BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

207 related articles for article (PubMed ID: 17888551)

  • 1. An impact analysis of the application of the threshold of toxicological concern concept to pharmaceuticals.
    Delaney EJ
    Regul Toxicol Pharmacol; 2007 Nov; 49(2):107-24. PubMed ID: 17888551
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Overview of genotoxic impurities in pharmaceutical development.
    Bercu JP; Dobo KL; Gocke E; McGovern TJ
    Int J Toxicol; 2009; 28(6):468-78. PubMed ID: 19966139
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Improved in silico prediction of carcinogenic potency (TD50) and the risk specific dose (RSD) adjusted Threshold of Toxicological Concern (TTC) for genotoxic chemicals and pharmaceutical impurities.
    Contrera JF
    Regul Toxicol Pharmacol; 2011 Feb; 59(1):133-41. PubMed ID: 20933038
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A rationale for determining, testing, and controlling specific impurities in pharmaceuticals that possess potential for genotoxicity.
    Müller L; Mauthe RJ; Riley CM; Andino MM; Antonis DD; Beels C; DeGeorge J; De Knaep AG; Ellison D; Fagerland JA; Frank R; Fritschel B; Galloway S; Harpur E; Humfrey CD; Jacks AS; Jagota N; Mackinnon J; Mohan G; Ness DK; O'Donovan MR; Smith MD; Vudathala G; Yotti L
    Regul Toxicol Pharmacol; 2006 Apr; 44(3):198-211. PubMed ID: 16412543
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Mutagenic impurities in pharmaceuticals: a critique of the derivation of the cancer TTC (Threshold of Toxicological Concern) and recommendations for structural-class-based limits.
    Snodin DJ; McCrossen SD
    Regul Toxicol Pharmacol; 2013 Nov; 67(2):299-316. PubMed ID: 23988886
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Quantitative assessment of cumulative carcinogenic risk for multiple genotoxic impurities in a new drug substance.
    Bercu JP; Hoffman WP; Lee C; Ness DK
    Regul Toxicol Pharmacol; 2008 Aug; 51(3):270-7. PubMed ID: 18550240
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Potentially mutagenic impurities: analysis of structural classes and carcinogenic potencies of chemical intermediates in pharmaceutical syntheses supports alternative methods to the default TTC for calculating safe levels of impurities.
    Galloway SM; Vijayaraj Reddy M; McGettigan K; Gealy R; Bercu J
    Regul Toxicol Pharmacol; 2013 Aug; 66(3):326-35. PubMed ID: 23688841
    [TBL] [Abstract][Full Text] [Related]  

  • 8. In silico approaches to predicting cancer potency for risk assessment of genotoxic impurities in drug substances.
    Bercu JP; Morton SM; Deahl JT; Gombar VK; Callis CM; van Lier RB
    Regul Toxicol Pharmacol; 2010; 57(2-3):300-6. PubMed ID: 20363275
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The Threshold of Toxicological Concern (TTC) in risk assessment.
    Munro IC; Renwick AG; Danielewska-Nikiel B
    Toxicol Lett; 2008 Aug; 180(2):151-6. PubMed ID: 18573621
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Recent developments in the risk assessment of potentially genotoxic impurities in pharmaceutical drug substances.
    Humfrey CD
    Toxicol Sci; 2007 Nov; 100(1):24-8. PubMed ID: 17656486
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Refining the threshold of toxicological concern (TTC) for risk prioritization of trace chemicals in food.
    Felter S; Lane RW; Latulippe ME; Llewellyn GC; Olin SS; Scimeca JA; Trautman TD
    Food Chem Toxicol; 2009 Sep; 47(9):2236-45. PubMed ID: 19531369
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The Dermal Sensitisation Threshold- a TTC approach for allergic contact dermatitis.
    Safford RJ
    Regul Toxicol Pharmacol; 2008 Jul; 51(2):195-200. PubMed ID: 18406502
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structure-based thresholds of toxicological concern--guidance for application to substances present at low levels in the diet.
    Renwick AG
    Toxicol Appl Pharmacol; 2005 Sep; 207(2 Suppl):585-91. PubMed ID: 16019047
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Safety and nutritional assessment of GM plants and derived food and feed: the role of animal feeding trials.
    EFSA GMO Panel Working Group on Animal Feeding Trials
    Food Chem Toxicol; 2008 Mar; 46 Suppl 1():S2-70. PubMed ID: 18328408
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Evaluation of inhalation TTC values with the database RepDose.
    Escher SE; Tluczkiewicz I; Batke M; Bitsch A; Melber C; Kroese ED; Buist HE; Mangelsdorf I
    Regul Toxicol Pharmacol; 2010 Nov; 58(2):259-74. PubMed ID: 20600457
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Application of the threshold of toxicological concern (TTC) to the safety evaluation of cosmetic ingredients.
    Kroes R; Renwick AG; Feron V; Galli CL; Gibney M; Greim H; Guy RH; Lhuguenot JC; van de Sandt JJ
    Food Chem Toxicol; 2007 Dec; 45(12):2533-62. PubMed ID: 17664037
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The threshold of toxicological concern concept in risk assessment.
    Kroes R; Kleiner J; Renwick A
    Toxicol Sci; 2005 Aug; 86(2):226-30. PubMed ID: 15829616
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Assessment of the genotoxic and carcinogenic risks of p-nitrophenol when it is present as an impurity in a drug product.
    Eichenbaum G; Johnson M; Kirkland D; O'Neill P; Stellar S; Bielawne J; DeWire R; Areia D; Bryant S; Weiner S; Desai-Krieger D; Guzzie-Peck P; Evans DC; Tonelli A
    Regul Toxicol Pharmacol; 2009 Oct; 55(1):33-42. PubMed ID: 19500632
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Application of the threshold of toxicological concern concept to pharmaceutical manufacturing operations.
    Dolan DG; Naumann BD; Sargent EV; Maier A; Dourson M
    Regul Toxicol Pharmacol; 2005 Oct; 43(1):1-9. PubMed ID: 16099564
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Correlation of chemical structure with reproductive and developmental toxicity as it relates to the use of the threshold of toxicological concern.
    Laufersweiler MC; Gadagbui B; Baskerville-Abraham IM; Maier A; Willis A; Scialli AR; Carr GJ; Felter SP; Blackburn K; Daston G
    Regul Toxicol Pharmacol; 2012 Feb; 62(1):160-82. PubMed ID: 22019814
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.