1081 related articles for article (PubMed ID: 17907785)
21. Bioactivation of isothiazoles: minimizing the risk of potential toxicity in drug discovery.
Teffera Y; Choquette D; Liu J; Colletti AE; Hollis LS; Lin MH; Zhao Z
Chem Res Toxicol; 2010 Nov; 23(11):1743-52. PubMed ID: 20825217
[TBL] [Abstract][Full Text] [Related]
22. The major metabolite of equilin, 4-hydroxyequilin, autoxidizes to an o-quinone which isomerizes to the potent cytotoxin 4-hydroxyequilenin-o-quinone.
Zhang F; Chen Y; Pisha E; Shen L; Xiong Y; van Breemen RB; Bolton JL
Chem Res Toxicol; 1999 Feb; 12(2):204-13. PubMed ID: 10027800
[TBL] [Abstract][Full Text] [Related]
23. Characterization of the NADPH-dependent covalent binding of [14C]halothane to human liver microsomes: a role for cytochrome P4502E1 at low substrate concentrations.
Madan A; Parkinson A
Drug Metab Dispos; 1996 Dec; 24(12):1307-13. PubMed ID: 8971135
[TBL] [Abstract][Full Text] [Related]
24. Trimethoprim: novel reactive intermediates and bioactivation pathways by cytochrome p450s.
Damsten MC; de Vlieger JS; Niessen WM; Irth H; Vermeulen NP; Commandeur JN
Chem Res Toxicol; 2008 Nov; 21(11):2181-7. PubMed ID: 18816075
[TBL] [Abstract][Full Text] [Related]
25. Evidence that the catechol 3,4-Dihydroxytamoxifen is a proximate intermediate to the reactive species binding covalently to proteins.
Dehal SS; Kupfer D
Cancer Res; 1996 Mar; 56(6):1283-90. PubMed ID: 8640815
[TBL] [Abstract][Full Text] [Related]
26. A novel bioactivation pathway for 2-[2-(2,6-dichlorophenyl)aminophenyl]ethanoic acid (diclofenac) initiated by cytochrome P450-mediated oxidative decarboxylation.
Grillo MP; Ma J; Teffera Y; Waldon DJ
Drug Metab Dispos; 2008 Sep; 36(9):1740-4. PubMed ID: 18541695
[TBL] [Abstract][Full Text] [Related]
27. Detection of novel reactive metabolites of trazodone: evidence for CYP2D6-mediated bioactivation of m-chlorophenylpiperazine.
Wen B; Ma L; Rodrigues AD; Zhu M
Drug Metab Dispos; 2008 May; 36(5):841-50. PubMed ID: 18238857
[TBL] [Abstract][Full Text] [Related]
28. Bioactivation of coumarin in rat olfactory mucosal microsomes: Detection of protein covalent binding and identification of reactive intermediates through analysis of glutathione adducts.
Zhuo X; Zhao W; Zheng J; Humphreys WG; Shu YZ; Zhu M
Chem Biol Interact; 2009 Oct; 181(2):227-35. PubMed ID: 19576871
[TBL] [Abstract][Full Text] [Related]
29. Inhibition of glutathione S-transferase activity by the quinoid metabolites of equine estrogens.
Chang M; Zhang F; Shen L; Pauss N; Alam I; van Breemen RB; Blond SY; Bolton JL
Chem Res Toxicol; 1998 Jul; 11(7):758-65. PubMed ID: 9671538
[TBL] [Abstract][Full Text] [Related]
30. Metabolic activation of troglitazone: identification of a reactive metabolite and mechanisms involved.
He K; Talaat RE; Pool WF; Reily MD; Reed JE; Bridges AJ; Woolf TF
Drug Metab Dispos; 2004 Jun; 32(6):639-46. PubMed ID: 15155556
[TBL] [Abstract][Full Text] [Related]
31. Bioactivation of a toxic metabolite of valproic acid, (E)-2-propyl-2,4-pentadienoic acid, via glucuronidation. LC/MS/MS characterization of the GSH-glucuronide diconjugates.
Tang W; Abbott FS
Chem Res Toxicol; 1996 Mar; 9(2):517-26. PubMed ID: 8839057
[TBL] [Abstract][Full Text] [Related]
32. Development and evaluation of an electrochemical method for studying reactive phase-I metabolites: correlation to in vitro drug metabolism.
Madsen KG; Olsen J; Skonberg C; Hansen SH; Jurva U
Chem Res Toxicol; 2007 May; 20(5):821-31. PubMed ID: 17447796
[TBL] [Abstract][Full Text] [Related]
33. DT-diaphorase and peroxidase influence the covalent binding of the metabolites of phenol, the major metabolite of benzene.
Smart RC; Zannoni VG
Mol Pharmacol; 1984 Jul; 26(1):105-11. PubMed ID: 6749127
[TBL] [Abstract][Full Text] [Related]
34. Phencyclidine iminium ion. NADPH-dependent metabolism, covalent binding to macromolecules, and inactivation of cytochrome(s) P-450.
Hoag MK; Trevor AJ; Kalir A; Castagnoli N
Drug Metab Dispos; 1987; 15(4):485-90. PubMed ID: 2888621
[TBL] [Abstract][Full Text] [Related]
35. Metabolism and bioactivation of clozapine by human liver in vitro.
Pirmohamed M; Williams D; Madden S; Templeton E; Park BK
J Pharmacol Exp Ther; 1995 Mar; 272(3):984-90. PubMed ID: 7891353
[TBL] [Abstract][Full Text] [Related]
36. Effect of hyperthyroidism on the in vitro metabolism and covalent binding of 1,1-dichloroethylene in rat liver microsomes.
Gunasena GH; Kanz MF
J Toxicol Environ Health; 1997 Oct; 52(2):169-88. PubMed ID: 9310148
[TBL] [Abstract][Full Text] [Related]
37. Bioactivation of flutamide metabolites by human liver microsomes.
Kang P; Dalvie D; Smith E; Zhou S; Deese A; Nieman JA
Drug Metab Dispos; 2008 Jul; 36(7):1425-37. PubMed ID: 18411402
[TBL] [Abstract][Full Text] [Related]
38. Metabolic activation of a pyrazinone-containing thrombin inhibitor. Evidence for novel biotransformation involving pyrazinone ring oxidation, rearrangement, and covalent binding to proteins.
Singh R; Silva Elipe MV; Pearson PG; Arison BH; Wong BK; White R; Yu X; Burgey CS; Lin JH; Baillie TA
Chem Res Toxicol; 2003 Feb; 16(2):198-207. PubMed ID: 12588191
[TBL] [Abstract][Full Text] [Related]
39. Bioactivation of 6,7-dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-d]pyrimidine (U-89843) to reactive intermediates that bind covalently to macromolecules and produce genotoxicity.
Zhao Z; Koeplinger KA; Padbury GE; Hauer MJ; Bundy GL; Banitt LS; Schwartz TM; Zimmermann DC; Harbach PR; Mayo JK; Aaron CS
Chem Res Toxicol; 1996 Dec; 9(8):1230-9. PubMed ID: 8951224
[TBL] [Abstract][Full Text] [Related]
40. Glutathione S-transferase conjugation of organophosphorus pesticides yields S-phospho-, S-aryl-, and S-alkylglutathione derivatives.
Fujioka K; Casida JE
Chem Res Toxicol; 2007 Aug; 20(8):1211-7. PubMed ID: 17645302
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
