BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

160 related articles for article (PubMed ID: 17848562)

  • 1. Kinetic mechanism of human dUTPase, an essential nucleotide pyrophosphatase enzyme.
    Tóth J; Varga B; Kovács M; Málnási-Csizmadia A; Vértessy BG
    J Biol Chem; 2007 Nov; 282(46):33572-33582. PubMed ID: 17848562
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Methylene substitution at the alpha-beta bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site.
    Kovári J; Barabás O; Varga B; Békési A; Tölgyesi F; Fidy J; Nagy J; Vértessy BG
    Proteins; 2008 Apr; 71(1):308-19. PubMed ID: 17932923
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structure/function analysis of a dUTPase: catalytic mechanism of a potential chemotherapeutic target.
    Harris JM; McIntosh EM; Muscat GE
    J Mol Biol; 1999 Apr; 288(2):275-87. PubMed ID: 10329142
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Human dUTP pyrophosphatase: uracil recognition by a beta hairpin and active sites formed by three separate subunits.
    Mol CD; Harris JM; McIntosh EM; Tainer JA
    Structure; 1996 Sep; 4(9):1077-92. PubMed ID: 8805593
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structural insights into the catalytic mechanism of phosphate ester hydrolysis by dUTPase.
    Barabás O; Pongrácz V; Kovári J; Wilmanns M; Vértessy BG
    J Biol Chem; 2004 Oct; 279(41):42907-15. PubMed ID: 15208312
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Concerted bifunctionality of the dCTP deaminase-dUTPase from Methanocaldococcus jannaschii: a structural and pre-steady state kinetic analysis.
    Siggaard JH; Johansson E; Vognsen T; Helt SS; Harris P; Larsen S; Willemoës M
    Arch Biochem Biophys; 2009 Oct; 490(1):42-9. PubMed ID: 19683509
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Multidimensional NMR identifies the conformational shift essential for catalytic competence in the 60-kDa Drosophila melanogaster dUTPase trimer.
    Dubrovay Z; Gáspári Z; Hunyadi-Gulyás E; Medzihradszky KF; Perczel A; Vértessy BG
    J Biol Chem; 2004 Apr; 279(17):17945-50. PubMed ID: 14724273
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Nucleotide pyrophosphatase employs a P-loop-like motif to enhance catalytic power and NDP/NTP discrimination.
    Pécsi I; Szabó JE; Adams SD; Simon I; Sellers JR; Vértessy BG; Tóth J
    Proc Natl Acad Sci U S A; 2011 Aug; 108(35):14437-42. PubMed ID: 21831832
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Active site closure facilitates juxtaposition of reactant atoms for initiation of catalysis by human dUTPase.
    Varga B; Barabás O; Kovári J; Tóth J; Hunyadi-Gulyás E; Klement E; Medzihradszky KF; Tölgyesi F; Fidy J; Vértessy BG
    FEBS Lett; 2007 Oct; 581(24):4783-8. PubMed ID: 17880943
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Altered active site flexibility and a structural metal-binding site in eukaryotic dUTPase: kinetic characterization, folding, and crystallographic studies of the homotrimeric Drosophila enzyme.
    Kovári J; Barabás O; Takács E; Békési A; Dubrovay Z; Pongrácz V; Zagyva I; Imre T; Szabó P; Vértessy BG
    J Biol Chem; 2004 Apr; 279(17):17932-44. PubMed ID: 14724274
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Kinetic characterization of dUTPase from Escherichia coli.
    Larsson G; Nyman PO; Kvassman JO
    J Biol Chem; 1996 Sep; 271(39):24010-6. PubMed ID: 8798636
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structural basis for recognition and catalysis by the bifunctional dCTP deaminase and dUTPase from Methanococcus jannaschii.
    Huffman JL; Li H; White RH; Tainer JA
    J Mol Biol; 2003 Aug; 331(4):885-96. PubMed ID: 12909016
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Catalytic and structural role of the metal ion in dUTP pyrophosphatase.
    Mustafi D; Bekesi A; Vertessy BG; Makinen MW
    Proc Natl Acad Sci U S A; 2003 May; 100(10):5670-5. PubMed ID: 12721364
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structural insights into the mechanism defining substrate affinity in Arabidopsis thaliana dUTPase: the role of tryptophan 93 in ligand orientation.
    Inoguchi N; Chaiseeda K; Yamanishi M; Kim MK; Jang Y; Bajaj M; Chia CP; Becker DF; Moriyama H
    BMC Res Notes; 2015 Dec; 8():784. PubMed ID: 26666293
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The flexible motif V of Epstein-Barr virus deoxyuridine 5'-triphosphate pyrophosphatase is essential for catalysis.
    Freeman L; Buisson M; Tarbouriech N; Van der Heyden A; Labbé P; Burmeister WP
    J Biol Chem; 2009 Sep; 284(37):25280-9. PubMed ID: 19586911
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Active site of mycobacterial dUTPase: structural characteristics and a built-in sensor.
    Varga B; Barabás O; Takács E; Nagy N; Nagy P; Vértessy BG
    Biochem Biophys Res Commun; 2008 Aug; 373(1):8-13. PubMed ID: 18519027
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The complete triphosphate moiety of non-hydrolyzable substrate analogues is required for a conformational shift of the flexible C-terminus in E. coli dUTP pyrophosphatase.
    Vertessy BG; Larsson G; Persson T; Bergman AC; Persson R; Nyman PO
    FEBS Lett; 1998 Jan; 421(1):83-8. PubMed ID: 9462846
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A double role for a strictly conserved serine: further insights into the dUTPase catalytic mechanism.
    Palmén LG; Becker K; Bülow L; Kvassman JO
    Biochemistry; 2008 Jul; 47(30):7863-74. PubMed ID: 18597482
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structures of vaccinia virus dUTPase and its nucleotide complexes.
    Samal A; Schormann N; Cook WJ; DeLucas LJ; Chattopadhyay D
    Acta Crystallogr D Biol Crystallogr; 2007 May; 63(Pt 5):571-80. PubMed ID: 17452782
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Enzyme kinetics of dUTPase from the planarian Dugesia ryukyuensis.
    Alam MS; Moriyama H; Matsumoto M
    BMC Res Notes; 2019 Mar; 12(1):163. PubMed ID: 30902068
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.