BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

136 related articles for article (PubMed ID: 17933533)

  • 1. Hit generation and exploration: imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases.
    Bavetsias V; Sun C; Bouloc N; Reynisson J; Workman P; Linardopoulos S; McDonald E
    Bioorg Med Chem Lett; 2007 Dec; 17(23):6567-71. PubMed ID: 17933533
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Optimization of imidazo[4,5-b]pyridine-based kinase inhibitors: identification of a dual FLT3/Aurora kinase inhibitor as an orally bioavailable preclinical development candidate for the treatment of acute myeloid leukemia.
    Bavetsias V; Crumpler S; Sun C; Avery S; Atrash B; Faisal A; Moore AS; Kosmopoulou M; Brown N; Sheldrake PW; Bush K; Henley A; Box G; Valenti M; de Haven Brandon A; Raynaud FI; Workman P; Eccles SA; Bayliss R; Linardopoulos S; Blagg J
    J Med Chem; 2012 Oct; 55(20):8721-34. PubMed ID: 23043539
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate.
    Bavetsias V; Large JM; Sun C; Bouloc N; Kosmopoulou M; Matteucci M; Wilsher NE; Martins V; Reynisson J; Atrash B; Faisal A; Urban F; Valenti M; de Haven Brandon A; Box G; Raynaud FI; Workman P; Eccles SA; Bayliss R; Blagg J; Linardopoulos S; McDonald E
    J Med Chem; 2010 Jul; 53(14):5213-28. PubMed ID: 20565112
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The aurora kinase inhibitor CCT137690 downregulates MYCN and sensitizes MYCN-amplified neuroblastoma in vivo.
    Faisal A; Vaughan L; Bavetsias V; Sun C; Atrash B; Avery S; Jamin Y; Robinson SP; Workman P; Blagg J; Raynaud FI; Eccles SA; Chesler L; Linardopoulos S
    Mol Cancer Ther; 2011 Nov; 10(11):2115-23. PubMed ID: 21885865
    [TBL] [Abstract][Full Text] [Related]  

  • 5. 7-(Pyrazol-4-yl)-3H-imidazo[4,5-b]pyridine-based derivatives for kinase inhibition: Co-crystallisation studies with Aurora-A reveal distinct differences in the orientation of the pyrazole N1-substituent.
    Bavetsias V; Pérez-Fuertes Y; McIntyre PJ; Atrash B; Kosmopoulou M; O'Fee L; Burke R; Sun C; Faisal A; Bush K; Avery S; Henley A; Raynaud FI; Linardopoulos S; Bayliss R; Blagg J
    Bioorg Med Chem Lett; 2015 Oct; 25(19):4203-9. PubMed ID: 26296477
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells.
    Bouloc N; Large JM; Kosmopoulou M; Sun C; Faisal A; Matteucci M; Reynisson J; Brown N; Atrash B; Blagg J; McDonald E; Linardopoulos S; Bayliss R; Bavetsias V
    Bioorg Med Chem Lett; 2010 Oct; 20(20):5988-93. PubMed ID: 20833547
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design, synthesis and biological evaluation of novel 3H-imidazole [4,5-b] pyridine derivatives as selective mTOR inhibitors.
    Zhang L; Bu T; Bao X; Liang T; Ge Y; Xu Y; Zhu Q
    Bioorg Med Chem Lett; 2017 Aug; 27(15):3395-3398. PubMed ID: 28633896
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design, synthesis and bioevaluation of dihydropyrazolo[3,4-b]pyridine and benzo[4,5]imidazo[1,2-a]pyrimidine compounds as dual KSP and Aurora-A kinase inhibitors for anti-cancer agents.
    Fu RG; You QD; Yang L; Wu WT; Jiang C; Xu XL
    Bioorg Med Chem; 2010 Nov; 18(22):8035-43. PubMed ID: 20934346
    [TBL] [Abstract][Full Text] [Related]  

  • 9. 3-Cyano-6-(5-methyl-3-pyrazoloamino)pyridines: selective Aurora A kinase inhibitors.
    Ando R; Ikegami H; Sakiyama M; Ooike S; Hayashi M; Fujino Y; Abe D; Nakamura H; Mishina T; Kato H; Iwase Y; Tomozane H; Morioka M
    Bioorg Med Chem Lett; 2010 Aug; 20(15):4709-11. PubMed ID: 20573509
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Design and synthesis of 3-(4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridin-2-yl)-1H-quinolin-2-ones as VEGFR-2 kinase inhibitors.
    Han SY; Choi JW; Yang J; Chae CH; Lee J; Jung H; Lee K; Ha JD; Kim HR; Cho SY
    Bioorg Med Chem Lett; 2012 Apr; 22(8):2837-42. PubMed ID: 22450128
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Bioisosteric approach to the discovery of imidazo[1,2-a]pyrazines as potent Aurora kinase inhibitors.
    Meng Z; Kulkarni BA; Kerekes AD; Mandal AK; Esposite SJ; Belanger DB; Reddy PA; Basso AD; Tevar S; Gray K; Jones J; Smith EB; Doll RJ; Siddiqui MA
    Bioorg Med Chem Lett; 2011 Jan; 21(1):592-8. PubMed ID: 21075632
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Aurora isoform selectivity: design and synthesis of imidazo[4,5-b]pyridine derivatives as highly selective inhibitors of Aurora-A kinase in cells.
    Bavetsias V; Faisal A; Crumpler S; Brown N; Kosmopoulou M; Joshi A; Atrash B; Pérez-Fuertes Y; Schmitt JA; Boxall KJ; Burke R; Sun C; Avery S; Bush K; Henley A; Raynaud FI; Workman P; Bayliss R; Linardopoulos S; Blagg J
    J Med Chem; 2013 Nov; 56(22):9122-35. PubMed ID: 24195668
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors.
    Wang S; Midgley CA; Scaërou F; Grabarek JB; Griffiths G; Jackson W; Kontopidis G; McClue SJ; McInnes C; Meades C; Mezna M; Plater A; Stuart I; Thomas MP; Wood G; Clarke RG; Blake DG; Zheleva DI; Lane DP; Jackson RC; Glover DM; Fischer PM
    J Med Chem; 2010 Jun; 53(11):4367-78. PubMed ID: 20462263
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Design, synthesis, and molecular docking study of 3H-imidazole[4,5-c]pyridine derivatives as CDK2 inhibitors.
    Wu YZ; Ying HZ; Xu L; Cheng G; Chen J; Hu YZ; Liu T; Dong XW
    Arch Pharm (Weinheim); 2018 Jun; 351(6):e1700381. PubMed ID: 29708285
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Design, Synthesis, and Biological Evaluation of Imidazo[1,2-
    Yu Y; Han Y; Zhang F; Gao Z; Zhu T; Dong S; Ma M
    J Med Chem; 2020 Mar; 63(6):3028-3046. PubMed ID: 32069401
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis and biological evaluation of 5-(fluoro-substituted-6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)imidazoles as inhibitors of transforming growth factor-β type I receptor kinase.
    Krishnaiah M; Jin CH; Sheen YY; Kim DK
    Bioorg Med Chem Lett; 2015 Nov; 25(22):5228-31. PubMed ID: 26483198
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Reversine, a novel Aurora kinases inhibitor, inhibits colony formation of human acute myeloid leukemia cells.
    D'Alise AM; Amabile G; Iovino M; Di Giorgio FP; Bartiromo M; Sessa F; Villa F; Musacchio A; Cortese R
    Mol Cancer Ther; 2008 May; 7(5):1140-9. PubMed ID: 18483302
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Design, synthesis and structure--activity relationship (SAR) studies of imidazo[4,5-b]pyridine derived purine isosteres and their potential as cytotoxic agents.
    Sajith AM; Abdul Khader KK; Joshi N; Reddy MN; Syed Ali Padusha M; Nagaswarupa HP; Nibin Joy M; Bodke YD; Karuvalam RP; Banerjee R; Muralidharan A; Rajendra P
    Eur J Med Chem; 2015 Jan; 89():21-31. PubMed ID: 25462222
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Design, synthesis, biological activity evaluation of 3-(4-phenyl-1H-imidazol-2-yl)-1H-pyrazole derivatives as potent JAK 2/3 and aurora A/B kinases multi-targeted inhibitors.
    Zheng YG; Wang JA; Meng L; Pei X; Zhang L; An L; Li CL; Miao YL
    Eur J Med Chem; 2021 Jan; 209():112934. PubMed ID: 33109396
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Cell division cycle 7 kinase inhibitors: 1H-pyrrolo[2,3-b]pyridines, synthesis and structure-activity relationships.
    Ermoli A; Bargiotti A; Brasca MG; Ciavolella A; Colombo N; Fachin G; Isacchi A; Menichincheri M; Molinari A; Montagnoli A; Pillan A; Rainoldi S; Sirtori FR; Sola F; Thieffine S; Tibolla M; Valsasina B; Volpi D; Santocanale C; Vanotti E
    J Med Chem; 2009 Jul; 52(14):4380-90. PubMed ID: 19555113
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.