BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

388 related articles for article (PubMed ID: 17900172)

  • 1. Transport, metabolism, and hepatotoxicity of flutamide, drug-drug interaction with acetaminophen involving phase I and phase II metabolites.
    Kostrubsky SE; Strom SC; Ellis E; Nelson SD; Mutlib AE
    Chem Res Toxicol; 2007 Oct; 20(10):1503-12. PubMed ID: 17900172
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Flutamide metabolism in four different species in vitro and identification of flutamide metabolites in human patient urine by high performance liquid chromatography/tandem mass spectrometry.
    Tevell A; Lennernäs H; Jönsson M; Norlin M; Lennernäs B; Bondesson U; Hedeland M
    Drug Metab Dispos; 2006 Jun; 34(6):984-92. PubMed ID: 16540588
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Protective effect of diallyl sulfone against acetaminophen-induced hepatotoxicity in mice.
    Lin MC; Wang EJ; Patten C; Lee MJ; Xiao F; Reuhl KR; Yang CS
    J Biochem Toxicol; 1996; 11(1):11-20. PubMed ID: 8806047
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Inhibition of hepatobiliary transport as a predictive method for clinical hepatotoxicity of nefazodone.
    Kostrubsky SE; Strom SC; Kalgutkar AS; Kulkarni S; Atherton J; Mireles R; Feng B; Kubik R; Hanson J; Urda E; Mutlib AE
    Toxicol Sci; 2006 Apr; 90(2):451-9. PubMed ID: 16410371
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Interspecies differences in acetaminophen sensitivity of human, rat, and mouse primary hepatocytes.
    Jemnitz K; Veres Z; Monostory K; Kóbori L; Vereczkey L
    Toxicol In Vitro; 2008 Jun; 22(4):961-7. PubMed ID: 18346862
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Phenobarbital and phenytoin increased acetaminophen hepatotoxicity due to inhibition of UDP-glucuronosyltransferases in cultured human hepatocytes.
    Kostrubsky SE; Sinclair JF; Strom SC; Wood S; Urda E; Stolz DB; Wen YH; Kulkarni S; Mutlib A
    Toxicol Sci; 2005 Sep; 87(1):146-55. PubMed ID: 15933229
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Bioactivation of flutamide metabolites by human liver microsomes.
    Kang P; Dalvie D; Smith E; Zhou S; Deese A; Nieman JA
    Drug Metab Dispos; 2008 Jul; 36(7):1425-37. PubMed ID: 18411402
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The role of conjugation in hepatotoxicity of troglitazone in human and porcine hepatocyte cultures.
    Kostrubsky VE; Sinclair JF; Ramachandran V; Venkataramanan R; Wen YH; Kindt E; Galchev V; Rose K; Sinz M; Strom SC
    Drug Metab Dispos; 2000 Oct; 28(10):1192-7. PubMed ID: 10997939
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Role of enzymatic N-hydroxylation and reduction in flutamide metabolite-induced liver toxicity.
    Ohbuchi M; Miyata M; Nagai D; Shimada M; Yoshinari K; Yamazoe Y
    Drug Metab Dispos; 2009 Jan; 37(1):97-105. PubMed ID: 18832480
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Detection of a new N-oxidized metabolite of flutamide, N-[4-nitro-3-(trifluoromethyl)phenyl]hydroxylamine, in human liver microsomes and urine of prostate cancer patients.
    Goda R; Nagai D; Akiyama Y; Nishikawa K; Ikemoto I; Aizawa Y; Nagata K; Yamazoe Y
    Drug Metab Dispos; 2006 May; 34(5):828-35. PubMed ID: 16507648
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Metabolism of the antiandrogenic drug (Flutamide) by human CYP1A2.
    Shet MS; McPhaul M; Fisher CW; Stallings NR; Estabrook RW
    Drug Metab Dispos; 1997 Nov; 25(11):1298-303. PubMed ID: 9351907
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Kinetics of acetaminophen glucuronidation by UDP-glucuronosyltransferases 1A1, 1A6, 1A9 and 2B15. Potential implications in acetaminophen-induced hepatotoxicity.
    Mutlib AE; Goosen TC; Bauman JN; Williams JA; Kulkarni S; Kostrubsky S
    Chem Res Toxicol; 2006 May; 19(5):701-9. PubMed ID: 16696573
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Effects of phenethyl isothiocyanate on acetaminophen metabolism and hepatotoxicity in mice.
    Li Y; Wang EJ; Chen L; Stein AP; Reuhl KR; Yang CS
    Toxicol Appl Pharmacol; 1997 Jun; 144(2):306-14. PubMed ID: 9194414
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Protection by clofibrate against acetaminophen hepatotoxicity in male CD-1 mice is associated with an early increase in biliary concentration of acetaminophen-glutathione adducts.
    Manautou JE; Tveit A; Hoivik DJ; Khairallah EA; Cohen SD
    Toxicol Appl Pharmacol; 1996 Sep; 140(1):30-8. PubMed ID: 8806867
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Effect of acetaminophen administration to rats chronically exposed to depleted uranium.
    Guéguen Y; Grandcolas L; Baudelin C; Grison S; Tissandié E; Jourdain JR; Paquet F; Voisin P; Aigueperse J; Gourmelon P; Souidi M
    Toxicology; 2007 Jan; 229(1-2):62-72. PubMed ID: 17126469
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A Cytochrome P450-Independent Mechanism of Acetaminophen-Induced Injury in Cultured Mouse Hepatocytes.
    Miyakawa K; Albee R; Letzig LG; Lehner AF; Scott MA; Buchweitz JP; James LP; Ganey PE; Roth RA
    J Pharmacol Exp Ther; 2015 Aug; 354(2):230-7. PubMed ID: 26065700
    [TBL] [Abstract][Full Text] [Related]  

  • 17. [Sex-difference on flutamide metabolism in rat liver microsomal cytochrome P450 1A2].
    Wang HX; Li D; Xu CJ; Liu X
    Yao Xue Xue Bao; 2002 Aug; 37(8):608-10. PubMed ID: 12567773
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Metabolism and hepatic toxicity of flutamide in cytochrome P450 1A2 knockout SV129 mice.
    Matsuzaki Y; Nagai D; Ichimura E; Goda R; Tomura A; Doi M; Nishikawa K
    J Gastroenterol; 2006 Mar; 41(3):231-9. PubMed ID: 16699857
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Comparison of in vitro bioactivation of flutamide and its cyano analogue: evidence for reductive activation by human NADPH:cytochrome P450 reductase.
    Wen B; Coe KJ; Rademacher P; Fitch WL; Monshouwer M; Nelson SD
    Chem Res Toxicol; 2008 Dec; 21(12):2393-406. PubMed ID: 19548358
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Cytotoxicity of flutamide and 2-hydroxyflutamide and their effects on CYP1A2 mRNA in primary rat hepatocytes.
    Wang HX; Ma XC; Deng QL; Li D
    Acta Pharmacol Sin; 2002 Jun; 23(6):562-6. PubMed ID: 12060533
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 20.