154 related articles for article (PubMed ID: 17848571)
1. Elucidation of a complete kinetic mechanism for a mammalian hydroxysteroid dehydrogenase (HSD) and identification of all enzyme forms on the reaction coordinate: the example of rat liver 3alpha-HSD (AKR1C9).
Cooper WC; Jin Y; Penning TM
J Biol Chem; 2007 Nov; 282(46):33484-33493. PubMed ID: 17848571
[TBL] [Abstract][Full Text] [Related]
2. Dissection of the physiological interconversion of 5alpha-DHT and 3alpha-diol by rat 3alpha-HSD via transient kinetics shows that the chemical step is rate-determining: effect of mutating cofactor and substrate-binding pocket residues on catalysis.
Heredia VV; Penning TM
Biochemistry; 2004 Sep; 43(38):12028-37. PubMed ID: 15379543
[TBL] [Abstract][Full Text] [Related]
3. Alanine scanning mutagenesis of the testosterone binding site of rat 3 alpha-hydroxysteroid dehydrogenase demonstrates contact residues influence the rate-determining step.
Heredia VV; Cooper WC; Kruger RG; Jin Y; Penning TM
Biochemistry; 2004 May; 43(19):5832-41. PubMed ID: 15134457
[TBL] [Abstract][Full Text] [Related]
4. Steroid-binding site residues dictate optimal substrate positioning in rat 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD or AKR1C9).
Heredia VV; Kruger RG; Penning TM
Chem Biol Interact; 2003 Feb; 143-144():393-400. PubMed ID: 12604226
[TBL] [Abstract][Full Text] [Related]
5. Examination of the differences in structure-function of human and rat 3alpha-hydroxysteroid dehydrogenase.
Jin Y; Cooper WC; Penning TM
Chem Biol Interact; 2003 Feb; 143-144():383-92. PubMed ID: 12604225
[TBL] [Abstract][Full Text] [Related]
6. Multiple steps determine the overall rate of the reduction of 5alpha-dihydrotestosterone catalyzed by human type 3 3alpha-hydroxysteroid dehydrogenase: implications for the elimination of androgens.
Jin Y; Penning TM
Biochemistry; 2006 Oct; 45(43):13054-63. PubMed ID: 17059222
[TBL] [Abstract][Full Text] [Related]
7. Structure-function relationships in 3alpha-hydroxysteroid dehydrogenases: a comparison of the rat and human isoforms.
Penning TM; Jin Y; Heredia VV; Lewis M
J Steroid Biochem Mol Biol; 2003 Jun; 85(2-5):247-55. PubMed ID: 12943710
[TBL] [Abstract][Full Text] [Related]
8. Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones.
Penning TM; Burczynski ME; Jez JM; Hung CF; Lin HK; Ma H; Moore M; Palackal N; Ratnam K
Biochem J; 2000 Oct; 351(Pt 1):67-77. PubMed ID: 10998348
[TBL] [Abstract][Full Text] [Related]
9. The arginine 276 anchor for NADP(H) dictates fluorescence kinetic transients in 3 alpha-hydroxysteroid dehydrogenase, a representative aldo-keto reductase.
Ratnam K; Ma H; Penning TM
Biochemistry; 1999 Jun; 38(24):7856-64. PubMed ID: 10387026
[TBL] [Abstract][Full Text] [Related]
10. Structure-function aspects and inhibitor design of type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3).
Penning TM; Burczynski ME; Jez JM; Lin HK; Ma H; Moore M; Ratnam K; Palackal N
Mol Cell Endocrinol; 2001 Jan; 171(1-2):137-49. PubMed ID: 11165022
[TBL] [Abstract][Full Text] [Related]
11. Engineering steroid hormone specificity into aldo-keto reductases.
Penning TM; Ma H; Jez JM
Chem Biol Interact; 2001 Jan; 130-132(1-3):659-71. PubMed ID: 11306084
[TBL] [Abstract][Full Text] [Related]
12. Structure and function of 3 alpha-hydroxysteroid dehydrogenase.
Penning TM; Bennett MJ; Smith-Hoog S; Schlegel BP; Jez JM; Lewis M
Steroids; 1997 Jan; 62(1):101-11. PubMed ID: 9029723
[TBL] [Abstract][Full Text] [Related]
13. Steroid recognition and regulation of hormone action: crystal structure of testosterone and NADP+ bound to 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase.
Bennett MJ; Albert RH; Jez JM; Ma H; Penning TM; Lewis M
Structure; 1997 Jun; 5(6):799-812. PubMed ID: 9261071
[TBL] [Abstract][Full Text] [Related]
14. Mutation of nicotinamide pocket residues in rat liver 3 alpha-hydroxysteroid dehydrogenase reveals different modes of cofactor binding.
Ma H; Ratnam K; Penning TM
Biochemistry; 2000 Jan; 39(1):102-9. PubMed ID: 10625484
[TBL] [Abstract][Full Text] [Related]
15. Rat NAD+-dependent 3alpha-hydroxysteroid dehydrogenase (AKR1C17): a member of the aldo-keto reductase family highly expressed in kidney cytosol.
Sanai M; Endo S; Matsunaga T; Ishikura S; Tajima K; El-Kabbani O; Hara A
Arch Biochem Biophys; 2007 Aug; 464(1):122-9. PubMed ID: 17475203
[TBL] [Abstract][Full Text] [Related]
16. Contribution of remote substrate binding energy to the enzymatic rate acceleration for 3α-hydroxysteroid dehydrogenase/carbonyl reductase.
Hwang CC; Chang PR; Wang TP
Chem Biol Interact; 2017 Oct; 276():133-140. PubMed ID: 28137513
[TBL] [Abstract][Full Text] [Related]
17. Transient-phase kinetic studies on the nucleotide binding to 3alpha-hydroxysteroid dehydrogenase from Pseudomonas sp. B-0831 using fluorescence stopped-flow procedures.
Ueda S; Oda M; Imamura S; Ohnishi M
Eur J Biochem; 2004 May; 271(9):1774-80. PubMed ID: 15096216
[TBL] [Abstract][Full Text] [Related]
18. Conversion of mammalian 3alpha-hydroxysteroid dehydrogenase to 20alpha-hydroxysteroid dehydrogenase using loop chimeras: changing specificity from androgens to progestins.
Ma H; Penning TM
Proc Natl Acad Sci U S A; 1999 Sep; 96(20):11161-6. PubMed ID: 10500147
[TBL] [Abstract][Full Text] [Related]
19. Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action.
Steckelbroeck S; Jin Y; Gopishetty S; Oyesanmi B; Penning TM
J Biol Chem; 2004 Mar; 279(11):10784-95. PubMed ID: 14672942
[TBL] [Abstract][Full Text] [Related]
20. Characterization of the substrate binding site in rat liver 3alpha-hydroxysteroid/dihydrodiol dehydrogenase. The roles of tryptophans in ligand binding and protein fluorescence.
Jez JM; Schlegel BP; Penning TM
J Biol Chem; 1996 Nov; 271(47):30190-8. PubMed ID: 8939970
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]