Related]  

  • 2. SAG/ROC-SCF beta-TrCP E3 ubiquitin ligase promotes pro-caspase-3 degradation as a mechanism of apoptosis protection.
    Tan M; Gallegos JR; Gu Q; Huang Y; Li J; Jin Y; Lu H; Sun Y
    Neoplasia; 2006 Dec; 8(12):1042-54. PubMed ID: 17217622
    [TBL] [Abstract][Full Text] [Related]  

  • 3. SAG/ROC2/Rbx2 is a novel activator protein-1 target that promotes c-Jun degradation and inhibits 12-O-tetradecanoylphorbol-13-acetate-induced neoplastic transformation.
    Gu Q; Tan M; Sun Y
    Cancer Res; 2007 Apr; 67(8):3616-25. PubMed ID: 17440073
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The pVHL-associated SCF ubiquitin ligase complex: molecular genetic analysis of elongin B and C, Rbx1 and HIF-1alpha in renal cell carcinoma.
    Clifford SC; Astuti D; Hooper L; Maxwell PH; Ratcliffe PJ; Maher ER
    Oncogene; 2001 Aug; 20(36):5067-74. PubMed ID: 11526493
    [TBL] [Abstract][Full Text] [Related]  

  • 5. HIF-1alpha and EPAS ubiquitination mediated by the VHL tumour suppressor involves flexibility in the ubiquitination mechanism, similar to other RING E3 ligases.
    Paltoglou S; Roberts BJ
    Oncogene; 2007 Jan; 26(4):604-9. PubMed ID: 16862177
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function.
    Krieg M; Haas R; Brauch H; Acker T; Flamme I; Plate KH
    Oncogene; 2000 Nov; 19(48):5435-43. PubMed ID: 11114720
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors.
    Aprelikova O; Chandramouli GV; Wood M; Vasselli JR; Riss J; Maranchie JK; Linehan WM; Barrett JC
    J Cell Biochem; 2004 Jun; 92(3):491-501. PubMed ID: 15156561
    [TBL] [Abstract][Full Text] [Related]  

  • 8. SAG/ROC2/Rbx2/Hrt2, a component of SCF E3 ubiquitin ligase: genomic structure, a splicing variant, and two family pseudogenes.
    Swaroop M; Gosink M; Sun Y
    DNA Cell Biol; 2001 Jul; 20(7):425-34. PubMed ID: 11506706
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Functional characterization of SAG/RBX2/ROC2/RNF7, an antioxidant protein and an E3 ubiquitin ligase.
    Sun Y; Li H
    Protein Cell; 2013 Feb; 4(2):103-16. PubMed ID: 23136067
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3'-kinase/Akt signaling pathway.
    Blancher C; Moore JW; Robertson N; Harris AL
    Cancer Res; 2001 Oct; 61(19):7349-55. PubMed ID: 11585776
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Role of the von Hippel-Lindau tumour suppressor protein in the regulation of HIF-1alpha and its oxygen-regulated transactivation domains at high cell density.
    Paltoglou SM; Roberts BJ
    Oncogene; 2005 May; 24(23):3830-5. PubMed ID: 15750626
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Dynamic, site-specific interaction of hypoxia-inducible factor-1alpha with the von Hippel-Lindau tumor suppressor protein.
    Yu F; White SB; Zhao Q; Lee FS
    Cancer Res; 2001 May; 61(10):4136-42. PubMed ID: 11358837
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein.
    Tanimoto K; Makino Y; Pereira T; Poellinger L
    EMBO J; 2000 Aug; 19(16):4298-309. PubMed ID: 10944113
    [TBL] [Abstract][Full Text] [Related]  

  • 14. RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha.
    Liu YV; Baek JH; Zhang H; Diez R; Cole RN; Semenza GL
    Mol Cell; 2007 Jan; 25(2):207-17. PubMed ID: 17244529
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Role of the C-terminal alpha-helical domain of the von Hippel-Lindau protein in its E3 ubiquitin ligase activity.
    Lewis MD; Roberts BJ
    Oncogene; 2004 Mar; 23(13):2315-23. PubMed ID: 14691445
    [TBL] [Abstract][Full Text] [Related]  

  • 16. RACK1 vs. HSP90: competition for HIF-1 alpha degradation vs. stabilization.
    Liu YV; Semenza GL
    Cell Cycle; 2007 Mar; 6(6):656-9. PubMed ID: 17361105
    [TBL] [Abstract][Full Text] [Related]  

  • 17. VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.
    Kamura T; Maenaka K; Kotoshiba S; Matsumoto M; Kohda D; Conaway RC; Conaway JW; Nakayama KI
    Genes Dev; 2004 Dec; 18(24):3055-65. PubMed ID: 15601820
    [TBL] [Abstract][Full Text] [Related]  

  • 18. SAG/RBX2 is a novel substrate of NEDD4-1 E3 ubiquitin ligase and mediates NEDD4-1 induced chemosensitization.
    Zhou W; Xu J; Zhao Y; Sun Y
    Oncotarget; 2014 Aug; 5(16):6746-55. PubMed ID: 25216516
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1alpha in clear cell renal carcinomas.
    Wiesener MS; Münchenhagen PM; Berger I; Morgan NV; Roigas J; Schwiertz A; Jürgensen JS; Gruber G; Maxwell PH; Löning SA; Frei U; Maher ER; Gröne HJ; Eckardt KU
    Cancer Res; 2001 Jul; 61(13):5215-22. PubMed ID: 11431362
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha.
    Baek JH; Liu YV; McDonald KR; Wesley JB; Zhang H; Semenza GL
    J Biol Chem; 2007 Nov; 282(46):33358-33366. PubMed ID: 17875644
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.