114 related articles for article (PubMed ID: 17929793)
1. Discovery of orally efficacious tetracyclic metabotropic glutamate receptor 1 (mGluR1) antagonists for the treatment of chronic pain.
Wu WL; Burnett DA; Domalski M; Greenlee WJ; Li C; Bertorelli R; Fredduzzi S; Lozza G; Veltri A; Reggiani A
J Med Chem; 2007 Nov; 50(23):5550-3. PubMed ID: 17929793
[TBL] [Abstract][Full Text] [Related]
2. Discovery and biological evaluation of tetrahydrothieno[2,3-c]pyridine derivatives as selective metabotropic glutamate receptor 1 antagonists for the potential treatment of neuropathic pain.
Nam M; Kim T; Kwak J; Seo SH; Ko MK; Lim EJ; Min SJ; Cho YS; Keum G; Baek DJ; Lee J; Pae AN
Eur J Med Chem; 2015 Jun; 97():245-58. PubMed ID: 25984841
[TBL] [Abstract][Full Text] [Related]
3. Synthesis and biological evaluation of aryl isoxazole derivatives as metabotropic glutamate receptor 1 antagonists: a potential treatment for neuropathic pain.
Cho GH; Kim T; Son WS; Seo SH; Min SJ; Cho YS; Keum G; Jeong KS; Koh HY; Lee J; Pae AN
Bioorg Med Chem Lett; 2015 Mar; 25(6):1324-8. PubMed ID: 25677662
[TBL] [Abstract][Full Text] [Related]
4. [Research progress of selective mGluR1 antagonists].
Yang YL; Sun W; Peng C; Zhang XY; Yang XH
Yao Xue Xue Bao; 2011 Oct; 46(10):1167-72. PubMed ID: 22242445
[TBL] [Abstract][Full Text] [Related]
5. Pyridazinoquinolinetriones as NMDA glycine-site antagonists with oral antinociceptive activity in a model of neuropathic pain.
Bare TM; Brown DG; Horchler CL; Murphy M; Urbanek RA; Alford V; Barlaam C; Dyroff MC; Empfield JB; Forst JM; Herzog KJ; Keith RA; Kirschner AS; Lee CM; Lewis J; McLaren FM; Neilson KL; Steelman GB; Trivedi S; Vacek EP; Xiao W
J Med Chem; 2007 Jun; 50(13):3113-31. PubMed ID: 17542571
[TBL] [Abstract][Full Text] [Related]
6. Tricyclic thienopyridine-pyrimidones/thienopyrimidine-pyrimidones as orally efficacious mGluR1 antagonists for neuropathic pain.
Sasikumar TK; Qiang L; Burnett DA; Greenlee WJ; Li C; Heimark L; Pramanik B; Grilli M; Bertorelli R; Lozza G; Reggiani A
Bioorg Med Chem Lett; 2009 Jun; 19(12):3199-203. PubMed ID: 19433355
[TBL] [Abstract][Full Text] [Related]
7. From pyrroles to 1-oxo-2,3,4,9-tetrahydro-1H-beta-carbolines: a new class of orally bioavailable mGluR1 antagonists.
Di Fabio R; Micheli F; Alvaro G; Cavanni P; Donati D; Gagliardi T; Fontana G; Giovannini R; Maffeis M; Mingardi A; Tranquillini ME; Vitulli G
Bioorg Med Chem Lett; 2007 Apr; 17(8):2254-9. PubMed ID: 17276684
[TBL] [Abstract][Full Text] [Related]
8. Prospects for metabotropic glutamate 1 receptor antagonists in the treatment of neuropathic pain.
Schkeryantz JM; Kingston AE; Johnson MP
J Med Chem; 2007 May; 50(11):2563-8. PubMed ID: 17489573
[No Abstract] [Full Text] [Related]
9. Structure-activity relationship of triazafluorenone derivatives as potent and selective mGluR1 antagonists.
Zheng GZ; Bhatia P; Daanen J; Kolasa T; Patel M; Latshaw S; El Kouhen OF; Chang R; Uchic ME; Miller L; Nakane M; Lehto SG; Honore MP; Moreland RB; Brioni JD; Stewart AO
J Med Chem; 2005 Nov; 48(23):7374-88. PubMed ID: 16279797
[TBL] [Abstract][Full Text] [Related]
10. Discovery and biological profile of 4-(1-aryltriazol-4-yl)-tetrahydropyridines as an orally active new class of metabotropic glutamate receptor 1 antagonist.
Ito S; Satoh A; Nagatomi Y; Hirata Y; Suzuki G; Kimura T; Satow A; Maehara S; Hikichi H; Hata M; Kawamoto H; Ohta H
Bioorg Med Chem; 2008 Nov; 16(22):9817-29. PubMed ID: 18849168
[TBL] [Abstract][Full Text] [Related]
11. Correlation between brain/plasma ratios and efficacy in neuropathic pain models of selective metabotropic glutamate receptor 1 antagonists.
Zheng GZ; Bhatia P; Kolasa T; Patel M; El Kouhen OF; Chang R; Uchic ME; Miller L; Baker S; Lehto SG; Honore P; Wetter JM; Marsh KC; Moreland RB; Brioni JD; Stewart AO
Bioorg Med Chem Lett; 2006 Sep; 16(18):4936-40. PubMed ID: 16809035
[TBL] [Abstract][Full Text] [Related]
12. Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists.
Nelson DW; Gregg RJ; Kort ME; Perez-Medrano A; Voight EA; Wang Y; Grayson G; Namovic MT; Donnelly-Roberts DL; Niforatos W; Honore P; Jarvis MF; Faltynek CR; Carroll WA
J Med Chem; 2006 Jun; 49(12):3659-66. PubMed ID: 16759108
[TBL] [Abstract][Full Text] [Related]
13. Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A-841720, a novel non-competitive mGluR1 receptor antagonist.
El-Kouhen O; Lehto SG; Pan JB; Chang R; Baker SJ; Zhong C; Hollingsworth PR; Mikusa JP; Cronin EA; Chu KL; McGaraughty SP; Uchic ME; Miller LN; Rodell NM; Patel M; Bhatia P; Mezler M; Kolasa T; Zheng GZ; Fox GB; Stewart AO; Decker MW; Moreland RB; Brioni JD; Honore P
Br J Pharmacol; 2006 Nov; 149(6):761-74. PubMed ID: 17016515
[TBL] [Abstract][Full Text] [Related]
14. Discovery of ITI-333, a Novel Orally Bioavailable Molecule Targeting Multiple Receptors for the Treatment of Pain and Other Disorders.
Li P; Zhang Q; Zheng H; Qiao Y; Snyder GL; Martin T; Yao W; Zhang L; Davis RE
J Med Chem; 2024 Jun; 67(11):9355-9373. PubMed ID: 38805667
[TBL] [Abstract][Full Text] [Related]
15. Metabotropic receptors as targets for drugs of potential use in the treatment of neuropathic pain.
Chiechio S; Copani A; Melchiorri D; Canudas AM; Storto M; Calvani M; Nicolai R; Nicoletti F
J Endocrinol Invest; 2004; 27(6 Suppl):171-6. PubMed ID: 15481819
[TBL] [Abstract][Full Text] [Related]
16. Fused tricyclic mGluR1 antagonists for the treatment of neuropathic pain.
Bennett CE; Burnett DA; Greenlee WJ; Knutson CE; Korakas P; Li C; Tulshian D; Wu WL; Bertorelli R; Fredduzzi S; Grilli M; Lozza G; Reggiani A; Veltri A
Bioorg Med Chem Lett; 2012 Feb; 22(4):1575-8. PubMed ID: 22266036
[TBL] [Abstract][Full Text] [Related]
17. Synthesis and SAR development of novel mGluR1 antagonists for the treatment of chronic pain.
Brumfield S; Korakas P; Silverman LS; Tulshian D; Matasi JJ; Qiang L; Bennett CE; Burnett DA; Greenlee WJ; Knutson CE; Wu WL; Sasikumar TK; Domalski M; Bertorelli R; Grilli M; Lozza G; Reggiani A; Li C
Bioorg Med Chem Lett; 2012 Dec; 22(23):7223-6. PubMed ID: 23084894
[TBL] [Abstract][Full Text] [Related]
18. Synthesis and pharmacological characterisation of 2,4-dicarboxy-pyrroles as selective non-competitive mGluR1 antagonists.
Micheli F; Fabio RD; Cavanni P; Rimland JM; Capelli AM; Chiamulera C; Corsi M; Corti C; Donati D; Feriani A; Ferraguti F; Maffeis M; Missio A; Ratti E; Paio A; Pachera R; Quartaroli M; Reggiani A; Sabbatini FM; Trist DG; Ugolini A; Vitulli G
Bioorg Med Chem; 2003 Jan; 11(2):171-83. PubMed ID: 12470711
[TBL] [Abstract][Full Text] [Related]
19. 3-Phenyl-5-isothiazole carboxamides with potent mGluR1 antagonist activity.
Fisher MJ; Backer RT; Barth VN; Garbison KE; Gruber JM; Heinz BA; Iyengar S; Hollinshead SP; Kingston A; Kuklish SL; Li L; Nisenbaum ES; Peters SC; Phebus L; Simmons RM; van der Aar E
Bioorg Med Chem Lett; 2012 Apr; 22(7):2514-7. PubMed ID: 22386665
[TBL] [Abstract][Full Text] [Related]
20. Tricyclic thiazolopyrazole derivatives as metabotropic glutamate receptor 4 positive allosteric modulators.
Hong SP; Liu KG; Ma G; Sabio M; Uberti MA; Bacolod MD; Peterson J; Zou ZZ; Robichaud AJ; Doller D
J Med Chem; 2011 Jul; 54(14):5070-81. PubMed ID: 21688779
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]