BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

134 related articles for article (PubMed ID: 17890085)

  • 1. Discovery of 2,4,6-trisubstituted N-arylsulfonyl piperidines as gamma-secretase inhibitors.
    Li H; Asberom T; Bara TA; Clader JW; Greenlee WJ; Josien HB; McBriar MD; Nomeir A; Pissarnitski DA; Rajagopalan M; Xu R; Zhao Z; Song L; Zhang L
    Bioorg Med Chem Lett; 2007 Nov; 17(22):6290-4. PubMed ID: 17890085
    [TBL] [Abstract][Full Text] [Related]  

  • 2. 2,6-Disubstituted N-arylsulfonyl piperidines as gamma-secretase inhibitors.
    Pissarnitski DA; Asberom T; Bara TA; Buevich AV; Clader JW; Greenlee WJ; Guzik HS; Josien HB; Li W; McEwan M; McKittrick BA; Nechuta TL; Parker EM; Sinning L; Smith EM; Song L; Vaccaro HA; Voigt JH; Zhang L; Zhang Q; Zhao Z
    Bioorg Med Chem Lett; 2007 Jan; 17(1):57-62. PubMed ID: 17055268
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Design, synthesis, and structure-activity relationship studies of N-arylsulfonyl morpholines as γ-secretase inhibitors.
    Li H; Xu R; Cole D; Clader JW; Greenlee WJ; Nomeir AA; Song L; Zhang L
    Bioorg Med Chem Lett; 2010 Nov; 20(22):6606-9. PubMed ID: 20933414
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery and X-ray crystallographic analysis of a spiropiperidine iminohydantoin inhibitor of beta-secretase.
    Barrow JC; Stauffer SR; Rittle KE; Ngo PL; Yang Z; Selnick HG; Graham SL; Munshi S; McGaughey GB; Holloway MK; Simon AJ; Price EA; Sankaranarayanan S; Colussi D; Tugusheva K; Lai MT; Espeseth AS; Xu M; Huang Q; Wolfe A; Pietrak B; Zuck P; Levorse DA; Hazuda D; Vacca JP
    J Med Chem; 2008 Oct; 51(20):6259-62. PubMed ID: 18811140
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Small conformationally restricted piperidine N-arylsulfonamides as orally active gamma-secretase inhibitors.
    Josien H; Bara T; Rajagopalan M; Asberom T; Clader JW; Favreau L; Greenlee WJ; Hyde LA; Nomeir AA; Parker EM; Pissarnitski DA; Song L; Wong GT; Zhang L; Zhang Q; Zhao Z
    Bioorg Med Chem Lett; 2007 Oct; 17(19):5330-5. PubMed ID: 17761417
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Novel orally active morpholine N-arylsulfonamides gamma-secretase inhibitors with low CYP 3A4 liability.
    Josien H; Bara T; Rajagopalan M; Clader JW; Greenlee WJ; Favreau L; Hyde LA; Nomeir AA; Parker EM; Song L; Zhang L; Zhang Q
    Bioorg Med Chem Lett; 2009 Nov; 19(21):6032-7. PubMed ID: 19800786
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Substituted 4-morpholine N-arylsulfonamides as γ-secretase inhibitors.
    Zhao Z; Pissarnitski DA; Josien HB; Bara TA; Clader JW; Li H; McBriar MD; Rajagopalan M; Xu R; Terracina G; Hyde L; Song L; Zhang L; Parker EM; Osterman R; Buevich AV
    Eur J Med Chem; 2016 Nov; 124():36-48. PubMed ID: 27560281
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design, synthesis, and evaluation of tetrahydroquinoline and pyrrolidine sulfonamide carbamates as gamma-secretase inhibitors.
    Guo T; Gu H; Hobbs DW; Rokosz LL; Stauffer TM; Jacob B; Clader JW
    Bioorg Med Chem Lett; 2007 Jun; 17(11):3010-3. PubMed ID: 17418571
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious gamma-secretase inhibitors.
    Ye XM; Konradi AW; Smith J; Xu YZ; Dressen D; Garofalo AW; Marugg J; Sham HL; Truong AP; Jagodzinski J; Pleiss M; Zhang H; Goldbach E; Sauer JM; Brigham E; Bova M; Basi GS
    Bioorg Med Chem Lett; 2010 Apr; 20(7):2195-9. PubMed ID: 20207136
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious gamma-secretase inhibitors (Part II).
    Ye XM; Konradi AW; Smith J; Aubele DL; Garofalo AW; Marugg J; Neitzel ML; Semko CM; Sham HL; Sun M; Truong AP; Wu J; Zhang H; Goldbach E; Sauer JM; Brigham EF; Bova M; Basi GS
    Bioorg Med Chem Lett; 2010 Jun; 20(12):3502-6. PubMed ID: 20529683
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Discovery of amide and heteroaryl isosteres as carbamate replacements in a series of orally active gamma-secretase inhibitors.
    McBriar MD; Clader JW; Chu I; Del Vecchio RA; Favreau L; Greenlee WJ; Hyde LA; Nomeir AA; Parker EM; Pissarnitski DA; Song L; Zhang L; Zhao Z
    Bioorg Med Chem Lett; 2008 Jan; 18(1):215-9. PubMed ID: 17988864
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Design, synthesis and structure-activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors.
    Aubele DL; Truong AP; Dressen DB; Probst GD; Bowers S; Mattson MN; Semko CM; Sun M; Garofalo AW; Konradi AW; Sham HL; Zmolek W; Wong K; Goldbach E; Quinn KP; Sauer JM; Brigham EF; Wallace W; Nguyen L; Bova MP; Hemphill SS; Basi G
    Bioorg Med Chem Lett; 2011 Oct; 21(19):5791-4. PubMed ID: 21885276
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Lead optimization of 4,4-biaryl piperidine amides as γ-secretase inhibitors.
    Close J; Heidebrecht R; Hendrix J; Li C; Munoz B; Surdi L; Kattar S; Tempest P; Moses P; Geng X; Hughes B; Smotrov N; Moxham C; Chapnick J; Kariv I; Nikov G; Burke JE; Deshmukh S; Jeliazkova-Mecheva V; Leach JK; Diaz D; Xu L; Yang Z; Kwei G; Moy L; Shah S; Tanga F; Kenefic C; Savage D; Shearman M; Ball RG; McNevin MJ; Markarewicz A; Miller T
    Bioorg Med Chem Lett; 2012 May; 22(9):3203-7. PubMed ID: 22483609
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Design and synthesis of an aminopiperidine series of γ-secretase modulators.
    Kobayashi T; Iwama S; Fusano A; Kato Y; Ikeda A; Teranishi Y; Nishihara A; Tobe M
    Bioorg Med Chem Lett; 2014 Jan; 24(1):378-81. PubMed ID: 24269163
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease.
    Mayer SC; Kreft AF; Harrison B; Abou-Gharbia M; Antane M; Aschmies S; Atchison K; Chlenov M; Cole DC; Comery T; Diamantidis G; Ellingboe J; Fan K; Galante R; Gonzales C; Ho DM; Hoke ME; Hu Y; Huryn D; Jain U; Jin M; Kremer K; Kubrak D; Lin M; Lu P; Magolda R; Martone R; Moore W; Oganesian A; Pangalos MN; Porte A; Reinhart P; Resnick L; Riddell DR; Sonnenberg-Reines J; Stock JR; Sun SC; Wagner E; Wang T; Woller K; Xu Z; Zaleska MM; Zeldis J; Zhang M; Zhou H; Jacobsen JS
    J Med Chem; 2008 Dec; 51(23):7348-51. PubMed ID: 19012391
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structural optimization of a CXCR2-directed antagonist that indirectly inhibits gamma-secretase and reduces Abeta.
    Bakshi P; Jin C; Broutin P; Berhane B; Reed J; Mullan M
    Bioorg Med Chem; 2009 Dec; 17(23):8102-12. PubMed ID: 19853461
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Diamide amino-imidazoles: a novel series of γ-secretase inhibitors for the treatment of Alzheimer's disease.
    Brodney MA; Auperin DD; Becker SL; Bronk BS; Brown TM; Coffman KJ; Finley JE; Hicks CD; Karmilowicz MJ; Lanz TA; Liston D; Liu X; Martin BA; Nelson RB; Nolan CE; Oborski CE; Parker CP; Richter KE; Pozdnyakov N; Sahagan BG; Schachter JB; Sokolowski SA; Tate B; Van Deusen JW; Wood DE; Wood KM
    Bioorg Med Chem Lett; 2011 May; 21(9):2631-6. PubMed ID: 21269825
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Amino-caprolactam γ-secretase inhibitors showing potential for the treatment of Alzheimer's disease.
    Neitzel ML; Aubele DL; Marugg JL; Jagodzinski JJ; Konradi AW; Pleiss MA; Szoke B; Zmolek W; Goldbach E; Quinn KP; Sauer JM; Brigham EF; Wallace W; Bova MP; Hemphill S; Basi G
    Bioorg Med Chem Lett; 2011 Jun; 21(12):3715-20. PubMed ID: 21571529
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Discovery of 4-aminomethylphenylacetic acids as γ-secretase modulators via a scaffold design approach.
    Xin Z; Peng H; Zhang A; Talreja T; Kumaravel G; Xu L; Rohde E; Jung MY; Shackett MN; Kocisko D; Chollate S; Dunah AW; Snodgrass-Belt PA; Arnold HM; Taveras AG; Rhodes KJ; Scannevin RH
    Bioorg Med Chem Lett; 2011 Dec; 21(24):7277-80. PubMed ID: 22061640
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Piperidine-based renin inhibitors: upper chain optimization.
    Corminboeuf O; Bezençon O; Remeň L; Grisostomi C; Richard-Bildstein S; Bur D; Prade L; Strickner P; Hess P; Fischli W; Steiner B; Treiber A
    Bioorg Med Chem Lett; 2010 Nov; 20(21):6291-6. PubMed ID: 20843690
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.