402 related articles for article (PubMed ID: 17911105)
1. Active gamma-secretase complexes contain only one of each component.
Sato T; Diehl TS; Narayanan S; Funamoto S; Ihara Y; De Strooper B; Steiner H; Haass C; Wolfe MS
J Biol Chem; 2007 Nov; 282(47):33985-93. PubMed ID: 17911105
[TBL] [Abstract][Full Text] [Related]
2. p53-Dependent Aph-1 and Pen-2 anti-apoptotic phenotype requires the integrity of the gamma-secretase complex but is independent of its activity.
Dunys J; Kawarai T; Sevalle J; Dolcini V; George-Hyslop PS; Da Costa CA; Checler F
J Biol Chem; 2007 Apr; 282(14):10516-25. PubMed ID: 17276981
[TBL] [Abstract][Full Text] [Related]
3. S-palmitoylation of gamma-secretase subunits nicastrin and APH-1.
Cheng H; Vetrivel KS; Drisdel RC; Meckler X; Gong P; Leem JY; Li T; Carter M; Chen Y; Nguyen P; Iwatsubo T; Tomita T; Wong PC; Green WN; Kounnas MZ; Thinakaran G
J Biol Chem; 2009 Jan; 284(3):1373-84. PubMed ID: 19028695
[TBL] [Abstract][Full Text] [Related]
4. Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates.
Chen AC; Guo LY; Ostaszewski BL; Selkoe DJ; LaVoie MJ
J Biol Chem; 2010 Apr; 285(15):11378-91. PubMed ID: 20145246
[TBL] [Abstract][Full Text] [Related]
5. Toward the structure of presenilin/γ-secretase and presenilin homologs.
Wolfe MS
Biochim Biophys Acta; 2013 Dec; 1828(12):2886-97. PubMed ID: 24099007
[TBL] [Abstract][Full Text] [Related]
6. Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch.
Lee SF; Shah S; Li H; Yu C; Han W; Yu G
J Biol Chem; 2002 Nov; 277(47):45013-9. PubMed ID: 12297508
[TBL] [Abstract][Full Text] [Related]
7. Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin.
LaVoie MJ; Fraering PC; Ostaszewski BL; Ye W; Kimberly WT; Wolfe MS; Selkoe DJ
J Biol Chem; 2003 Sep; 278(39):37213-22. PubMed ID: 12857757
[TBL] [Abstract][Full Text] [Related]
8. Gamma-secretase--intramembrane protease with a complex.
Wolfe MS
Sci Aging Knowledge Environ; 2003 Mar; 2003(11):PE7. PubMed ID: 12844518
[TBL] [Abstract][Full Text] [Related]
9. Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.
Shirotani K; Edbauer D; Kostka M; Steiner H; Haass C
J Neurochem; 2004 Jun; 89(6):1520-7. PubMed ID: 15189355
[TBL] [Abstract][Full Text] [Related]
10. Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals.
Li T; Ma G; Cai H; Price DL; Wong PC
J Neurosci; 2003 Apr; 23(8):3272-7. PubMed ID: 12716934
[TBL] [Abstract][Full Text] [Related]
11. Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2.
Kimberly WT; LaVoie MJ; Ostaszewski BL; Ye W; Wolfe MS; Selkoe DJ
Proc Natl Acad Sci U S A; 2003 May; 100(11):6382-7. PubMed ID: 12740439
[TBL] [Abstract][Full Text] [Related]
12. Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex.
Fraering PC; LaVoie MJ; Ye W; Ostaszewski BL; Kimberly WT; Selkoe DJ; Wolfe MS
Biochemistry; 2004 Jan; 43(2):323-33. PubMed ID: 14717586
[TBL] [Abstract][Full Text] [Related]
13. Nicastrin is dispensable for gamma-secretase protease activity in the presence of specific presenilin mutations.
Futai E; Yagishita S; Ishiura S
J Biol Chem; 2009 May; 284(19):13013-22. PubMed ID: 19254953
[TBL] [Abstract][Full Text] [Related]
14. Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex.
De Strooper B
Neuron; 2003 Apr; 38(1):9-12. PubMed ID: 12691659
[TBL] [Abstract][Full Text] [Related]
15. Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage.
Chyung JH; Raper DM; Selkoe DJ
J Biol Chem; 2005 Feb; 280(6):4383-92. PubMed ID: 15569674
[TBL] [Abstract][Full Text] [Related]
16. Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria.
Hansson CA; Frykman S; Farmery MR; Tjernberg LO; Nilsberth C; Pursglove SE; Ito A; Winblad B; Cowburn RF; Thyberg J; Ankarcrona M
J Biol Chem; 2004 Dec; 279(49):51654-60. PubMed ID: 15456764
[TBL] [Abstract][Full Text] [Related]
17. Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components.
Zhang YW; Luo WJ; Wang H; Lin P; Vetrivel KS; Liao F; Li F; Wong PC; Farquhar MG; Thinakaran G; Xu H
J Biol Chem; 2005 Apr; 280(17):17020-6. PubMed ID: 15711015
[TBL] [Abstract][Full Text] [Related]
18. Evidence That the "Lid" Domain of Nicastrin Is Not Essential for Regulating γ-Secretase Activity.
Zhang X; Sullivan E; Scimeca M; Wu X; Li YM; Sisodia SS
J Biol Chem; 2016 Mar; 291(13):6748-53. PubMed ID: 26887941
[TBL] [Abstract][Full Text] [Related]
19. aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation.
Francis R; McGrath G; Zhang J; Ruddy DA; Sym M; Apfeld J; Nicoll M; Maxwell M; Hai B; Ellis MC; Parks AL; Xu W; Li J; Gurney M; Myers RL; Himes CS; Hiebsch R; Ruble C; Nye JS; Curtis D
Dev Cell; 2002 Jul; 3(1):85-97. PubMed ID: 12110170
[TBL] [Abstract][Full Text] [Related]
20. Purification and characterization of the human gamma-secretase complex.
Fraering PC; Ye W; Strub JM; Dolios G; LaVoie MJ; Ostaszewski BL; van Dorsselaer A; Wang R; Selkoe DJ; Wolfe MS
Biochemistry; 2004 Aug; 43(30):9774-89. PubMed ID: 15274632
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
