149 related articles for article (PubMed ID: 17889532)
1. Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: peptidomimetic replacement of the P(2) amino acid by 2-aminoaryl acids and other non-natural amino acids.
Wang Y; Jia S; Tseng B; Drewe J; Cai SX
Bioorg Med Chem Lett; 2007 Nov; 17(22):6178-82. PubMed ID: 17889532
[TBL] [Abstract][Full Text] [Related]
2. Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: peptidomimetic replacement of the P2 alpha-amino acid by a alpha-hydroxy acid.
Wang Y; Guan L; Jia S; Tseng B; Drewe J; Cai SX
Bioorg Med Chem Lett; 2005 Mar; 15(5):1379-83. PubMed ID: 15713391
[TBL] [Abstract][Full Text] [Related]
3. Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: SAR of the N-protecting group.
Cai SX; Guan L; Jia S; Wang Y; Yang W; Tseng B; Drewe J
Bioorg Med Chem Lett; 2004 Nov; 14(21):5295-300. PubMed ID: 15454214
[TBL] [Abstract][Full Text] [Related]
4. Dipeptidyl aspartyl fluoromethylketones as potent caspase-3 inhibitors: SAR of the P2 amino acid.
Wang Y; Huang JC; Zhou ZL; Yang W; Guastella J; Drewe J; Cai SX
Bioorg Med Chem Lett; 2004 Mar; 14(5):1269-72. PubMed ID: 14980679
[TBL] [Abstract][Full Text] [Related]
5. Lipophilic versus hydrogen-bonding effect in P3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors.
Mellon C; Aspiotis R; Black CW; Bayly CI; Grimm EL; Giroux A; Han Y; Isabel E; McKay DJ; Nicholson DW; Rasper DM; Roy S; Tam J; Thornberry NA; Vaillancourt JP; Xanthoudakis S; Zamboni R
Bioorg Med Chem Lett; 2005 Sep; 15(17):3886-90. PubMed ID: 16023344
[TBL] [Abstract][Full Text] [Related]
6. Design, synthesis, biological evaluation, and structure-activity relationship (SAR) discussion of dipeptidyl boronate proteasome inhibitors, part I: comprehensive understanding of the SAR of alpha-amino acid boronates.
Zhu Y; Zhao X; Zhu X; Wu G; Li Y; Ma Y; Yuan Y; Yang J; Hu Y; Ai L; Gao Q
J Med Chem; 2009 Jul; 52(14):4192-9. PubMed ID: 19537716
[TBL] [Abstract][Full Text] [Related]
7. Structure-activity relationships within a series of caspase inhibitors. Part 2: Heterocyclic warheads.
Ullman BR; Aja T; Chen N; Diaz JL; Gu X; Herrmann J; Kalish VJ; Karanewsky DS; Kodandapani L; Krebs JJ; Linton SD; Meduna SP; Nalley K; Robinson ED; Roggo SP; Sayers RO; Schmitz A; Ternansky RJ; Tomaselli KJ; Wu JC
Bioorg Med Chem Lett; 2005 Aug; 15(15):3632-6. PubMed ID: 15964758
[TBL] [Abstract][Full Text] [Related]
8. Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke.
Linton SD; Aja T; Allegrini PR; Deckwerth TL; Diaz JL; Hengerer B; Herrmann J; Jahangiri KG; Kallen J; Karanewsky DS; Meduna SP; Nalley K; Robinson ED; Roggo S; Rovelli G; Sauter A; Sayers RO; Schmitz A; Smidt R; Ternansky RJ; Tomaselli KJ; Ullman BR; Wiessner C; Wu JC
Bioorg Med Chem Lett; 2004 May; 14(10):2685-91. PubMed ID: 15109679
[TBL] [Abstract][Full Text] [Related]
9. Synthesis and evaluation of novel dipeptidyl benzoyloxymethyl ketones as caspase inhibitors.
Nedev HN; Klaiman G; LeBlanc A; Saragovi HU
Biochem Biophys Res Commun; 2005 Oct; 336(2):397-400. PubMed ID: 16137654
[TBL] [Abstract][Full Text] [Related]
10. Discovery of novel conformationally restricted diazocan peptidomimetics as inhibitors of interleukin-1beta synthesis.
Oppong KA; Ellis CD; Laufersweiler MC; O'Neil SV; Wang Y; Soper DL; Baize MW; Wos JA; De B; Bosch GK; Fancher AN; Lu W; Suchanek MK; Wang RL; Demuth TP
Bioorg Med Chem Lett; 2005 Oct; 15(19):4291-4. PubMed ID: 16046125
[TBL] [Abstract][Full Text] [Related]
11. Human caspase-3 inhibition by Z-tLeu-Asp-H: tLeu(P2) counterbalances Asp(P4) and Glu(P3) specific inhibitor truncation.
Colantonio P; Leboffe L; Bolli A; Marino M; Ascenzi P; Luisi G
Biochem Biophys Res Commun; 2008 Dec; 377(3):757-62. PubMed ID: 18854175
[TBL] [Abstract][Full Text] [Related]
12. Synthesis and evaluation of tricyclic pyrrolopyrimidinones as dipeptide mimetics: inhibition of interleukin-1beta-converting enzyme.
Laufersweiler MC; Wang Y; Soper DL; Suchanek MK; Fancher AN; Lu W; Wang RL; Oppong KA; Ellis CD; Baize MW; O'Neil SV; Wos JA; Demuth TP
Bioorg Med Chem Lett; 2005 Oct; 15(19):4322-6. PubMed ID: 16046129
[TBL] [Abstract][Full Text] [Related]
13. Blocking granule-mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity.
Sedelies KA; Ciccone A; Clarke CJ; Oliaro J; Sutton VR; Scott FL; Silke J; Susanto O; Green DR; Johnstone RW; Bird PI; Trapani JA; Waterhouse NJ
Cell Death Differ; 2008 Apr; 15(4):708-17. PubMed ID: 18202705
[TBL] [Abstract][Full Text] [Related]
14. Reducing the peptidyl features of caspase-3 inhibitors: a structural analysis.
Becker JW; Rotonda J; Soisson SM; Aspiotis R; Bayly C; Francoeur S; Gallant M; Garcia-Calvo M; Giroux A; Grimm E; Han Y; McKay D; Nicholson DW; Peterson E; Renaud J; Roy S; Thornberry N; Zamboni R
J Med Chem; 2004 May; 47(10):2466-74. PubMed ID: 15115390
[TBL] [Abstract][Full Text] [Related]
15. Dipeptide nitrile inhibitors of cathepsin K.
Altmann E; Aichholz R; Betschart C; Buhl T; Green J; Lattmann R; Missbach M
Bioorg Med Chem Lett; 2006 May; 16(9):2549-54. PubMed ID: 16480867
[TBL] [Abstract][Full Text] [Related]
16. Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors.
Han Y; Giroux A; Grimm EL; Aspiotis R; Francoeur S; Bayly CI; Mckay DJ; Roy S; Xanthoudakis S; Vaillancourt JP; Rasper DM; Tam J; Tawa P; Thornberry NA; Paterson EP; Garcia-Calvo M; Becker JW; Rotonda J; Nicholson DW; Zamboni RJ
Bioorg Med Chem Lett; 2004 Feb; 14(3):805-8. PubMed ID: 14741294
[TBL] [Abstract][Full Text] [Related]
17. Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors.
Simpkins LM; Bolton S; Pi Z; Sutton JC; Kwon C; Zhao G; Magnin DR; Augeri DJ; Gungor T; Rotella DP; Sun Z; Liu Y; Slusarchyk WS; Marcinkeviciene J; Robertson JG; Wang A; Robl JA; Atwal KS; Zahler RL; Parker RA; Kirby MS; Hamann LG
Bioorg Med Chem Lett; 2007 Dec; 17(23):6476-80. PubMed ID: 17937986
[TBL] [Abstract][Full Text] [Related]
18. Synthesis and evaluation of vinyl sulfones as caspase-3 inhibitors. A structure-activity study.
Newton AS; Glória PM; Gonçalves LM; dos Santos DJ; Moreira R; Guedes RC; Santos MM
Eur J Med Chem; 2010 Sep; 45(9):3858-63. PubMed ID: 20541849
[TBL] [Abstract][Full Text] [Related]
19. N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: synthesis, in vitro activity, and molecular modeling studies.
Chu W; Zhang J; Zeng C; Rothfuss J; Tu Z; Chu Y; Reichert DE; Welch MJ; Mach RH
J Med Chem; 2005 Dec; 48(24):7637-47. PubMed ID: 16302804
[TBL] [Abstract][Full Text] [Related]
20. Heterocyclic organobismuth(III) induces apoptosis of human promyelocytic leukemic cells through activation of caspases and mitochondrial perturbation.
Iuchi K; Hatano Y; Yagura T
Biochem Pharmacol; 2008 Oct; 76(8):974-86. PubMed ID: 18760261
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
