BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

171 related articles for article (PubMed ID: 17867646)

  • 1. Identification of cytochrome P450 3A4 modification site with reactive metabolite using linear ion trap-Fourier transform mass spectrometry.
    Yukinaga H; Takami T; Shioyama SH; Tozuka Z; Masumoto H; Okazaki O; Sudo K
    Chem Res Toxicol; 2007 Oct; 20(10):1373-8. PubMed ID: 17867646
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Time-dependent inactivation of P450 3A4 by raloxifene: identification of Cys239 as the site of apoprotein alkylation.
    Baer BR; Wienkers LC; Rock DA
    Chem Res Toxicol; 2007 Jun; 20(6):954-64. PubMed ID: 17497897
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Cytochrome P450 3A4-mediated bioactivation of raloxifene: irreversible enzyme inhibition and thiol adduct formation.
    Chen Q; Ngui JS; Doss GA; Wang RW; Cai X; DiNinno FP; Blizzard TA; Hammond ML; Stearns RA; Evans DC; Baillie TA; Tang W
    Chem Res Toxicol; 2002 Jul; 15(7):907-14. PubMed ID: 12119000
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mechanism-based inactivation of cytochrome P450 3A4 by 17 alpha-ethynylestradiol: evidence for heme destruction and covalent binding to protein.
    Lin HL; Kent UM; Hollenberg PF
    J Pharmacol Exp Ther; 2002 Apr; 301(1):160-7. PubMed ID: 11907170
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Mechanism-based inactivation of cytochrome P450 3A4 by L-754,394.
    Lightning LK; Jones JP; Friedberg T; Pritchard MP; Shou M; Rushmore TH; Trager WF
    Biochemistry; 2000 Apr; 39(15):4276-87. PubMed ID: 10757976
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Differential time-dependent inactivation of P450 3A4 and P450 3A5 by raloxifene: a key role for C239 in quenching reactive intermediates.
    Pearson JT; Wahlstrom JL; Dickmann LJ; Kumar S; Halpert JR; Wienkers LC; Foti RS; Rock DA
    Chem Res Toxicol; 2007 Dec; 20(12):1778-86. PubMed ID: 18001057
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Identification of 17-alpha-ethynylestradiol-modified active site peptides and glutathione conjugates formed during metabolism and inactivation of P450s 2B1 and 2B6.
    Kent UM; Lin HL; Mills DE; Regal KA; Hollenberg PF
    Chem Res Toxicol; 2006 Feb; 19(2):279-87. PubMed ID: 16485904
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Detection of covalent adducts to cytochrome P450 3A4 using liquid chromatography mass spectrometry.
    Bateman KP; Baker J; Wilke M; Lee J; Leriche T; Seto C; Day S; Chauret N; Ouellet M; Nicoll-Griffith DA
    Chem Res Toxicol; 2004 Oct; 17(10):1356-61. PubMed ID: 15487896
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Fluorescent photoaffinity labeling of cytochrome P450 3A4 by lapachenole: identification of modification sites by mass spectrometry.
    Wen B; Doneanu CE; Gartner CA; Roberts AG; Atkins WM; Nelson SD
    Biochemistry; 2005 Feb; 44(6):1833-45. PubMed ID: 15697209
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Elucidation of distinct ligand binding sites for cytochrome P450 3A4.
    Hosea NA; Miller GP; Guengerich FP
    Biochemistry; 2000 May; 39(20):5929-39. PubMed ID: 10821664
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Mechanism-based inactivation of cytochrome P-450-3A4 by mifepristone (RU486).
    He K; Woolf TF; Hollenberg PF
    J Pharmacol Exp Ther; 1999 Feb; 288(2):791-7. PubMed ID: 9918590
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Identification of the heme-modified peptides from cumene hydroperoxide-inactivated cytochrome P450 3A4.
    He K; Bornheim LM; Falick AM; Maltby D; Yin H; Correia MA
    Biochemistry; 1998 Dec; 37(50):17448-57. PubMed ID: 9860860
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Photochromic agents as tools for protein structure study: lapachenole is a photoaffinity ligand of cytochrome P450 3A4.
    Gartner CA; Wen B; Wan J; Becker RS; Jones G; Gygi SP; Nelson SD
    Biochemistry; 2005 Feb; 44(6):1846-55. PubMed ID: 15697210
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The grapefruit juice effect is not limited to cytochrome P450 (P450) 3A4: evidence for bergamottin-dependent inactivation, heme destruction, and covalent binding to protein in P450s 2B6 and 3A5.
    Lin HL; Kent UM; Hollenberg PF
    J Pharmacol Exp Ther; 2005 Apr; 313(1):154-64. PubMed ID: 15608076
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Bioactivation of the cannabinoid receptor antagonist rimonabant to a cytotoxic iminium ion metabolite.
    Foster AJ; Prime LH; Gustafsson F; Temesi DG; Isin EM; Midlöv J; Castagnoli N; Kenna JG
    Chem Res Toxicol; 2013 Jan; 26(1):124-35. PubMed ID: 23234359
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Improved cytochrome P450 3A4 molecular models accurately predict the Phe215 requirement for raloxifene dehydrogenation selectivity.
    Moore CD; Shahrokh K; Sontum SF; Cheatham TE; Yost GS
    Biochemistry; 2010 Oct; 49(41):9011-9. PubMed ID: 20812728
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The inactivation of cytochrome P450 3A5 by 17alpha-ethynylestradiol is cytochrome b5-dependent: metabolic activation of the ethynyl moiety leads to the formation of glutathione conjugates, a heme adduct, and covalent binding to the apoprotein.
    Lin HL; Hollenberg PF
    J Pharmacol Exp Ther; 2007 Apr; 321(1):276-87. PubMed ID: 17251390
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Mechanism-Based Inactivation of Cytochrome P450 3A4 by Benzbromarone.
    Tang LWT; Verma RK; Fan H; Chan ECY
    Mol Pharmacol; 2021 Apr; 99(4):266-276. PubMed ID: 33436520
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Metabolic intermediate complex formation of human cytochrome P450 3A4 by lapatinib.
    Takakusa H; Wahlin MD; Zhao C; Hanson KL; New LS; Chan EC; Nelson SD
    Drug Metab Dispos; 2011 Jun; 39(6):1022-30. PubMed ID: 21363997
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Inactivation of cytochrome P450 (P450) 3A4 but not P450 3A5 by OSI-930, a thiophene-containing anticancer drug.
    Lin HL; Zhang H; Medower C; Hollenberg PF; Johnson WW
    Drug Metab Dispos; 2011 Feb; 39(2):345-50. PubMed ID: 21068193
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.