98 related articles for article (PubMed ID: 17931867)
1. Synthesis and in-vitro biological activity of macrocyclic urea Chk1 inhibitors.
Li G; Tao ZF; Tong Y; Przytulinska MK; Kovar P; Merta P; Chen Z; Zhang H; Sowin T; Rosenberg SH; Lin NH
Bioorg Med Chem Lett; 2007 Dec; 17(23):6499-504. PubMed ID: 17931867
[TBL] [Abstract][Full Text] [Related]
2. Structure-based design, synthesis, and biological evaluation of potent and selective macrocyclic checkpoint kinase 1 inhibitors.
Tao ZF; Wang L; Stewart KD; Chen Z; Gu W; Bui MH; Merta P; Zhang H; Kovar P; Johnson E; Park C; Judge R; Rosenberg S; Sowin T; Lin NH
J Med Chem; 2007 Apr; 50(7):1514-27. PubMed ID: 17352464
[TBL] [Abstract][Full Text] [Related]
3. Macrocyclic ureas as potent and selective Chk1 inhibitors: an improved synthesis, kinome profiling, structure-activity relationships, and preliminary pharmacokinetics.
Tao ZF; Chen Z; Bui MH; Kovar P; Johnson E; Bouska J; Zhang H; Rosenberg S; Sowin T; Lin NH
Bioorg Med Chem Lett; 2007 Dec; 17(23):6593-601. PubMed ID: 17935989
[TBL] [Abstract][Full Text] [Related]
4. Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors.
Li G; Hasvold LA; Tao ZF; Wang GT; Gwaltney SL; Patel J; Kovar P; Credo RB; Chen Z; Zhang H; Park C; Sham HL; Sowin T; Rosenberg SH; Lin NH
Bioorg Med Chem Lett; 2006 Apr; 16(8):2293-8. PubMed ID: 16446090
[TBL] [Abstract][Full Text] [Related]
5. 1-(5-Chloro-2-alkoxyphenyl)-3-(5-cyanopyrazin-2-yl)ureas [correction of cyanopyrazi] as potent and selective inhibitors of Chk1 kinase: synthesis, preliminary SAR, and biological activities.
Wang GT; Li G; Mantei RA; Chen Z; Kovar P; Gu W; Xiao Z; Zhang H; Sham HL; Sowin T; Rosenberg SH; Lin NH
J Med Chem; 2005 May; 48(9):3118-21. PubMed ID: 15857116
[TBL] [Abstract][Full Text] [Related]
6. Design, synthesis, and biological activity of 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one-based potent and selective Chk-1 inhibitors.
Wang L; Sullivan GM; Hexamer LA; Hasvold LA; Thalji R; Przytulinska M; Tao ZF; Li G; Chen Z; Xiao Z; Gu WZ; Xue J; Bui MH; Merta P; Kovar P; Bouska JJ; Zhang H; Park C; Stewart KD; Sham HL; Sowin TJ; Rosenberg SH; Lin NH
J Med Chem; 2007 Aug; 50(17):4162-76. PubMed ID: 17658776
[TBL] [Abstract][Full Text] [Related]
7. Synthesis and biological activities of new checkpoint kinase 1 inhibitors structurally related to granulatimide.
Conchon E; Anizon F; Aboab B; Prudhomme M
J Med Chem; 2007 Sep; 50(19):4669-80. PubMed ID: 17722905
[TBL] [Abstract][Full Text] [Related]
8. Design, synthesis and biological evaluation of thienopyridinones as Chk1 inhibitors.
Song P; Peng P; Han M; Cao X; Ma X; Liu T; Zhou Y; Hu Y
Bioorg Med Chem; 2014 Sep; 22(17):4882-92. PubMed ID: 25042558
[TBL] [Abstract][Full Text] [Related]
9. Synthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases.
Smaill JB; Lee HH; Palmer BD; Thompson AM; Squire CJ; Baker EN; Booth RJ; Kraker A; Hook K; Denny WA
Bioorg Med Chem Lett; 2008 Feb; 18(3):929-33. PubMed ID: 18191399
[TBL] [Abstract][Full Text] [Related]
10. Design, synthesis and SAR of thienopyridines as potent CHK1 inhibitors.
Zhao L; Zhang Y; Dai C; Guzi T; Wiswell D; Seghezzi W; Parry D; Fischmann T; Siddiqui MA
Bioorg Med Chem Lett; 2010 Dec; 20(24):7216-21. PubMed ID: 21074424
[TBL] [Abstract][Full Text] [Related]
11. Identification of novel aminothiazole and aminothiadiazole conjugated cyanopyridines as selective CHK1 inhibitors.
Gomha SM; Abdulla MM; Abou-Seri SM
Eur J Med Chem; 2015 Mar; 92():459-70. PubMed ID: 25594740
[TBL] [Abstract][Full Text] [Related]
12. Discovery of checkpoint kinase inhibitor (S)-5-(3-fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by structure-based design and optimization of thiophenecarboxamide ureas.
Oza V; Ashwell S; Almeida L; Brassil P; Breed J; Deng C; Gero T; Grondine M; Horn C; Ioannidis S; Liu D; Lyne P; Newcombe N; Pass M; Read J; Ready S; Rowsell S; Su M; Toader D; Vasbinder M; Yu D; Yu Y; Xue Y; Zabludoff S; Janetka J
J Med Chem; 2012 Jun; 55(11):5130-42. PubMed ID: 22551018
[TBL] [Abstract][Full Text] [Related]
13. Synthesis of selenophene derivatives as novel CHK1 inhibitors.
Hong PC; Chen LJ; Lai TY; Yang HY; Chiang SJ; Lu YY; Tsai PK; Hsu HY; Wei WY; Liao CB
Bioorg Med Chem Lett; 2010 Sep; 20(17):5065-8. PubMed ID: 20674356
[TBL] [Abstract][Full Text] [Related]
14. Synthesis and biological evaluation of 4'-(6,7-disubstituted-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-biphenyl-4-ol as potent Chk1 inhibitors.
Tao ZF; Li G; Tong Y; Chen Z; Merta P; Kovar P; Zhang H; Rosenberg SH; Sham HL; Sowin TJ; Lin NH
Bioorg Med Chem Lett; 2007 Aug; 17(15):4308-15. PubMed ID: 17544271
[TBL] [Abstract][Full Text] [Related]
15. Bis-imide granulatimide analogues as potent Checkpoint 1 kinase inhibitors.
Hénon H; Messaoudi S; Anizon F; Aboab B; Kucharczyk N; Léonce S; Golsteyn RM; Pfeiffer B; Prudhomme M
Eur J Pharmacol; 2007 Jan; 554(2-3):106-12. PubMed ID: 17134696
[TBL] [Abstract][Full Text] [Related]
16. Hsp90-inhibitor geldanamycin abrogates G2 arrest in p53-negative leukemia cell lines through the depletion of Chk1.
Sugimoto K; Sasaki M; Isobe Y; Tsutsui M; Suto H; Ando J; Tamayose K; Ando M; Oshimi K
Oncogene; 2008 May; 27(22):3091-101. PubMed ID: 18071310
[TBL] [Abstract][Full Text] [Related]
17. Macrocyclic compounds as anti-cancer agents: design and synthesis of multi-acting inhibitors against HDAC, FLT3 and JAK2.
Ning CQ; Lu C; Hu L; Bi YJ; Yao L; He YJ; Liu LF; Liu XY; Yu NF
Eur J Med Chem; 2015 May; 95():104-15. PubMed ID: 25800646
[TBL] [Abstract][Full Text] [Related]
18. Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors.
Janetka JW; Almeida L; Ashwell S; Brassil PJ; Daly K; Deng C; Gero T; Glynn RE; Horn CL; Ioannidis S; Lyne P; Newcombe NJ; Oza VB; Pass M; Springer SK; Su M; Toader D; Vasbinder MM; Yu D; Yu Y; Zabludoff SD
Bioorg Med Chem Lett; 2008 Jul; 18(14):4242-8. PubMed ID: 18547806
[TBL] [Abstract][Full Text] [Related]
19. Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors.
Oza V; Ashwell S; Brassil P; Breed J; Ezhuthachan J; Deng C; Grondine M; Horn C; Liu D; Lyne P; Newcombe N; Pass M; Read J; Su M; Toader D; Yu D; Yu Y; Zabludoff S
Bioorg Med Chem Lett; 2012 Mar; 22(6):2330-7. PubMed ID: 22342147
[TBL] [Abstract][Full Text] [Related]
20. Cyclosquaramides as kinase inhibitors with anticancer activity.
Villalonga P; Fernández de Mattos S; Ramis G; Obrador-Hevia A; Sampedro A; Rotger C; Costa A
ChemMedChem; 2012 Aug; 7(8):1472-80. PubMed ID: 22777958
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]