These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
92 related articles for article (PubMed ID: 17931867)
1. Synthesis and in-vitro biological activity of macrocyclic urea Chk1 inhibitors. Li G; Tao ZF; Tong Y; Przytulinska MK; Kovar P; Merta P; Chen Z; Zhang H; Sowin T; Rosenberg SH; Lin NH Bioorg Med Chem Lett; 2007 Dec; 17(23):6499-504. PubMed ID: 17931867 [TBL] [Abstract][Full Text] [Related]
2. Structure-based design, synthesis, and biological evaluation of potent and selective macrocyclic checkpoint kinase 1 inhibitors. Tao ZF; Wang L; Stewart KD; Chen Z; Gu W; Bui MH; Merta P; Zhang H; Kovar P; Johnson E; Park C; Judge R; Rosenberg S; Sowin T; Lin NH J Med Chem; 2007 Apr; 50(7):1514-27. PubMed ID: 17352464 [TBL] [Abstract][Full Text] [Related]
3. Macrocyclic ureas as potent and selective Chk1 inhibitors: an improved synthesis, kinome profiling, structure-activity relationships, and preliminary pharmacokinetics. Tao ZF; Chen Z; Bui MH; Kovar P; Johnson E; Bouska J; Zhang H; Rosenberg S; Sowin T; Lin NH Bioorg Med Chem Lett; 2007 Dec; 17(23):6593-601. PubMed ID: 17935989 [TBL] [Abstract][Full Text] [Related]
4. Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors. Li G; Hasvold LA; Tao ZF; Wang GT; Gwaltney SL; Patel J; Kovar P; Credo RB; Chen Z; Zhang H; Park C; Sham HL; Sowin T; Rosenberg SH; Lin NH Bioorg Med Chem Lett; 2006 Apr; 16(8):2293-8. PubMed ID: 16446090 [TBL] [Abstract][Full Text] [Related]
5. 1-(5-Chloro-2-alkoxyphenyl)-3-(5-cyanopyrazin-2-yl)ureas [correction of cyanopyrazi] as potent and selective inhibitors of Chk1 kinase: synthesis, preliminary SAR, and biological activities. Wang GT; Li G; Mantei RA; Chen Z; Kovar P; Gu W; Xiao Z; Zhang H; Sham HL; Sowin T; Rosenberg SH; Lin NH J Med Chem; 2005 May; 48(9):3118-21. PubMed ID: 15857116 [TBL] [Abstract][Full Text] [Related]
6. Design, synthesis, and biological activity of 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one-based potent and selective Chk-1 inhibitors. Wang L; Sullivan GM; Hexamer LA; Hasvold LA; Thalji R; Przytulinska M; Tao ZF; Li G; Chen Z; Xiao Z; Gu WZ; Xue J; Bui MH; Merta P; Kovar P; Bouska JJ; Zhang H; Park C; Stewart KD; Sham HL; Sowin TJ; Rosenberg SH; Lin NH J Med Chem; 2007 Aug; 50(17):4162-76. PubMed ID: 17658776 [TBL] [Abstract][Full Text] [Related]
7. Synthesis and biological activities of new checkpoint kinase 1 inhibitors structurally related to granulatimide. Conchon E; Anizon F; Aboab B; Prudhomme M J Med Chem; 2007 Sep; 50(19):4669-80. PubMed ID: 17722905 [TBL] [Abstract][Full Text] [Related]
8. Design, synthesis and biological evaluation of thienopyridinones as Chk1 inhibitors. Song P; Peng P; Han M; Cao X; Ma X; Liu T; Zhou Y; Hu Y Bioorg Med Chem; 2014 Sep; 22(17):4882-92. PubMed ID: 25042558 [TBL] [Abstract][Full Text] [Related]
9. Synthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases. Smaill JB; Lee HH; Palmer BD; Thompson AM; Squire CJ; Baker EN; Booth RJ; Kraker A; Hook K; Denny WA Bioorg Med Chem Lett; 2008 Feb; 18(3):929-33. PubMed ID: 18191399 [TBL] [Abstract][Full Text] [Related]
10. Design, synthesis and SAR of thienopyridines as potent CHK1 inhibitors. Zhao L; Zhang Y; Dai C; Guzi T; Wiswell D; Seghezzi W; Parry D; Fischmann T; Siddiqui MA Bioorg Med Chem Lett; 2010 Dec; 20(24):7216-21. PubMed ID: 21074424 [TBL] [Abstract][Full Text] [Related]
11. Identification of novel aminothiazole and aminothiadiazole conjugated cyanopyridines as selective CHK1 inhibitors. Gomha SM; Abdulla MM; Abou-Seri SM Eur J Med Chem; 2015 Mar; 92():459-70. PubMed ID: 25594740 [TBL] [Abstract][Full Text] [Related]
12. Discovery of checkpoint kinase inhibitor (S)-5-(3-fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by structure-based design and optimization of thiophenecarboxamide ureas. Oza V; Ashwell S; Almeida L; Brassil P; Breed J; Deng C; Gero T; Grondine M; Horn C; Ioannidis S; Liu D; Lyne P; Newcombe N; Pass M; Read J; Ready S; Rowsell S; Su M; Toader D; Vasbinder M; Yu D; Yu Y; Xue Y; Zabludoff S; Janetka J J Med Chem; 2012 Jun; 55(11):5130-42. PubMed ID: 22551018 [TBL] [Abstract][Full Text] [Related]
13. Synthesis of selenophene derivatives as novel CHK1 inhibitors. Hong PC; Chen LJ; Lai TY; Yang HY; Chiang SJ; Lu YY; Tsai PK; Hsu HY; Wei WY; Liao CB Bioorg Med Chem Lett; 2010 Sep; 20(17):5065-8. PubMed ID: 20674356 [TBL] [Abstract][Full Text] [Related]
14. Synthesis and biological evaluation of 4'-(6,7-disubstituted-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-biphenyl-4-ol as potent Chk1 inhibitors. Tao ZF; Li G; Tong Y; Chen Z; Merta P; Kovar P; Zhang H; Rosenberg SH; Sham HL; Sowin TJ; Lin NH Bioorg Med Chem Lett; 2007 Aug; 17(15):4308-15. PubMed ID: 17544271 [TBL] [Abstract][Full Text] [Related]
16. Hsp90-inhibitor geldanamycin abrogates G2 arrest in p53-negative leukemia cell lines through the depletion of Chk1. Sugimoto K; Sasaki M; Isobe Y; Tsutsui M; Suto H; Ando J; Tamayose K; Ando M; Oshimi K Oncogene; 2008 May; 27(22):3091-101. PubMed ID: 18071310 [TBL] [Abstract][Full Text] [Related]
17. Macrocyclic compounds as anti-cancer agents: design and synthesis of multi-acting inhibitors against HDAC, FLT3 and JAK2. Ning CQ; Lu C; Hu L; Bi YJ; Yao L; He YJ; Liu LF; Liu XY; Yu NF Eur J Med Chem; 2015 May; 95():104-15. PubMed ID: 25800646 [TBL] [Abstract][Full Text] [Related]
18. Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors. Janetka JW; Almeida L; Ashwell S; Brassil PJ; Daly K; Deng C; Gero T; Glynn RE; Horn CL; Ioannidis S; Lyne P; Newcombe NJ; Oza VB; Pass M; Springer SK; Su M; Toader D; Vasbinder MM; Yu D; Yu Y; Zabludoff SD Bioorg Med Chem Lett; 2008 Jul; 18(14):4242-8. PubMed ID: 18547806 [TBL] [Abstract][Full Text] [Related]
19. Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors. Oza V; Ashwell S; Brassil P; Breed J; Ezhuthachan J; Deng C; Grondine M; Horn C; Liu D; Lyne P; Newcombe N; Pass M; Read J; Su M; Toader D; Yu D; Yu Y; Zabludoff S Bioorg Med Chem Lett; 2012 Mar; 22(6):2330-7. PubMed ID: 22342147 [TBL] [Abstract][Full Text] [Related]
20. Cyclosquaramides as kinase inhibitors with anticancer activity. Villalonga P; Fernández de Mattos S; Ramis G; Obrador-Hevia A; Sampedro A; Rotger C; Costa A ChemMedChem; 2012 Aug; 7(8):1472-80. PubMed ID: 22777958 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]